Clinical Characteristics of Patients Diagnosed with Synthetic Cannabinoid (Bonsai) Intoxication in Intensive Care Unit

Altınışık, Uğur; Altınışık, Hatice Betül; Şimşek, Tuncer; Doğu, Tüğba; Şimşek, Esen; Aydın, Halide

doi:10.4274/tybdd.36025

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…At low to moderate doses, cannabinoids induce tachycardia and increase cardiac output by a sympathomimetic effect whereas, at higher doses, they cause bradycardia and hypotension by their parasympathomimetic effect (23,24). Studies conducted so far have shown that affected patients most commonly experienced tachycardia and hypertension, while bradycardia and hypotension were less common (25)(26)(27)(28). We could not find any abnormal vital parameters except for tachypnea, and vital parameters were not correlated to intoxication status.…”

Section: Discussionmentioning

confidence: 99%

“…The authors attributed this result to the possibility of a variety of substances being admixed with synthetic cannabinoids, such as agricultural chemicals, fluorescent dust, Veronika and industrial chemicals (32). Altınışık et al (27) reported that four of 12 patients admitted to intensive care unit after using Bonsai had impaired hepatic and renal function, with renal function recovered in 48 hours but hepatic markers remained elevated for a longer period. It was reported that synthetic cannabinoid use was associated with acute tubular necrosis, resulting in acute renal failure (30,31,33).…”

Section: Discussionmentioning

confidence: 99%

“…While synthetic cannabinoids have not been consistently reported to cause respiratory difficulty and/or respiratory arrest (37), pulmonary fluid accumulation and respiratory depression due to long-term synthetic cannabinoid use have been reported (36,38). Altınışık et al (27) reported that one of 12 patients with loss of consciousness due to Bonsai use needed intubation. Küçük et al (7) reported that 3% required intubation.…”

Section: Discussionmentioning

confidence: 99%

“…Among patients who were admitted to the intensive care unit for intoxication, the intensive care follow-up period was reported to be three days (41,42). Altınışık et al (27) reported that most of the patients admitted to the intensive care unit after synthetic cannabinoid use regained consciousness by 24 hours and the remainders by 48 hours. They reported a follow-up period of three days and recommended a follow-up period of at least three days (27).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of the Clinical Course and Outcomes of Bonsai Use

Kavak¹,

Çavuş²,

Kavak³

et al. 2019

Eurasian J Emerg Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the Clinical Course and Outcomes of Bonsai Use

Kavak¹,

Çavuş²,

Kavak³

et al. 2019

Eurasian J Emerg Med

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“…Altınışık ve ark.nın çalışmasında; 2004-2005 yılları arasında, 16-41 yıl olan toplam 12 bonzai zehirlenme olgusu sunulmuş, bunların sadece bir tanesi mekanik ventilasyona ihtiyaç duymuştur. 24 Akut zehirlenmelerde mortalite oranı literatürde %0,03 ile %27 arasında değişmektedir. [25][26][27] Ülkemizde ise zehirlenmeye bağlı mortalite oranı %0,4 ile %5,6 arasında bildirilmiştir.…”

Section: Discussionunclassified

Evaluation of Acute Intoxication Cases Followed in Kayseri Training and Research Hospital Anesthesiology Intensive Care Unit

Destegül¹,

Çapar²

2018

Turkiye Klinikleri J Anest Reanim

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8ehirlenmeler tüm dünyada önemli bir sağlık sorunu olup, sık rastlanılan medikal acillerdendir.1 Gelişmekte olan ülkelerde zehirlenmeler %0,07-0,7 sıklığında görülmektedir.2 Ülkemizde de Sağlık Bakanlığının verilerine göre, 2002 yılında tüm hastaların %4,2'sinin zehirlenme vakası olduğu rapor edilmiştir. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Zehirlenme; ilaç zehirlenmesi; yoğun bakım ünitesi A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of the retrospective study was to analyze demographic and epidemiolgical features of intoxication cases in our city, Kayseri. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Patients, the number of 109 included to the study, who were followed up in the intensive care unit due to the acute intoxication in Kayseri Educational and Research Hospital between 2014-2016 years. Patient's age, gender, education level, type of toxic agent, hospitalization day, number of cases per month, and prognosis were examined. R Re es su ul lt ts s: : A total of 109 poisoned patients consist of 76 (70%) womenand 33 (30%) men and the rate is about 2.3/1. The most common cause of poisoning was releated to drug therapy and antidepressants were more frequent agents in drug group. The second most common cause was carbon monoxide and mushroom. A hundered and seven of them were discharged from hospital (98.16%), 1 of them was transported to another unit (0.91%) and 1 of them died (0.91%) during treatment period. C Co on nc cl lu us si io on n: : Young age and women are found to be the highest risk group for acute intoxication and medicaldrug poisoning was also found to be the most common type of intoxication.

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A 4-Year Retrospective Analysis of Patients Presenting at the Emergency Department With Synthetic Cannabinoid Intoxication in Turkey

Altıntop¹

2020

J Clin Psychopharmacol

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Purpose/Background The number of patients with acute synthetic cannabinoid intoxication (SCI) has increased in recent years although the prohibition of its legal sale and use in Turkey despite other countries allowing to some extent sale and use. The reported clinical findings of acute SCI are similar to the symptoms of several diseases. The first case of acute SCI seen in our hospital was in 2014. The aim of this study was to share the data of synthetic cannabinoid use in a research hospital in Turkey and to contribute the epidemiologic data globally betwen 2014 and 2017. Methods/Procedures A retrospective evaluation was made of patients who presented at emergency department (ED) because of SCI between January 2014 and December 2017. The initial diagnosis of the patients was done either via their self-report or clinician's clinical observation (family history with hallucination, lethargy, convulsions, dizziness, etc.). Totally, 352 patients were included to the study whose cannabioid use was proven with their urine drug analysis. Findings/Results Men were predominantly high (93.8%). Nearly all patients (93.5%) were followed up and discharged in 24 hours. Among them, 21 (5.9%) patients were admitted for hospitalization, and mortality was seen in 2 (0.6%). The mean number of previous presentations at ED with a similar diagnosis was 8.6 ± 10.31. Implications/Conclusions Great care must be taken in respect of complications related to SCI, which can even result in death. Patients have a tendency to not disclose the substance they have taken because it is illegal. Patients presenting at ED with recurrent symptoms must be referred to relevant legal authorities. For patients presenting with different clinical effects, SCI must be considered.

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Clinical Characteristics of Patients Diagnosed with Synthetic Cannabinoid (Bonsai) Intoxication in Intensive Care Unit

Cited by 8 publications

References 9 publications

Investigation of the Clinical Course and Outcomes of Bonsai Use

Investigation of the Clinical Course and Outcomes of Bonsai Use

Evaluation of Acute Intoxication Cases Followed in Kayseri Training and Research Hospital Anesthesiology Intensive Care Unit

A 4-Year Retrospective Analysis of Patients Presenting at the Emergency Department With Synthetic Cannabinoid Intoxication in Turkey

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