Clinical characteristics of patients with epilepsy in a specialist neuropsychiatry service

Osman, Adam; Seri, Stefano; Cavanna, Andrea E.

doi:10.1016/j.yebeh.2016.02.033

Cited by 19 publications

(12 citation statements)

References 37 publications

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“…These clinical characteristics were recently confirmed in a study of a specialist neuropsychiatry service for PWE, where 27% suffered from generalized anxiety 11 . AnxD, as other psychiatric comorbidities, are however often under recognized and undertreated in PwE 6 , but can significantly affect QoL.…”

Section: Introductionmentioning

confidence: 73%

“…The HADS was originally designed as a screening tool for depression and anxiety in hospital outpatient clinics 16 normal (0-7), mild (8-10), moderate (11)(12)(13)(14), severe (15)(16)(17)(18)(19)(20)(21). Scores for the entire scale (emotional distress) range from 0-42, with higher scores indicating more distress.…”

Section: Hospital Anxiety and Depression Scale (Hads)mentioning

confidence: 99%

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Screening of anxiety and quality of life in people with epilepsy

Özmen

Leibetseder

Cock

et al. 2017

Seizure

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PURPOSEUp to 60% of people with epilepsy (PwE) have psychiatric comorbidity including anxiety.Anxiety remains under recognized in PwE. This study investigates if screening tools validated for depression could be used to detect anxiety disorders in PWE. Additionally it analyses the effect of anxiety on QoL. METHODS261 participants with a confirmed diagnosis of epilepsy were included. Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Emotional Thermometers (ET), both validated to screen for depression were used. Hospital Anxiety and Depression ScaleAnxiety (HADS-A) with a cut off for moderate and severe anxiety was used as the reference standard. QoL was measured with EQ5-D. Sensitivity, specificity, positive and negative predictive value and ROC analysis as well as multivariate regression analysis were performed. RESULTSPatients with depression (n=46) were excluded as multivariate regression analysis showed that depression was the only significant determinant of having anxiety in the group. Against HADS-A, NDDI-E and ET-7 showed highest level of accuracy in recognizing anxiety with ET7 being the most effective tool. QoL was significantly reduced in PwE and anxiety. CONCLUSIONSOur study showed that reliable screening for moderate to severe anxiety in PwE without comorbid depression is feasible with screening tools for depression. The cut off values for anxiety are different from those for depression in ET7 but very similar in NDDI-E. ET7 can be applied to screen simultaneously for depression and "pure" anxiety. Anxiety reduces significantly QoL. We recommend screening as an initial first step to rule out patients who are unlikely to have anxiety.Highlights  Moderate to severe anxiety is a frequent comorbidity in epilepsy, in our cohort prevalence was 26,4%  Depression was the only significant determinant for anxiety, prevalence of anxiety in non-depressed PwE was 15,8%. Screening for anxiety independent from depression can be achieved with the ET7 tool.

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Section: Introductionmentioning

confidence: 73%

Section: Hospital Anxiety and Depression Scale (Hads)mentioning

confidence: 99%

Screening of anxiety and quality of life in people with epilepsy

Özmen

Leibetseder

Cock

et al. 2017

Seizure

View full text Add to dashboard Cite

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“…The association between depression and injuries is another interesting finding of our study. Depression represents one of the most commonly reported psychiatric comorbidities of epilepsy , being reported in up to one third of patients . Patients with psychiatric comorbidities are also more likely to be drug refractory and it is possible that the association with injuries reflects the increased chances of having uncontrolled seizures.…”

Section: Discussionmentioning

confidence: 99%

The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy

Özmen

Mula

Agrawal

et al. 2017

Euro J of Neurology

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“…Providers cannot support and monitor treatment adherence, mood, or enhance their patients’ healthful behaviors, coping skills, and quality of life on a daily basis. Providers may also fail to recognize or treat common co-morbidities such as depression, anxiety, cognitive impairment, and sleep disorders that can adversely affect seizure control and quality of life [3–4]. Often lacking a multidisciplinary team, or having insufficient time in clinical encounters, providers cannot fully address these and related psychosocial needs of their patients with epilepsy [5].…”

Section: Why Would Clinicians Want Patients To Manage Themselves?mentioning

confidence: 99%