Clinical characteristics of essential tremor in Mersin, Turkey

Doğu, Okan; Louis, Elan D.; Sevim, Serhan; Kaleağası, Hakan; Aral, Mihriban

doi:10.1007/s00415-005-0700-8

Cited by 88 publications

(72 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditionally, psychiatric symptoms have been regarded as occurring in response to debilitating neurological symptoms in ET [Chatterjee et al 2004]. However, other evidence suggests that depression might occur before the motor symptoms of ET manifest; in such situations this psychiatric disorder cannot be a secondary response to disability [Louis, 2010a;Louis et al 2007a;Dogu et al 2005].The pathophysiological basis of depression and anxiety in patients with ET is currently unknown and awaits prospective studies. Importantly, however, depression does not appear to account for cognitive deficits in ET [Li et al 2011].…”

Section: Association Of Et With Psychiatric Disordersmentioning

confidence: 99%

The cognitive side of essential tremor: what are the therapeutic implications?

Janicki

Cosentino

Louis

2013

Ther Adv Neurol Disord

View full text Add to dashboard Cite

While essential tremor (ET) has traditionally been categorized as a pure motor disease, cross-sectional and longitudinal studies of cognition in ET have demonstrated that these patients may have cognitive dysfunction. Recent epidemiological studies demonstrate an association between ET (particularly with onset after age 65) and increased risk for cognitive impairment and dementia. Although existing studies have generally conceptualized cognitive changes in ET as consistent with a 'frontosubcortical' or 'corticocerebellar' profile, results from these same studies suggest that cognitive impairment in ET may in fact be heterogeneous. Furthermore, the underlying mechanisms remain uncertain. Cognitive changes could be a byproduct of the cerebellar dysfunction of ET itself; alternately, they may be a feature of concomitant neurodegenerative diseases that have been associated in several studies with ET, including Alzheimer's disease, Parkinson's disease or progressive supranuclear palsy. While the study of cognitive dysfunction in ET has received research attention in recent years, the results of these studies have not been translated into the clinical domain and clinical practice. This review first summarizes the current literature on the potential relationships between ET and cognitive change. We then suggest areas of further clinical evaluation and treatment; these suggestions are directed at physicians caring for ET patients who may demonstrate or complain of cognitive impairment. As we discuss, clinicians should ideally screen ET patients for possible signs or symptoms of cognitive impairment in addition to assessing for psychiatric comorbidity and quality of life. These recommendations are in contrast to most current clinical practice, which does not routinely include such assessment among ET patients. To our knowledge, there have been no pharmacotherapeutic trials to date of any agent for cognitive change associated with ET. We believe that studies for this indication are now called for. Future efforts in this direction will also need to take into account the pathobiology of cognitive changes in ET, which itself is an area that is ripe for future investigations.

show abstract

Section: Association Of Et With Psychiatric Disordersmentioning

confidence: 99%

The cognitive side of essential tremor: what are the therapeutic implications?

Janicki

Cosentino

Louis

2013

Ther Adv Neurol Disord

View full text Add to dashboard Cite

show abstract

“…Usual activities, such as eating, drinking, and dressing may be hindered by the abnormal movement, which thus causes functional disability and social embarrassment to a varying degree. In addition, patients with ET are more likely to suffer from depression and anxiety than are controls [7]. Hence,…”

Section: Introductionmentioning

confidence: 99%

Most of the Quality of Life in Essential Tremor Questionnaire (QUEST) psychometric properties resulted in satisfactory values

Martinez‐Martín

Jiménez‐Jiménez

García

et al. 2010

Journal of Clinical Epidemiology

View full text Add to dashboard Cite

“…Essential tremor (ET) is highly prevalent in human populations [1][2][3][4][5] . Milder action tremor of the hands is also widespread and is far more common than ET [6] .…”

Section: Introductionmentioning

confidence: 99%

Tremor in School-Aged Children: A Cross-Sectional Study of Tremor in 819 Boys and Girls in Burgos, Spain

et al. 2011

View full text Add to dashboard Cite

Background: Mild hand tremor occurs in most normal adults. There are no surveys of the prevalence or clinical correlates of such tremor among children. Methods: A cross-sectional study of tics, tremor and other neurological disorders was conducted in Spanish children; thus, 819 schoolchildren in Burgos, Spain, drew Archimedes spirals with each hand. Tremor in spirals was rated (0–2) by a blinded neurologist and an overall tremor rating (0–4) was assigned. Results: The mean age was 10.9 ± 3.1 years. A tremor rating of 1 (mild tremor) was present in either hand in 424 (51.7%) children, and in both hands in 88 (10.7%) children. Higher tremor ratings were very uncommon. The overall tremor rating was higher in boys than girls (1.31 ± 0.41 vs. 1.22 ± 0.34, p = 0.002) and correlated weakly yet significantly with age (ρ = 0.09, p = 0.01). Within subjects, the left hand spiral rating was greater than the right (p < 0.001). Conclusions: In this cross-sectional study of 819 Spanish schoolchildren, mild tremor was commonly observed. As in adults, males had more tremor than females, tremor scores increased with age, and tremor scores were higher in the left than right arm, demonstrating that these clinical correlations seem to be more broadly generalizable to children. The functional significance of tremor in children, particularly as it relates to handwriting proficiency, deserves additional scrutiny.

show abstract

Clinical characteristics of essential tremor in Mersin, Turkey

Cited by 88 publications

References 26 publications

The cognitive side of essential tremor: what are the therapeutic implications?

The cognitive side of essential tremor: what are the therapeutic implications?

Most of the Quality of Life in Essential Tremor Questionnaire (QUEST) psychometric properties resulted in satisfactory values

Tremor in School-Aged Children: A Cross-Sectional Study of Tremor in 819 Boys and Girls in Burgos, Spain

Contact Info

Product

Resources

About