Clinical characteristics of oral mucosal lesions in patients with systemic lupus erythematosus and their association with clinical and laboratory parameters

Abstract

Introduction. Systemic lupus erythematosus (SLE) is an autoimmune disease that includes a broad spectrum of mucocutaneous manifestations. Objectives. To characterize the clinical spectrum of oral mucosal lesions in patients with SLE and to analize their association with clinical and laboratory parameters. Methods. We performed a cross-sectional study with systematic oral evaluations in SLE adult patients. Systemic and cutaneous lupus activities were recorded. We collected epidemiologic, clinical, and laboratory data. Statistical analysis included the kappa coefficient, X2 test, Fisher’s exact test and Mann-Whitney U-test, adjusting for multiple comparisons according to Bonferroni’s method. Results. A total of 181 patients (92.8% females) were included, with a median age of 37 (range 16-76) years. Cutaneous, systemic, and oral manifestations of lupus erythematosus (LE) activity were found in 31.5%, 23.8% and 18.8% of patients, respectively. Higher titres of anti-double-stranded (ds) DNA antibodies were detected in patients with LE-related oral lesions (LEOL) when compared to those without LEOL [356 (82-1083) UI vs 45 (0-417) UI; p=0.02). LEOL did not correlate to cutaneous (k=0.380) nor systemic (k=0.228) LE-activity (p<0.01). Conclusions. Oral manifestations related to SLE were significantly associated to anti double-ds DNA antibodies. LEOL were independent of cutaneous and systemic activity.

Clinical atrophy patterns of filiform papillae of the tongue and their relationship with the serum levels of iron, vitamin B12 and folic acid in patients with systemic diseases

“…In this study, this entity was more frequent in subjects with systemic lupus erythematosus. Recently, the prevalence of benign migratory glossitis in this population was reported to be 8%, 21 in contrast with the 36% reported in this study, this association was maintained even after adjusting for confusors. Nonetheless, the descriptions of benign migratory glossitis in subjects with systemic lupus erythematosus are vague, and its association with this disease is not clear 51 .…”

“…In our country, there is limited information regarding the frequency and clinical features of the FP atrophy among different systemic diseases 18–21 ; therefore, the objective of this work was to evaluate the presence and clinical patterns of FP atrophy and their relationship with some serum vitamins and minerals, in a third‐level care center with a focus on systemic diseases and nutrition.…”

“…In recent years, a research group showed in a sample of more than 1,000 Chinese subjects, the association among the presence of atrophic glossitis and low levels of vitamin B 12 , iron and folic acid, 14 hematinic deficiencies, 15 and hyperhomocysteinemia 16,17 ; while other authors have found an equivocal relationship between atrophic glossitis and protein calorie malnutrition. 4 In our country, there is limited information regarding the frequency and clinical features of the FP atrophy among different systemic diseases [18][19][20][21] ; therefore, the objective of this work was to evaluate the presence and clinical patterns of FP atrophy and their relationship with some serum vitamins and minerals, in a third-level care center with a focus on systemic diseases and nutrition.…”