Clinical characteristics of Guillain-Barré syndrome in a tropical country: a Brazilian experience

Dourado, Mário Emílio; Felix, Ricardo H M; Silva, W. K. A. da; Queiroz, José W.; Jerônimo, Selma M. B.

doi:10.1111/j.1600-0404.2011.01503.x

Cited by 48 publications

(44 citation statements)

References 38 publications

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“…As it has been previously reported in other South American countries [47][48][49], the most frequent subphenotype reported in Colombia was AIDP. Conversely, in Mexico AMAN subphenotype is the most frequently observed [50].…”

Section: Discussionsupporting

confidence: 55%

Guillain–Barré syndrome in Colombia: where do we stand now?

Mahecha

Ojeda²,

Vega³

et al. 2016

Immunol Res

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Guillain-Barré syndrome (GBS) is a rapid-onset muscle weakness disease caused by the immune-mediated damage of the peripheral nervous system. Since there is an increase incidence of GBS cases in Latin America, particularly in Colombia, and most of them are currently preceded by Zika virus (ZIKV) infection, we aimed to assess the available evidence of the disease in Colombia through a systematic literature review. Out of 51 screened abstracts, only 16 corresponded to articles that met inclusion criteria, of which 15 were case reports or case series. A total of 796 cases of GBS were reported in the included articles. The majority of patients were males (66.8 %) and younger than 50 years old (94 %). An infectious disease before the onset of GBS was registered in 31 % of patients, with gastrointestinal or respiratory symptoms being the most frequently observed. In those cases in which electrodiagnostic tests were performed, the most common subphenotype was acute inflammatory demyelinating polyneuropathy (17 %). Death was reported in 15 % of patients. Data regarding GBS in Colombia is scant and heterogeneous. Taking into account the burden of the disease and the recent rise of GBS cases associated with ZIKV, a careful patient evaluation and a systematic collection of data are warranted. A form to data gathering is proposed.

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Section: Discussionsupporting

confidence: 55%

Guillain–Barré syndrome in Colombia: where do we stand now?

Mahecha

Ojeda²,

Vega³

et al. 2016

Immunol Res

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“…3 Tropical pathogens such as flaviviruses are potentially able to affect the nervous system, but most of these neurological manifestations are encephalitic. 4 Only a few sporadic cases of GBS have been reported secondary to dengue virus (DENV) infection, 5,6 West Nile virus (WNV) infection, 7 and Japanese encephalitis virus (JEV) outbreaks. 8 …”

Section: Introductionmentioning

confidence: 99%

Guillain–Barré Syndrome (42 Cases) Occurring During a Zika Virus Outbreak in French Polynesia

et al. 2016

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Zika virus (transmitted by mosquitoes) reached French Polynesia for the first time in 2013, leading to an epidemic affecting 10% of the total population. So far, it has not been known to induce any neurological complications, but, a few weeks after the outbreak, an unexpectedly high number of 42 patients presented with Guillain–Barré syndrome.We report the clinical and electrophysiological characteristics of this series. Males predominated with a sex ratio of 2.82 (mean age: 46). All patients (except 2) were native Polynesian. At admission, 55% were able to walk unaided against 38% at nadir, 24% had swallowing troubles (nadir: 45%), 74% had motor weakness of the limbs (nadir: 86%) and deep tendon reflexes were diminished or not found in the vast majority of patients. Mean duration of the progressive phase and of the plateau phase was respectively 7 and 9 days. Thirty-eight percent of the patients were admitted in intensive care unit and 10 patients underwent tracheotomy. Nerve electrophysiological studies at admission showed marked distal motor conduction alterations, which had almost completely disappeared at the 4th month; this pattern was more suggestive of acute motor axonal neuropathy (AMAN) than of acute inflammatory demyelinating polyneuropathy (AIDP). Lumbar puncture showed elevated proteins in 90% of the cases, with cell count always inferior to 50/μL.This epidemic raises several questions, such as the potential existence of interactions between Zika virus and Polynesian HLA system and/or the consequences of several recombination events of this virus. This situation should call for increased vigilance, especially in countries where Aedes mosquitoes are present.

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“…It has been documented that AMAN is more common in Japan, China, and some countries in Central and South America . In contrast, studies conducted in Brazil and Chile reported a higher prevalence of AIDP in adults . This difference may be related to genetic variations associated with diverse ancestries in South American countries.…”

Section: Discussionmentioning

confidence: 96%

Clinical and electrophysiological characteristics of Guillain‐Barré syndrome in Colombia

Gómez

Díaz

Carrión‐Penagos

et al. 2019

J Peripheral Nervous Sys

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Despite the wide literature describing the features of Guillain‐Barré syndrome (GBS) in different populations worldwide, Colombian data are very scarce. We aim to characterize patients with GBS in a general hospital setting in Colombia. We conducted a retrospective chart review of GBS cases managed at the Hospital Universitario Fundación Santa Fe de Bogotá, from 2011 to 2016. Twenty‐three patients were included. The most commonly reported symptoms were paresthesias (65%), pain (61%), proximal (22%) and distal (74%) limb weakness, and facial palsy (30%). 9% of patients had Fisher syndrome and 21% had other variants: Bickerstaff, pharyngeal‐cervical‐brachial pattern, and facial diplegia. There was a predominance of the demyelinating form (70%), with only 22% of patients presenting with the axonal variants. Our results are concordant with previous studies in Colombia.

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Clinical characteristics of Guillain-Barré syndrome in a tropical country: a Brazilian experience

Abstract: A predominance of the AIDP variant was seen, and the incidence of the disease decreased with age. As expected, the distribution of weakness correlated with the clinical variants, and individuals with the axonal variant had a poorer prognosis.

Cited by 48 publications

References 38 publications

Guillain–Barré syndrome in Colombia: where do we stand now?

Guillain–Barré syndrome in Colombia: where do we stand now?

Guillain–Barré Syndrome (42 Cases) Occurring During a Zika Virus Outbreak in French Polynesia

Clinical and electrophysiological characteristics of Guillain‐Barré syndrome in Colombia

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