Clinical characteristics of patients with neurogenic bladder due to myelomeningocele – Eighteen-year retrospective study; University Children's Hospital, Bialystok, Poland

Korzeniecka‐Kozerska, Agata; Kulesza-Brończyk, Bożena; Okurowska-Zawada, Bożena; Lewandowska-Kidoń, Teresa

doi:10.1016/j.pepo.2015.05.002

Cited by 3 publications

(13 citation statements)

References 21 publications

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“…Mean follow‐up ranged from 0.5 to 11 years . In this young population, 951 (61%) were receiving treatment for their NLUTD at the time of the inclusion in 16/28 studies . Of those, 635 (67%) were managed by intermittent catheterization (IC) (see Table ).…”

Section: Resultsmentioning

confidence: 99%

“…A reduction of compliance was found in 568 (46.3%) spina bifida patients by 12/16 reports. The mean compliance in children ranged from 5.8 to 25.6 mL/cmH 2 O in 4/16 studies . Poor compliance cut‐off adopted by authors varied from <9 and <20 mL/cmH 2 O …”

Section: Resultsmentioning

confidence: 99%

“…Five hundred and twenty‐nine (36.1%) young patients were diagnosed with DSD by 16/28 authors. Only two authors reported the mean post‐void residual volume (PVR) ranging from 47 to 183 mL …”

Section: Resultsmentioning

confidence: 99%

“…Considering the evaluation of kidney function using laboratory tests, only two studies reported a serum creatinine >1 mg/dL (88.42 μmol/L) in three and two young patients, respectively . Two other authors reported the mean level of GFR ranging from 67.5 to 161.25 mL/min …”

Section: Resultsmentioning

confidence: 99%

“…36,44 In this young population, 951 (61%) were receiving treatment for their NLUTD at the time of the inclusion in 16/28 studies. 17,18,22,23,26,31,33,35,36,38,40,49,51,[54][55][56] Of those, 635 (67%) were managed by intermittent catheterization (IC) (see Table 1). In 21/49 studies, adults affected by the following neurological diseases were included: traumatic SCI (n = 1210, 59.2%), multiple sclerosis (MS) (n = 706, 34.5%), spina bifida (n = 112, 5.5%).…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

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Value of urodynamic findings in predicting upper urinary tract damage in neuro‐urological patients: A systematic review

Musco

Padilla‐Fernández

Popolo

et al. 2018

Neurourology and Urodynamics

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Patients with SB and SCI have a higher risk of developing UUTD (mainly reported as HDN) compared to those with MS. Reduced compliance and high DLPP were major risk factors for UUTD. Although our findings clarify the mandatory role of urodynamics in the management of NLUTD, standardization and better implementation of assessments in daily practice may further improve outcomes of neuro-urological patients based on objective measurements, that is, urodynamics.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study and Patient Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Value of urodynamic findings in predicting upper urinary tract damage in neuro‐urological patients: A systematic review

Musco

Padilla‐Fernández

Popolo

et al. 2018

Neurourology and Urodynamics

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Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele?

Miklaszewska

Korohoda

Zachwieja

et al. 2016

IJERPH

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Myelomeningocele (MMC) results from a failure of normal neural tube fusion in early fetal development. Retrospective, observational study of medical data of 54 children treated in Pediatric Nephrology and Urology Clinics for five years was performed. The following data were analyzed: serum creatinine, eGFR, urine analysis, renal scintigraphy (RS), renal ultrasound, and urodynamics. Mean age of studied population: 12.3 years, median of eGFR at the beginning and at the end of survey was 110.25 and 116.5 mL/min/1.73 m2 accordingly. Median of frequency of urinary tract infections (fUTI): 1.2 episodes/year. In 24 children: low-pressure, in 30 children: high-pressure bladder was noted. Vesicouretral reflux (VUR) was noted in 23 children (42.6%). fUTI were more common in high-grade VUR group. High-grade VURs were more common in group of patients with severe renal damage. At the end of the survey 11.1% children were qualified to higher stages of chronic kidney disease. Renal parenchyma damage progression in RS was noted in 22.2% children. Positive VUR history, febrile recurrent UTIs, bladder wall trabeculation, and older age of the patients constitute risk factors of abnormal renal scans. More than 2.0 febrile, symptomatic UTIs annually increase by 5.6-fold the risk of severe renal parenchyma damage after five years.

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A two-centre study of risk factors involved in renal deterioration in neurogenic bladder in children after myelomeningocele

Bagińska¹,

Miklaszewska²,

Liszewska³

et al. 2019

polp

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Introduction: Myelomeningocele (MMC) is the first cause of neurogenic bladder in children. Adequate nephrourological management is crucial to prevent renal damage and bladder dysfunction. In the last decade, the prognosis of MMC children has dramatically improved, but can we do better? We wanted to detect risk factors involved in renal deterioration in MMC patients. Material and methods: This retrospective analysis was based on 178 children with MMC (99 girls and 79 boys) from two Polish hospitals, in Bialystok and Cracow. The children's medical records were analysed to determine sex, age, and kidney and urinary tract ultrasound, voiding cystourethrogram, and urodynamic findings. The number of clean intermittent catheterisations performed per day, cystatin C, serum creatinine, urea, and glomerular filtration rate (GFR) Schwartz were also recorded. The Hoffer scale was used to assess MMC children's motor function. Results: Of the 111 from Bialystok and 67 children from Cracow, with a median age of nine years, 45 (25%) had vesicoureteral reflux. The most common urodynamic finding was overactive bladder with a prevalence of 59%. There were statistically significant differences between girls and boys, including the presence of reflux, increased echogenicity of the kidneys' parenchyma in ultrasound examination and cystometric capacity in urodynamic study. There were statistically significant differences between the Hoffer scale groups, including GFR Schwartz. The number of performed urodynamics correlated with GFR Schwartz, serum concentrations of cystatin C, and creatinine. Conclusions: Potential risk factors of renal deterioration in children with MMC are abnormalities in ultrasound, the presence of high-grade vesicoureteral reflux in cystogram, increased bladder pressure on urodynamics, hyperfiltration, and increased levels of cystatin C. Urodynamic evaluation may play a role in the management of children with MMC by identifying those with increased bladder pressures. Frequent urodynamic assessment may contribute to prevention of renal function in children with MMC.

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Clinical characteristics of patients with neurogenic bladder due to myelomeningocele – Eighteen-year retrospective study; University Children's Hospital, Bialystok, Poland

Cited by 3 publications

References 21 publications

Value of urodynamic findings in predicting upper urinary tract damage in neuro‐urological patients: A systematic review

Value of urodynamic findings in predicting upper urinary tract damage in neuro‐urological patients: A systematic review

Can We Further Improve the Quality of Nephro-Urological Care in Children with Myelomeningocele?

A two-centre study of risk factors involved in renal deterioration in neurogenic bladder in children after myelomeningocele

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