Clinical characteristics of COVID‐19 patients combined with allergy

Abstract

6. Li Q , Ding X , Xia G , et al. Eosinopenia and elevated C-reactive protein facilitate triage of COVID-19 patients in fever clinic: a retrospective case-control study. EClinicalMedicine. 2020 ;

Expression of ACE2 in airways: Implication for COVID‐19 risk and disease management in patients with chronic inflammatory respiratory diseases

“…higher circulating total T cell counts than those without allergy. 90 However, the relationship between allergy and COVID-19 obviously needs to be evaluated and validated in larger cohorts and those with different genetic and socio-economic backgrounds.…”

“…In a single‐centre retrospective study with a small sample size (110 COVID‐19 patients) in China, Shi et al observed a lower rate of comorbid allergy in patients with COVID‐19 in comparison with the prevalence of allergic diseases in the general population 90 . When excluding patients with other underlying diseases and stratifying COVID‐19 patients into those with (n = 21) and without allergy history (n = 44), they found that patients with allergy demonstrated lower proportions of bilateral lung lesions on chest computed tomography scanning and severe illness and higher circulating total T cell counts than those without allergy 90 . However, the relationship between allergy and COVID‐19 obviously needs to be evaluated and validated in larger cohorts and those with different genetic and socio‐economic backgrounds.…”

Asthma phenotypes, comorbidities, and disease activity in COVID‐19: The need of risk stratification

“…The data that protection may be dependent on type 2 immunity are derived from the higher percentage of asthmatics being atopic, 2 also reflected in the series of ~2500 patients regularly followed up in our Allergy Unit. Yu et al 3 provided preliminary evidence about this in a single‐center retrospective study, where COVID‐19 atopic patients had less severe infections, milder lung damage compared with age‐ and gender‐matched COVID‐19 controls.…”

Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses

“…Moreover, evidence of T cell activation, as indicated by generation of effector (CD45RA - CD62L - ) and central memory (CD45RA − CD62L + ) αβCD4 conv and CD8 + cells was reported among COVID-19 patients with mild or severe disease, suggesting that activation of T cells is inversely associated with severity of SARS-CoV-2 infection 11 . Other investigators reported that T cells in peripheral blood of COVID-19 patients with allergy were increased as compared to patients without allergies 12 . These preliminary clinical and laboratory observations along with our prior experimental evidence involving RNA viruses led us hypothesize that SARS-CoV-2 may share a degree of protein sequence homology to allergens, which may lead to the generation of cross-reactive T cell epitopes.…”