Clinical Characteristics of Metastatic Tumors to the Ovaries

Abstract

Approximately 5-30% of the ovarian cancers are metastatic malignancies. The prevalence of metastatic ovarian tumors varies with the incidence rates and spread patterns of primary malignancies. We evaluated the prevalence, pre- and postoperative characteristics of metastatic ovarian cancer in Korean women. We reviewed the records for 821 ovarian malignancies with pathological consultation from 1996-2006 and recorded patient demographical, radiological, histopathological, and survival data. The study included 112 cases of histologically confirmed metastatic ovarian cancer. Metastatic ovarian cancer accounted for 13.6% of all ovarian malignancy, primarily arising from the gastrointestinal tract. The preoperative detection rate with imaging was 75%, and none of the radiological or serological features were useful for differential diagnosis. In multivariate analysis for prognostic variables, the only significant factor was the primary tumor site (p=0.004). Furthermore, extensive resection increased survival for some patients. The differential diagnosis of metastatic ovarian cancer can be problematic, so multiple diagnostic approaches are necessary. The extent of cytoreductive surgery for this type of tumor must be decided on a case-by-case basis.

Is a Surgical Approach Justified in Metachronous Krukenberg Tumor from Gastric Cancer? A Systematic Review

“…Six of the included articles reported age at presentation and percentage of pre/postmenopausal patients [7,26,27,31,34,36]. Most of the patients presented at a premenopausal age (range 44-48 years; percentage of premenopausal patients over the total: 59.1-76.5%).…”

“…There was no disagreement regarding eligibility of full-text articles (Cohen's kappa = 1). Finally, a total of 13 articles dated between 2002 and 2017 fulfilled the selection criteria and were therefore included in this systematic review [7,8,26,27,28,29,30,31,32,33,34,35,36]; this pool of articles consisted of 13 retrospective reports. Characteristics of the included studies are summarized in table 1.…”

Pericytes Promote Malignant Ovarian Cancer Progression in Mice and Predict Poor Prognosis in Serous Ovarian Cancer Patients

“…Our data demonstrate that placing pericytes in the tumor stroma of OVCAR-5 and -8 ovarian cancer cells while leaving the tumor vasculature intact results in accelerated tumor expansion via increased cell proliferation, shortening the latency of OVCAR-8 tumors by 15 days. Moreover, pericytes induced invasion and metastatic spread in nonmetastatic OVCAR-8 cells-a core clinical feature of aggressive serous ovarian cancer (1,44,45), and faster, distal spread of OVCAR-5 cells compared with controls that metastasized only locally within the peritoneal cavity to the gastrointestinal tract. These data demonstrate that normal MSC-like pericytes placed in close proximity to ovarian cancer cells drive malignant conversion, while normal fibroblasts do not affect tumor growth or metastasis, as reported previously.…”

The clinical course and prognosis factors of stomach cancer patients with metastases in the ovaries

“…Г и н е к о л о г и я / G y n e c o l o g y признаков схожи с первичными опухолями этого ор-гана, что вызывает ряд трудностей в их обнаружении и распознавании, обусловливая высокую частоту кли-нико-диагностических ошибок [4,[10][11][12].…”

“…Они представляют собой группу заболеваний с неблагоприятным про-гнозом, однако он варьирует в зависимости от лока-лизации первичной опухоли. Наиболее часто в яич-ники метастазируют опухоли желудочно-кишечного тракта, при этом частота метастазирования рака же-лудка (РЖ) составляет от 16,0 до 40,8 % среди всех метастатических опухолей яичников [4][5][6][7]. Одной из наиболее распространенных метастатических опу-холей яичников является опухоль Крукенберга -мета-статическая перстневидно-клеточная аденокарцинома яичника, составляющая от 1 до 2 % всех опухолей яичников.…”