Clinical Characteristics of Children With Anti-N-Methyl-d-Aspartate Receptor Encephalitis After Japanese Encephalitis

Luo, Hanyu; Ding, Xiao; Li, Yuhang; Ma, Jianjun; Liu, Benke; Zhou, Lvli; Zheng, Yaxin; Jiang, Yan; Li, Xiujuan; Jiang, Li

doi:10.1016/j.pediatrneurol.2022.02.004

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…In our previous study, we found that patients with anti-NMDAR encephalitis after Japanese encephalitis had a significantly higher level of CSF protein when compared with classical anti-NMDAR encephalitis. However, there was no difference in CSF protein level between the acute stage of Japanese encephalitis and anti-NMDAR encephalitis ( 29 ). Thus, we speculated that increased CSF protein residual from the initial stage of viral encephalitis could be one of the reasons for this phenomenon.…”

Section: Discussionmentioning

confidence: 95%

External Assessment of the Anti-N-Methyl-D-Aspartate Receptor Encephalitis One-Year Functional Status Score in Chinese Pediatric Patients

Luo

Li²,

Zheng³

et al. 2022

Front. Immunol.

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Objectiveto assess the performance of the Anti-N-Methyl-D-Aspartate Receptor encephalitis (NMDAR) One-Year Functional Status (NEOS) score in predicting one-year functional outcome in Chinese children with anti-NMDAR encephalitis.Methodschildren with anti-NMDAR encephalitis at the Children’s Hospital of Chongqing Medical University were retrospectively enrolled from January 2014 to December 2020. Patients were categorized into two groups based on the modified Rankin Scale (mRS) at one-year follow-up. Discrimination of the NEOS score was assessed by the area under curve (AUC) of the receiver operating characteristic curve. Calibration of the NEOS score was assessed by comparing predicted probabilities with observed probabilities using a calibration curve and the Hosmer-Lemeshow test. The clinical practicability of the NEOS score was evaluated by performing a decision curve analysis.Resultsone hundred seventy-five children (101 females and 74 males) with anti-NMDAR encephalitis and a median age of 7.7 years were enrolled. Of those, 149 (85.1%) had a good outcome at 1 year (mRS ≤ 2), and the remaining 26 (14.9%) had a poor outcome (mRS > 2). Patients with a higher NEOS score had a significantly higher mRS at one-year follow-up [Spearman r = 0.3878, 95% confidence interval (CI): 0.2500-0.5103, P < 0.001]. The AUC of the NEOS score was 0.870 (95% CI: 0.801-0.938, P < 0.001). The observed probability and predicted probability showed moderate consistency in the calibration curve and the Hosmer-Lemeshow test (P = 0.912). The decision curve analysis showed that using the NEOS score to predict one-year outcomes could provide additional net benefit during clinical practice.Conclusionsthe NEOS score is a potentially reliable model to predict the one-year functional outcome in Chinese children with anti-NMDAR encephalitis.

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Section: Discussionmentioning

confidence: 95%

External Assessment of the Anti-N-Methyl-D-Aspartate Receptor Encephalitis One-Year Functional Status Score in Chinese Pediatric Patients

Luo

Li²,

Zheng³

et al. 2022

Front. Immunol.

Self Cite

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show abstract

“…Our previous studies confirmed that the reason for relapse in some children with biphasic JE was the development of anti-NMDAR encephalitis, which has an incidence of 5 % [ 7 , 8 ]. Further investigation showed that the median time between the onset of JE and anti-NMDAR encephalitis was 29 days, and these patients were prone to poor outcomes [ 9 ]. However, no study has been performed on the mechanism underlying this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…In 2017, we originally reported that children with Japanese encephalitis (JE) might develop anti-NMDAR encephalitis during convalescence [ 7 ]. We then reported the incidence and clinical features of children with JE-induced anti-NMDAR encephalitis [ 8 , 9 ]. Several other researchers also reported similar cases [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

A peptide from the Japanese encephalitis virus failed to induce the production of anti-N-methyl-d-aspartate receptor antibodies via molecular mimicry in mice

Luo,

Yang,

Yang

et al. 2024

Heliyon

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Tick-borne encephalitis as a trigger for anti-N-Methyl-d-aspartate receptor encephalitis

Gaist,

Nilsson,

Nissen

et al. 2024

Ticks and Tick-borne Diseases

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Clinical Characteristics of Children With Anti-N-Methyl-d-Aspartate Receptor Encephalitis After Japanese Encephalitis

Cited by 3 publications

References 31 publications

External Assessment of the Anti-N-Methyl-D-Aspartate Receptor Encephalitis One-Year Functional Status Score in Chinese Pediatric Patients

External Assessment of the Anti-N-Methyl-D-Aspartate Receptor Encephalitis One-Year Functional Status Score in Chinese Pediatric Patients

A peptide from the Japanese encephalitis virus failed to induce the production of anti-N-methyl-d-aspartate receptor antibodies via molecular mimicry in mice

Tick-borne encephalitis as a trigger for anti-N-Methyl-d-aspartate receptor encephalitis

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