Clinical characteristics of Hepatoid adenocarcinoma of the lung: Four case reports and literature review

Zhuansun, Yongxun; Bian, Lijuan; Zhao, Zhenzhen; Du, Yumo; Chen, Rui; Lin, Lin; Li, Jianguo

doi:10.1016/j.ctarc.2021.100474

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…In recent years, some patients without elevated AFP levels have occasionally appeared. Most of the lesions in patients with primary HAL appear in the upper lobe of the lung, resulting in the symptoms and imaging findings of the patients being very similar to those of other types of lung cancer, but HE and immunohistochemical staining of the tumor pathology showed HCC-like features (Zhuansun et al, 2021). Therefore, to avoid misdiagnosis, CT examination and HE and immunohistochemical staining should be conducted together to help in the diagnosis (Terracciano et al, 2003).…”

Section: Discussion Interpretationmentioning

confidence: 99%

“…Second, if it expresses markers of liver differentiation, the abnormality in the patient should be diagnosed as HAL, no matter the AFP level is elevated or not. A thorough review of the published cases showed that patients with early diagnosis of HAL had longer postoperative survival, and the current treatment for HAL is the same as that for other lung cancers; radiotherapy and chemotherapy are effective treatments for patients with advanced HAL (Zhuansun et al, 2021). However, owing to the lack of analysis of gene mutations in HAL cases, the progress of new gene-targeted therapy has been limited.…”

Section: Discussion Interpretationmentioning

confidence: 99%

“…The incidence of HAL is much higher in middle-aged and older male smokers than in women. Because of the nonspecific symptoms and difficulty in diagnosis, most patients are diagnosed with HAL after the disease has progressed to an intermediate or advanced stage (Zhuansun et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Whole-exome sequencing and bioinformatics analysis of a case of non-alpha-fetoprotein-elevated lung hepatoid adenocarcinoma

et al. 2022

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Hepatoid adenocarcinoma of the lung (HAL) is an exceptionally rare malignant tumor with prominent hepatocellular carcinoma (HCC)-like characteristics in organs or tissues outside the liver, while there is no tumor in the liver. Most HAL cases have various degrees of serum alpha-fetoprotein (AFP) levels and exhibit a similar origin and clonal evolution process to HCC. We studied a case of HAL without elevating the AFP level by performing whole-exome sequencing (WES) and bioinformatics analyses after surgical resection. Our results showed mutations in two driver genes, NLRP3 and PBX1, and we identified HNRNPR, TP73, CFAP57, COL11A1, RUSC1, SLC6A9, DISC1, NBPF26, and OR10K1 as potential driver mutation genes in HAL. In addition, 76 significantly mutated genes (SMG) were identified after the statistical test of each mutation type on genes.

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Section: Discussion Interpretationmentioning

confidence: 99%

Section: Discussion Interpretationmentioning

confidence: 99%

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Whole-exome sequencing and bioinformatics analysis of a case of non-alpha-fetoprotein-elevated lung hepatoid adenocarcinoma

et al. 2022

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“…Moreover, HAL is mainly diagnosed by histopathology and immunohistochemistry, which must rule out primary HCC or other HAC metastasis to the lungs. 9,10 Due to non-specific clinical manifestations, HAL is often diagnosed at its advanced stage (stage III or IV), thereby resulting in shorter survival time. 7 HAL patients who undergo surgery have an average life expectancy between 7 months and 7 years and a 1-year survival rate of 55%.…”

Section: Discussionmentioning

confidence: 99%

“…HAL is indicated mainly by imaging that shows inhomogeneous masses in the upper lung fields; enhanced CT scans reveal homogeneous or heterogeneous density 5,8,9 . Thus, HAL is difficult to distinguish from other malignant tumours in the lung by imaging alone.…”

Section: Discussionmentioning

confidence: 99%

A rare case of hepatoid adenocarcinoma of the lung

Sun,

Liu,

et al. 2023

Clinical Respiratory J

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Hepatoid adenocarcinoma of the lung is a special type of primary origin in the lung with obvious pathological features and short survival time. However, standard treatment guidelines have not yet been established. Herein, we report a case of hepatoid adenocarcinoma with the primary lesion located in the left upper lung. The tumour size was reduced after four cycles of combined therapy. Subsequent postoperative pathology confirmed complete remission.

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High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis

Takayama-Isagawa,

Kanetaka,

Kobayashi

et al. 2024

Sci Rep

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Liver metastasis in gastric cancer is incurable. Alpha-fetoprotein-producing gastric cancer has a poor prognosis and is prone to liver metastasis. We investigated the association between preoperative serum alpha-fetoprotein levels, liver metastasis, and expression of primitive enterocyte phenotype markers. We reviewed the medical records of 401 patients with gastric cancer who underwent curative surgical resection and immunohistochemically evaluated the primitive phenotype markers. The preoperative serum alpha-fetoprotein levels were elevated and normal in 8 and 393 patients, respectively. Liver metastasis was more frequent in patients with higher preoperative alpha-fetoprotein levels. The 5-year postoperative recurrence-free survival and overall survival rates were significantly worse in patients with higher preoperative serum alpha-fetoprotein levels. Although alpha-fetoprotein and Glypican3 and Spalt-like transcription factor 4 tended to be stained with high preoperative serum alpha-fetoprotein levels, these markers were also positive in some patients with normal alpha-fetoprotein levels. In summary, patients with gastric cancer and high preoperative serum alpha-fetoprotein levels have a poor prognosis and high incidence of liver metastasis. Alpha-fetoprotein can help detect liver metastasis relating to the primitive enterocyte phenotype.

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Clinical characteristics of Hepatoid adenocarcinoma of the lung: Four case reports and literature review

Cited by 6 publications

References 34 publications

Whole-exome sequencing and bioinformatics analysis of a case of non-alpha-fetoprotein-elevated lung hepatoid adenocarcinoma

Whole-exome sequencing and bioinformatics analysis of a case of non-alpha-fetoprotein-elevated lung hepatoid adenocarcinoma

A rare case of hepatoid adenocarcinoma of the lung

High serum alpha-fetoprotein and positive immunohistochemistry of alpha-fetoprotein are related to poor prognosis of gastric cancer with liver metastasis

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