Clinical Characteristics of <i>Corynebacterium ulcerans</i> Infection, Japan

Yamamoto, Akihiko; Hifumi, Toru; Ato, Manabu; Iwaki, Masaaki; Senoh, Mitsutoshi; Hatanaka, Akio; Nureki, Shin-ichi; Noguchi, Yoshihiro; Hirose, Tomoko; Yoshimura, Yukihiro; Urakawa, Takaaki; Hori, Shinsuke; H., Nakada,; Terada, Tomomasa; Ishifuji, Tomoko; Matsuyama, Hisayo; Kinebuchi, Takahiro; Fukushima, Atsuhito; Wake, Koji; Otsuji, Ken; Endo, Takayoshi; Toyoshima, Hirokazu; Yasuda, Ikkoh; Tanaka, Takeshi; Takahashi, Naoki; Okada, Kensaku; Hayashi, Toshimasa; Kusano, Takashi; Koriyama, Minami; Otani, Norio; Takahashi, Motohide

doi:10.3201/eid2908.220058

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Patients with these cutaneous symptoms were significantly younger (mean age 38) than patients presenting with predominantly respiratory symptoms (mean age 64). 5 Macrolides or penicillins are the antibiotic of choice, with severe cases requiring administration of diphtheria antitoxin. 5 with prior exposure to antifungal agents.…”

Section: Corynebacterium Ulceransmentioning

confidence: 99%

“…5 Macrolides or penicillins are the antibiotic of choice, with severe cases requiring administration of diphtheria antitoxin. 5 with prior exposure to antifungal agents. 6,7 C. auris is particularly concerning due to its resistance to multiple drugs, rendering commonly used treatments, such as fluconazole, ineffective.…”

Section: Corynebacterium Ulceransmentioning

confidence: 99%

“…Nonrespiratory symptoms of C. ulcerans infection include plantar skin ulcers, subcutaneous abscesses, localized lymph node abscesses, and/or parotid, axillary, or mandibular abscesses. Patients with these cutaneous symptoms were significantly younger (mean age 38) than patients presenting with predominantly respiratory symptoms (mean age 64) 5 . Macrolides or penicillins are the antibiotic of choice, with severe cases requiring administration of diphtheria antitoxin 5 …”

Section: Emerging Bacterial Infections Of the Skinmentioning

confidence: 99%

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Emerging skin infections: A clinical update

Malick,

Shahinfar,

Jabin

et al. 2023

Dermatological Reviews

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| EMERGING BACTERIAL INFECTIONS OF THE SKIN 1.1 | Burkholderia pseudomallei B. pseudomallei (gram-negative rod) is the pathogen responsible for Melioidosis, which has spread throughout nonendemic areas recently. 1 The bacteria are spread via contaminated soil and water to humans. Old age and diabetes pose a greater threat to spread of the disease. 1 Patients typically present with pneumonia or sepsis symptoms, however, 10%-25% patients may also display concomitant cutaneous manifestations such as pustules, cellulitis, ulceration, or subcutaneous abscesses, without an identifiable pattern of distribution 1 If skin biopsies are taken,

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Section: Corynebacterium Ulceransmentioning

confidence: 99%

Section: Corynebacterium Ulceransmentioning

confidence: 99%

Section: Emerging Bacterial Infections Of the Skinmentioning

confidence: 99%

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Emerging skin infections: A clinical update

Malick,

Shahinfar,

Jabin

et al. 2023

Dermatological Reviews

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Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023

Zink,

Hofer,

Schneider

et al. 2024

Infection

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Objectives From September 2022 an increase in Corynebacterium diphtheriae (C. diphtheriae) infections was reported in Europe. Our study focuses on 31 adolescent and young adult refugees with cutaneous C. diphtheriae infections detected in Germany. We examined treatment regimens and outcomes to provide targeted insights into the management of this infection. Methods We distributed a standardized survey, focused on children and adolescents presenting to paediatric clinics through the German Paediatric Infectious Diseases Society (DGPI) and additional professional contacts in Germany. Data were extracted from routine medical documentation and reported anonymously. Results A total of 31 individuals with cutaneous C. diphtheriae infection were reported by 9 centres. Two of these showed diphtheria toxin (DT) related systemic symptoms and four exhibited systemic inflammation requiring complex management. The remaining 25 cases, with exclusively cutaneous manifestations, were afebrile. Treatment with topical antiseptics and systemic antibiotics, mainly aminopenicillin/beta-lactamase inhibitors (BLI) (35%) or clindamycin (25%), achieved eradication in all but two cases treated with aminopenicillin/BLI. Treatment duration varied between 5 and 17 days. Conclusions In refugees presenting with chronic skin wounds, C. diphtheriae should be included into the differential diagnosis. Fever seems to be a valuable marker to differentiate severe cases with potentially DT-mediated sequelae from exclusively cutaneous diphtheria (CD). For afebrile CD, topical antiseptics and oral antibiotic therapy with clindamycin for 7 days, followed by clinical surveillance appears to be a safe treatment regimen. Patients with CD who present with fever or pharyngitis should be thoroughly investigated including blood and pharyngeal swab cultures.

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Clinical Characteristics of Corynebacterium ulcerans Infection, Japan

Abstract: Incidence has been increasing markedly, and the case-fatality rate is 5.9%.

Cited by 2 publications

References 21 publications

Emerging skin infections: A clinical update

Emerging skin infections: A clinical update

Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023

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