Clinical Characteristics of Children With COVID-19 in the United Arab Emirates: Cross-sectional Multicenter Study

Ennab, Farah; ElSaban, Mariam; Khalaf, Eman; Tabatabaei, Hanieh; Khamis, Amar Hassan; Devi, Bindu Radha; Hanif, Kashif; Elhassan, Hiba; Saravanan, Ketharanathan; Cremonesini, David; Popatia, Rizwana; Malik, Zainab; Ho, Samuel B.; Abusamra, Rania

doi:10.2196/29049

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…21,22 Most studies from neighboring regions extrapolated infant data from a pool of pediatric data and did not dedicate a study characterizing SARS-CoV-2 in infants alone. [23][24][25][26] In a multicenter study from Israel utilizing a prospective surveillance network including 20 of the country's 26 hospitals, 75 infants were examined, with 96% of the pooled cohort having described a benign disease course and favorable outcomes. 27 In another multicenter prospective study from Turkey 28 examining data from 24 neonatal ICUs, 37 symptomatic neonates were included.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Outcomes of COVID-19 in Newborns and Infants: A Multicenter Experience of 576 Cases

Dhaheri¹,

Dannan²,

Hashim³

et al. 2023

Pediatric Infectious Disease Journal

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Background: The literature describing clinical presentation, disease course and outcomes of SARS-CoV-2 in infants remains scarce. Methods: We conducted a retrospective study across 2 major pediatric referral centers evaluating the demographics, clinical and laboratory characteristics, management and outcomes of COVID-19 among newborns and infants in the United Arab Emirates (UAE). Clinical and biochemical markers were evaluated for their accuracy in predicting intensive care unit (ICU) transfer and death. Results: A total of 576 COVID-19-positive infants were evaluated with a mean age of 164 days. The mean duration of symptoms was 1.48 days. Fever was present in 36.5% of the cohort, while 44.3% had nasal congestion. Eight infants (of 575; 1.39%) required transfer to the ICU for impending respiratory failure and 2 required invasive ventilation. Symptomatic (fever, nasal congestion) infants were not more likely to be transferred to the ICU (Chi-squared test, P = 0.77). ICU transfer was associated with a higher chance of receiving antibiotics (70.6% vs 35.4%; Chi-squared test, P = 0.003). On multivariate analysis, none of the clinical parameters (age, symptoms, laboratory tests) predicted transfer to the ICU. No deaths were reported during the observation period. Conclusions: Infants with SARS-CoV-2 infection have a benign clinical course with favorable outcomes. Less than 2% require ICU transfer. Clinical vigilance is required as none of the admission parameters predicted ICU transfer.

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Section: Discussionmentioning

confidence: 99%

“…Most studies from neighboring regions extrapolated infant data from a pool of pediatric data and did not dedicate a study characterizing SARS-CoV-2 in infants alone. 23–26…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes of COVID-19 in Newborns and Infants: A Multicenter Experience of 576 Cases

Dhaheri¹,

Dannan²,

Hashim³

et al. 2023

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…Furthermore, high levels of CRP and lactate dehydrogenase were significantly associated with symptomatic children. History of contact with family or household member was reported in the majority of infected patients ( Ennab et al, 2021 ). In Iraq, Salih et al, found that fever was the common symptom detected in children with COVID-19.…”

Section: Childrenmentioning

confidence: 99%

Prognosis of COVID-19 in the middle eastern population, knowns and unknowns

Dandachi

Aljabr

2022

Front. Microbiol.

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Since its emergence in China in 2019, the SARS-CoV-2 virus has affected all countries worldwide. The virus is easily transmitted from one person to another via infected aerosols or contaminated surfaces. Unlike its counterparts, the prognosis of COVID-19 ranges from asymptomatic to critical disease or death. Several factors play a role in determining the severity of the disease in infected patients. Among others, is the pre-existence of an underlying medical condition such as diabetes, cancer, and others. Furthermore, although children are less prone to the severe form of the COVID-19 disease, they require attention due to the report of many atypical presentations of the infection, post-asymptomatic exposure. In the Middle East, little is known about the prognosis of the SARS-CoV-2 infection in high-risk categories, notably patients with diabetes, cancer, and pregnant women. The aim of this review is to summarize the current knowledge about this group of population in the middle eastern region as well as to highlight the gap in the literature. We have found that the majority of the papers were from the Gulf countries. Although, few studies were conducted; high-risk patients appear to have an increased risk of morbidity and mortality from COVID-19 compared to their counterparts. Higher levels of inflammatory markers, C-reactive protein, erythrocyte sedimentation rate, D-dimer, and ferritin levels were also observed. Children are often asymptomatic or present with atypical presentations. More studies should be conducted to determine the clinical biomarkers of COVID-19 in high-risk categories to help in patient risk stratification and management in the middle eastern population.

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Effects of COVID-19 Pandemic on Young Individuals - A Mini Review

Susarla¹,

Eldin

Coelho³

2023

NEMJ

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Background: The COVID-19 pandemic has dominated the last two years of the life of young individuals from every aspect. Medical illness associated with COVID-19 is only one element of the detrimental impact that it has had. The psychological, educational, and social aspects of young individuals have been affected with potentially far-reaching effects. The aim of this review is to determine the negative impact of COVID-19 in each of these areas and inform future practices or policies on the management of young individuals impacted by COVID-19 or future pandemics of this magnitude. Methods: We have collated and analyzed data available on the psychosocial, educational, and social aspects of young individuals in an attempt to understand the negative impact of COVID-19 on this group. Data were collected from an extensive Medline search of relevant articles relating to the effect of COVID-19 on individuals less than eighteen years. Result: Our results show that although young individuals experienced a milder form of COVID-19 in the pandemic, conditions, such as anxiety, depression, and loss of routine, have caused considerable comorbidities in this population. Young individuals have also experienced a greater rise in obesity and a higher incidence of myopia. A key finding of this review showed that children with special needs experienced a lack of continuity of care. Additionally, distant and digital learning presented challenges for children from different backgrounds. Concerns regarding wider issues, such as finance, have also directly impacted young individuals. Vaccination for COVID-19 among children has also raised important ethical issues. Conclusion: COVID-19 has negatively impacted the psychological, physical, and emotional needs of young individuals with potentially far-reaching consequences. A combined psychosocial and clinical approach to tackling the specific needs of young individuals is essential to support the needs and management of individuals affected by the pandemic. The findings of our review recommend measures to include balancing screen time with outdoor activity and encouraging the continued education of children regarding good health practices and vaccination in particular. We hope that this will inform future practices or policies on the management of young individuals impacted by COVID-19 or future pandemics of this magnitude.

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Clinical Characteristics of Children With COVID-19 in the United Arab Emirates: Cross-sectional Multicenter Study

Cited by 8 publications

References 21 publications

Clinical Outcomes of COVID-19 in Newborns and Infants: A Multicenter Experience of 576 Cases

Clinical Outcomes of COVID-19 in Newborns and Infants: A Multicenter Experience of 576 Cases

Prognosis of COVID-19 in the middle eastern population, knowns and unknowns

Effects of COVID-19 Pandemic on Young Individuals - A Mini Review

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