Clinical characteristics of Japanese reflux esophagitis patients as determined by Los Angeles classification

Inamori, Masahiko; Togawa, Jun‐Ichi; Nagase, Hajime; Abe, Yasunobu; Umezawa, Tadashi; Nakajima, Atsushi; Saito, Toshifumi; Ueno, Norio; Tanaka, Katsuaki; Sekihara, Hisahiko; Kaifu, Hiroki; Tsuboi, Hideo; Kayama, Hideyuki; Tominaga, Shizuo; Nishimura, Hiroshi

doi:10.1046/j.1440-1746.2003.02932.x

Cited by 61 publications

(81 citation statements)

References 18 publications

(29 reference statements)

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“…Today, the incidence of RE is reported to be 10%-20% in Europe and the United States [23][24][25] , and 14%-16% in Japan [26][27][28] . While the incidence of RE in Japan is considered low as compared to Europe and the United States, the incidence of RE in Japan has increased due to the westernization of the Japanese diet, the rapidly growing elderly population, and lower H pylori infection rates [26][27][28] . Parkman [5] has reported that the incidence of RE in patients was 20% (4/20).…”

Section: Discussionmentioning

confidence: 99%

“…In Japan, with respect to the severity of RE, most patients are reported to have mild esophagitis (Grade A or B under the Los Angeles classification [26,27] . In the present study, all patients had mild esophagitis.…”

Section: Discussionmentioning

confidence: 99%

“…Some investigators have reported that the incidence of RE is high in diabetic patients [5,6] , although few reports have examined the incidence of RE in diabetic patient in Japan. There are some reports that hiatal hernia, age, H pylori infection and body mass index (BMI) are considered to affect the outbreak of RE [7,8] . Recent studies have reported that H pylori infection was less prevalent in patients with RE than those without RE, and was considered to suppress the onset of RE by inducing gastric mucosal atrophy and lowering gastric acid secretion [9,10] .…”

Section: Introductionmentioning

confidence: 99%

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Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

Ariizumi

Koike²,

Ohara³

et al. 2008

WJG

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AIM:To investigate the incidence of reflux esophagitis (RE) and H pylori infection in the diabetic patient. METHODS: The incidence of RE and H pylori infection were investigated in 85 patients with diabetes mellitus and the results were compared with controls. RESULTS: The incidence of RE in diabetic patients was 17.6%. Although this tended to be higher in diabetic patients, there were no statistically significant differences between diabetic patients and controls.The incidence of H pylori infection in diabetic patients was 53.7% but no statistically significant difference was seen between diabetic patients and controls in the incidence of H pylori infection. CONCLUSION:No significant differences could be seen between diabetic patients and controls in the incidence of RE and H pylori infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

Ariizumi

Koike²,

Ohara³

et al. 2008

WJG

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“…Gastroesophageal reflux disease (GERD) is a common disease in Western countries [1][2][3], and the number of patients with GERD is increasing in Japan [4][5][6][7]. Gastric acid has an important role in the pathogenesis of GERD.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Meal and Genotype of CYP2C19 on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects

Shinkai¹,

Koike²,

Shimada³

et al. 2013

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Objectives: To evaluate the influence of meals on the pharmacokinetics of omeprazole and rabeprazole and to investigate these PPIs with reference to CYP2C19 genotypes in healthy Japanese men. Methods: This was a randomized, open label, four-way crossover study. Twelve healthy Japanese male volunteers received a single oral dose of either 20 mg omeprazole or 10 mg rabeprazole, in the fasted state and after a standardized breakfast. Results: Between the administration of omeprazole in the fasted state and after breakfast, there were no significant differences in Cmax, AUC, Tmax, and half-life. Between the administration of rabeprazole in the fasted state and after breakfast, there were no significant differences in Cmax, AUC and half-life, whereas the Tmax of rabeprazole after breakfast was significantly delayed (2.8 ± 1.0 vs 5.3 ± 1.8 h, respectively; p = 0.006). PMs demonstrated the highest Cmax and AUC after drug intake under the fasting state and after breakfast, and homo EMs showed a significantly delayed Tmax. Conclusion: When a single dose of either PPI was administered, the pharmacokinetics of omeprazole was not affected by the meal, whereas the Tmax of rabeprazole after the meal was significantly delayed.

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“…Male sex, old age (>65 years old), hiatal hernia, smoking, alcohol, Caucasian race, and obesity are independent risk factors associated with asymptomatic esophagitis (8,(15)(16)(17). Atrophy, Helicobacter pylori infection, and peptic ulcer are not considered to be risk factors for provoking asymptomatic EE, while there are varying reports of association between BMI and asymptomatic EE (7,8,18).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and natural history of asymptomatic erosive esophagitis

Jung

Oh²,

Kang³

2014

Turk J Gastroenterol

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Clinical characteristics of Japanese reflux esophagitis patients as determined by Los Angeles classification

Abstract: We observed that age, hiatal hernia and a lower rate of gastric mucosal atrophy were associated with the proportion of mucosal breaks accompanying esophagitis.

Cited by 61 publications

References 18 publications

Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

Influence of the Meal and Genotype of CYP2C19 on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects

Clinical characteristics and natural history of asymptomatic erosive esophagitis

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