Clinical characteristics of patients with ROS1 gene rearrangement in non-small cell lung cancer: a meta-analysis

Abstract

Background ROS1 gene rearrangement has been reported in several types of cancers, including non-small cell lung cancer (NSCLC). It is reported that tyrosine kinase inhibitors are effective in the treatment of ROS1- rearranged NSCLC. Therefore, the identification of ROS1 rearrangement can be used as potential therapeutic target in lung cancer. Epidemiological data indicates that ROS1 gene rearrangement occurs in approximately 1–2% of NSCLC patients. The small sample sizes of the existing associated studies only represent the characteristics of patients in specific regions or countries, and there is still no latest statistical analysis on ROS1 gene rearrangement anywhere in the world. Methods We conducted a systematic search of the PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), CBM, CNKI, Wanfang, and VIP databases to identify studies on ROS1 gene rearrangement in NSCLC patients from January 1, 2015 to October 27, 2019. We conducted a meta-analysis to investigate the relationship between ROS1 gene rearrangement and clinical characteristics of NSCLC patients. The four clinical features are as follows: gender, smoking status, pathological type, and lung cancer stage. Results Thirty-nine studies constituting of 25,055 NSCLC patients were eligible for inclusion in this meta-analysis. A prominently higher rate of ROS1 gene rearrangement was observed in female NSCLC patients (OR =1.94, 95% CI: 1.62–2.32%, P<0.05), patients with no smoking history (OR =2.82, 95% CI: 2.24–3.55%, P<0.05), patients with adenocarcinoma (OR =1.55, 95% CI: 1.14–2.11%, P<0.05), and patients with stage III–IV disease (OR =1.50, 95% CI: 1.15–1.94%, P<0.05). Our meta-analysis also showed that the prevalence of ROS1 rearrangement in adenocarcinoma was 2.49% (95% CI: 1.92–3.11%), while it was lower in non-adenocarcinoma patients (1.37%). Conclusions ROS1 gene rearrangement was more predominant in female patients, patients without smoking history, patients with adenocarcinoma and patients with advanced-stage disease (stages III to IV).

Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations

“…The clinical characteristics of ROS1 - and ALK -rearranged NSCLCs are quite similar: Both rearrangements are more common in younger, never- or light-smoker patients with a histologic diagnosis of adenocarcinoma [ 36 ]. Moreover, ROS1 rearrangements are more common in women [ 37 ]. ROS1 translocations have been associated with the presence of lepidic patterns or extracellular mucin [ 38 ].…”

“…ROS1 translocations have been associated with the presence of lepidic patterns or extracellular mucin [ 38 ]. Disease is commonly diagnosed at an advanced (III or IV) stage [ 37 ]. The central nervous system (CNS) is frequently involved in stage IV disease, or CNS may represent the first site of progression on crizotinib given its limited capability to penetrate the blood–brain barrier [ 39 ].…”