Clinical characteristics of idiopathic pulmonary fibrosis patients according to their smoking status

Kishaba, Tomoo; Nagano, Hiroaki; Nei, Yuichiro; Yamashiro, Satoshi

doi:10.21037/jtd.2016.03.89

Cited by 33 publications

(29 citation statements)

References 41 publications

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“…Annual decline of the main physiological pulmonary parameters in our cohort of iPF patients. often encounter approximately 30% never-smoking IPF patients [17]. In our study, we confirm the male predominance with a mean age of 71 years, and 27% of the all population had never smoked.…”

Section: Hospitalizationssupporting

confidence: 85%

Clinical experience in idiopathic pulmonary fibrosis: a retrospective study

Guiot

Duysinx

Seidel³

et al. 2017

Acta Clinica Belgica

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Introduction: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease with an increased incidence since the last few years. Here, we report our eight-year clinical experience in CHU of Liège, Belgium. Methods: We have studied retrospectively patients recruited from our ambulatory care polyclinic at CHU of Liège from 1 January 2009 to 1 January 2017. We have excluded all patients treated with a specific anti-fibrotic therapy due to incomplete follow-up. The diagnosis of IPF was made according to the ATS/ERS international recommendations (2015). Results: Out of the 114 patients initially selected, 82 cases were found to be suitable for the analysis. The average age was 71.1 ± 9.35 years with a male predominance. The median survival was 43.7 months (23.6-71.7) with a majority (45%) of patients in the group II of the GAP index. The median rate of annual decline in diffusion capacity of CO (DLCO) was 11%, whereas the sub analysis for group III (according to GAP index) showed a decrease annual rate of 30%. Conclusion: Our results are in keeping with the literature. One of our major finding is that patients in GAP III exhibit an annual rate of mortality of 42% and a median annual decline in DLCO of 30%. This observation highlights the fact that this specific subgroup of patients presents a high risk of morbi-mortality.

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Section: Hospitalizationssupporting

confidence: 85%

Clinical experience in idiopathic pulmonary fibrosis: a retrospective study

Guiot

Duysinx

Seidel³

et al. 2017

Acta Clinica Belgica

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“…Accurate cause of all stage III patients was never smoker remains unknown. According to our previous report, never smoker IPF patients had poor prognosis (53), therefore one possibility is never smoker IPF patients tend to have pure active fibrosis compared to smoker IPF patients. Detailed evaluation of pathological findings is interesting topic.…”

Section: Discussionmentioning

confidence: 92%

“…Among IPF patients, we previously reported that 1-year modified medical research council breathlessness scale is a useful predictor of mortality (53). In IPF patients, severe dyspnea is associated with greater consumption of body energy.…”

Section: Discussionmentioning

confidence: 99%

“…We considered that respiratory hospitalization such as bronchitis, pneumonia, pneumothorax and pulmonary embolism would contribute more to prognosis of IPF patients. IPF patients often develop respiratory deterioration or pulmonary dysfunction within 1-year of diagnosis (53). Therefore, we set 1-year as the cut-off for evaluating the trend of significant parameters or hospitalization history.…”

Section: Discussionmentioning

confidence: 99%

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Body mass index—percent forced vital capacity—respiratory hospitalization: new staging for idiopathic pulmonary fibrosis patients

Kishaba¹,

Nagano²,

Nei³

et al. 2016

J. Thorac. Dis.

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“…All participants were screened for breathlessness using the modified Medical Research Council (mMRC) score [16]. Participants were graded from 0 to 4 depending on breathlessness-related activities reported.…”

Section: Methodsmentioning

confidence: 99%

Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes

Kopf

Groener²,

Κender³

et al. 2018

Respiration

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Background: Diabetes mellitus is a significant comorbidity of interstitial lung disease (ILD). Objectives: The aim of this study was to investigate the incidence of restrictive lung disease (RLD) and ILD in patients with prediabetes and type 2 diabetes (T2D). Methods: Forty-eight nondiabetics, 68 patients with prediabetes, 29 newly diagnosed T2D, and 110 patients with long-term T2D were examined for metabolic control, diabetes-related complications, breathlessness, and lung function. Five participants with T2D, breathlessness, and RLD underwent multidetector computed tomography (MDCT) and a Six-Minute Walk Test (6MWT). Lung tissue from 4 patients without diabetes and from 3 patients with T2D was histologically examined for presence of pulmonary fibrosis. Results: Breathlessness in combination with RLD was significantly increased in patients with prediabetes and T2D (p < 0.01). RLD was found in 9% of patients with prediabetes, in 20% of patients with newly diagnosed T2D, and in 27% of patients with long-term T2D. Thus, patients with long-term T2D had an increased risk of RLD (OR 5.82 [95% CI 1.71–20.5], p < 0.01). RLD was significantly associated with glucose metabolism and albuminuria (p < 0.01); furthermore, presence of nephropathy increased the risk of RLD (OR 8.57 [95% CI 3.4–21.9], p < 0.01) compared to nondiabetics. MDCT revealed ILD in 4 patients, the 6MWT correlated with the extent of ILD, and histological analysis showed fibrosing ILD in patients with T2D. Conclusions: This study demonstrates increased breathlessness and a high prevalence of RLD in patients with T2D, indicating an association between diabetes and fibrosing ILD.

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Clinical characteristics of idiopathic pulmonary fibrosis patients according to their smoking status

Cited by 33 publications

References 41 publications

Clinical experience in idiopathic pulmonary fibrosis: a retrospective study

Clinical experience in idiopathic pulmonary fibrosis: a retrospective study

Body mass index—percent forced vital capacity—respiratory hospitalization: new staging for idiopathic pulmonary fibrosis patients

Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes

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