Clinical Characteristics of Exudative Age-related Macular Degeneration in Japanese Patients

Maruko, Ichiro; Iida, Tomohiro; Saito, Masaaki; Nagayama, Dai; Saito, Katsuharu

doi:10.1016/j.ajo.2007.03.047

Cited by 484 publications

(367 citation statements)

References 31 publications

Supporting

Mentioning

328

Contrasting

Unclassified

Order By: Relevance

“…Other studies in Caucasians and Asians, however, do not report a significant difference in age of presentation between PCV and CNV. [8][9][10] Both PCV and CNV groups showed a higher preponderance of males, which is comparable to other studies of serosanguineous maculopathy in Asians. 8,9 Absence of drusen in the fellow eye is a recognized feature of PCV.…”

Section: Discussionsupporting

confidence: 78%

“…[8][9][10] Both PCV and CNV groups showed a higher preponderance of males, which is comparable to other studies of serosanguineous maculopathy in Asians. 8,9 Absence of drusen in the fellow eye is a recognized feature of PCV. 4 In our study, ARM was found in the unaffected fellow eye in significantly more patients with CNV than PCV (Po0.001).…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Cackett

Htoon

Wong

et al. 2009

Eye

View full text Add to dashboard Cite

Purpose To determine the frequency of haemorrhagic pigment epithelial detachment (PED) among patients presenting with either polypoidal choroidal vasculopathy (PCV) or choroidal neovascularization (CNV) and calculate the degree to which the presence of a haemorrhagic PED can be used to predict the diagnosis of PCV. Methods A retrospective review of 290 eyes of 253 patients presenting to the Singapore National Eye Centre with serosanguineous maculopathy. Patients underwent ophthalmologic examination including digital colour fundus photography and stereoscopic fluorescein angiography and indocyanine green angiography (ICGA). Classification into PCV or CNV was based on ICGA findings, and presence or absence of haemorrhagic PED was documented. Results In total, 138 eyes of 123 patients were diagnosed with PCV and 152 eyes of 130 patients with CNV. A haemorrhagic PED was a significantly more common (Po0.001) presenting feature in PCV eyes (63, 45.7%) than CNV eyes (6, 3.9%) (odds ratio (OR) 20.4, 95% confidence interval (CI) 8.5-49.4). Age-related maculopathy was found significantly more frequently (Po0.001) in the unaffected fellow eye of CNV patients (57, 52.8%) than PCV patients (28, 22.8%) (OR 3.2, 95% CI 1.8-5.7). Conclusions In patients of Chinese ethnicity, a haemorrhagic PED is significantly more likely to be the presenting feature of PCV than CNV. Patients presenting with this clinical feature should make the clinician suspicious of an underlying diagnosis of PCV.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 78%

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Cackett

Htoon

Wong

et al. 2009

Eye

View full text Add to dashboard Cite

show abstract

“…6,11 Indeed, PCV is a distinct clinical entity, 9 although some advanced AMD cases do show features characteristic of PCV. 33 Limitations of the current study are its retrospective nature and the various treatment regimens used. In the current study, active AMD sometimes showed polypoidal lesions at the terminus of the vascular lesion, when the neovascularization showed progression in the subretinal pigment epithelium space.…”

Section: Discussionmentioning

confidence: 99%

“…As their patients had PCV lesions in the fellow eye, it is reasonable to assume that these eyes originally had PCV but did not meet the diagnostic criteria of PCV. 33 Our patients had been examined with both FA and IA for more than 2 years after the initial visit. In the current study, the rate of those eyes that were refractory to treatment or that showed a recurrence of CNV after the successful initial treatment might be relatively high.…”

Section: Discussionmentioning

confidence: 99%

Development of polypoidal lesions in age-related macular degeneration

Tsujikawa

Ojima

Yamashiro

et al. 2011

Eye

View full text Add to dashboard Cite

Purpose To investigate the development of polypoidal lesions using indocyanine green angiography (IA) in eyes with typical age-related macular degeneration (AMD). Methods We retrospectively reviewed the medical records of 47 consecutive patients (47 eyes) with typical AMD who had been followed up with IA for at least 2 years. Results At the initial visit, although all eyes showed classic and/or occult choroidal neovascularization (CNV) associated with AMD, no eyes showed polypoidal lesions by IA. However, during follow-up, 13 (27.7%) of the 47 eyes did show polypoidal lesions. All polypoidal lesions developed at the edge of persistent CNV or, more often, at the terminus of recently progressed CNV. Of 12 eyes with a final lesion area 48 disc area, 7 (58.3%) showed newly developed polypoidal lesions. In the eyes with these newly developed polypoidal lesions, the mean area of the vascular lesion had extended significantly from 10.50±7.88 mm 2 to 20.87±10.21 mm 2 during follow-up (P ¼ 0.0018). Conclusion The current observation suggests that IA of active AMD sometimes reveals polypoidal lesions if there is progression of the CNV in the subretinal pigment epithelium space.

show abstract

“…Indocyanine green angiography (ICGA) clearly shows the abnormal vascular structure, which is important for definitively diagnosing PCV. [1][2][3][4] The branching vascular network often appears as a plaque on ICGA and regarded as type 1 CNV. 2,3 PCV is highly prevalent in Asian patients with age-related macular degeneration (AMD) and also develops in Caucasian patients.…”

Section: Introductionmentioning

confidence: 99%

Two-year results of intravitreal ranibizumab for polypoidal choroidal vasculopathy with recurrent or residual exudation

Saito

Iida

Kano

et al. 2013

Eye

View full text Add to dashboard Cite

Aim To clarify the 2-year efficacy of ranibizumab for patients with polypoidal choroidal vasculopathy (PCV) with recurrent or residual exudation from branching vascular networks after previous photodynamic therapy (PDT). Methods We retrospectively reviewed 26 eyes of 26 Japanese patients (22 men, 4 women) in this pilot study. All eyes had PCV with complete regression of polypoidal lesions resulting from PDT detected by indocyanine green angiography (ICGA), but recurrent or residual leakage from branching vascular networks on fluorescein angiography and evidence of persistent fluid on optical coherence tomography (OCT). Three consecutive intravitreal injections of ranibizumab (0.5 mg/0.05 ml) were administered to all eyes. Results The mean logarithm of the minimum angle of resolution best-corrected visual acuity (BCVA) improved significantly from 0.55 at baseline to 0.35 at 12 months (Po0.0001) and 0.43 at 24 months (P ¼ 0.0012). The mean increases in the BCVA 12 and 24 months after baseline were 1.95 and 1.23 lines, respectively. The mean central retinal thickness significantly decreased from 295 mm at baseline to 189 mm at 12 months (Po0.0038) and 163 mm at 24 months (Po0.001). The mean numbers of intravitreal ranibizumab (IVR) injections at months 12 and 24, including the initial treatments, were 5.8 and 8.8, respectively. Five (19.2%) eyes had recurrent polypoidal lesions on ICGA at a mean of 15.7 months after baseline. At month 24, OCT showed no exudation in 17 (65.4%) of the 26 eyes. No adverse events developed.Conclusions IVR injections maintained or improved the VA and retinal thickness at 24 months in eyes with PCV with recurrent or residual exudation from branching vascular networks after previous PDT.

show abstract

Clinical Characteristics of Exudative Age-related Macular Degeneration in Japanese Patients

Cited by 484 publications

References 31 publications

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Haemorrhagic pigment epithelial detachment as a predictive feature of polypoidal choroidal vasculopathy in a Chinese population

Development of polypoidal lesions in age-related macular degeneration

Two-year results of intravitreal ranibizumab for polypoidal choroidal vasculopathy with recurrent or residual exudation

Contact Info

Product

Resources

About