Clinical characteristics of children with Guillain-Barré syndrome and factors associated with disease severity

Luo, Hanyu; Li, Xiujuan; Chen, Min; Wang, Juan; Xie, Lingling; Yao, Zhengxiong; Jiang, Li

doi:10.1016/j.jocn.2021.08.001

Cited by 5 publications

(9 citation statements)

References 32 publications

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“…According to our study, 4%, 50%, 96%, and 94% of GBS patients presented with symptoms of respiratory failure, upper limb paralysis, lower limb paralysis, and inability to walk, respectively. Similar to other studies, limb weakness was the most common presentation 23,24 …”

Section: Discussionsupporting

confidence: 84%

“…Similar to other studies, limb weakness was the most common presentation. 23,24 The mean of PLR, NLR, and MLR in our patients have been 124.2426, 1.9634, and 0.2448, respectively, which are consistent with the study of Kim and colleagues, which reported the average PLR and NLR in fully recovered patients to be 112.7 and 1.38, respectively. 25 Ethemoglu and colleagues reported that NLR in hospitalized, discharged and control participants were 1.51, 1.47, and 1.39, respectively.…”

Section: Covid-19 Pandemicsupporting

confidence: 91%

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The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

Javankiani,

Nasrollahizadeh,

Gharib

et al. 2023

Health Science Reports

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Background and AimsIn the pathophysiology of Guillain–Barre syndrome (GBS), inflammation and immunity are believed to play a key role. The neutrophil‐lymphocyte ratio (NLR), monocyte‐lymphocyte ratio (MLR), and platelet‐lymphocyte ratio (PLR) have been recently identified as potential markers of inflammation or immunity. This study aimed to investigate whether NLR, MLR, and PLR are associated with GBS characteristics in children. We also assessed the impact of the COVID‐19 pandemic on the characteristics of GBS in Iran.MethodsIn this retrospective cross‐sectional study, we reviewed the records of all 150 children diagnosed with GBS in the Children's Medical Center hospital affiliated with Tehran University of Medical Sciences (TUMS) from March 2017 until March 2022. The TUMS research ethics committee approved the study (Ethics code: IR.TUMS.CHMC.REC.1399.125). Patients' data including gender, age, clinical symptoms, laboratory findings, and electrodiagnostic study results were collected and analyzed.ResultsThis study involved 150 children, comprising 93 boys and 57 girls, with an average age of 7.53 ± 3.75 years. The analysis demonstrated that the number of hospitalization days increased with an increase in NLR (p = 0.025). Moreover, patients with abnormal electrodiagnostic study patterns had a higher risk of intensive care unit (ICU) admission (p: 0.027), although according to binary logistic regression, respiratory failure at admission time was the only significant factor increasing the risk of ICU admission (p = 0.035). The study also found that the pandemic has resulted in a shift from acute inflammatory demyelinating polyneuropathy to acute motor axonal neuropathy as the most common EMG‐NCV pattern in our patients (p < 0.001).ConclusionWe found that higher NLR was associated with a longer hospitalization duration and could potentially distinguish between severe and mild cases of GBS. We have also shown that the COVID‐19 pandemic has changed our patients' most frequent electromyography and nerve conduction velocity (EMG‐NCV) patterns.

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Section: Discussionsupporting

confidence: 84%

Section: Covid-19 Pandemicsupporting

confidence: 91%

The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

Javankiani,

Nasrollahizadeh,

Gharib

et al. 2023

Health Science Reports

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“…GBS as a peripheral neuropathy, is regarded to be characterized by decreased tendon reflexes, and normal or hyperactive deep tendon reflexes are rare. However, previous studies [ 36 , 37 , 38 ] showed that 5–12% of patients had normal or hyperactive tendon reflexes. In our study, we found that tendon reflexes were normal in 13 (13.1%) of AIDP, 12 (11.4%) of AMAN, and 4 (3.8%) of AMAN had hyperreflexia on admission.…”

Section: Discussionmentioning

confidence: 96%

Guillain–Barré Syndrome in Northern China: A Retrospective Analysis of 294 Patients from 2015 to 2020

Zhai

Guo

Xue

et al. 2022

JCM

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Objectives: Acute motor axonal neuropathy (AMAN) was first reported to be the main subtype of Guillain–Barré syndrome (GBS) in northern China in the 1990s. About 30 years has passed, and it is unknown whether the disease spectrum has changed over time in northern China. We aimed to study the epidemiological, clinical, and electrophysiological features of GBS in northern China in recent years. Methods: We retrospectively analyzed the medical records of GBS patients admitted to the Second Hospital of Hebei Medical University in northern China from 2015 to 2020. Results: A total of 294 patients with GBS were enrolled, with median age 53 years and 60.5% of participants being male, and a high incidence in summer and autumn. AMAN was still the predominant subtype in northern China (40.1%). The AMAN patients had shorter time to nadir, longer hospitalization time, and a more severe HFGS score at discharge than acute inflammatory demyelinating polyneuropathies (AIDP) (p < 0.05). With SPSS multivariable logistic regression analysis, we found the GBS disability score (at admission), dysphagia, and dysautonomia were independent risk factors for GBS patients requiring MV (p < 0.05). In comparison with other regions, the proportion of AMAN in northern China (40.1%) was higher than in eastern (35%) and southern (19%) China. Conclusions: AMAN is still the predominant subtype in northern China after 30 years, but there have been changes over time in the GBS spectrum since the 1990s. There are regional differences in GBS in China.

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“…Two of the identified studies came from the same centre and the study with the shorter duration of study period was excluded. The relevant data is summarized in Supplementary Table 3 [9][10][11][12][13][25][26][27][28][29][30][31][32].…”

Section: Literature Reviewmentioning

confidence: 99%

“…AMAN was previously thought to be the most prevalent subtype amongst Chinese population and was once called the Chinese paralytic syndrome [8]. However, later studies have shown that AMAN is not only common in east Asia [9][10][11], but also in India [12,13] and Bangladesh [2]. AMSAN resembles AMAN but has an additional sensory component.…”

Section: Introductionmentioning

confidence: 99%

Guillain-Barré syndrome in children – High occurrence of Miller Fisher syndrome in East Asian region

Chiu

Chan²,

Yau³

et al. 2022

Brain and Development

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Clinical characteristics of children with Guillain-Barré syndrome and factors associated with disease severity

Cited by 5 publications

References 32 publications

The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

The characteristics of Guillain–Barre syndrome in children in pre‐COVID‐19 and during the COVID‐19 pandemic: A cross‐sectional study

Guillain–Barré Syndrome in Northern China: A Retrospective Analysis of 294 Patients from 2015 to 2020

Guillain-Barré syndrome in children – High occurrence of Miller Fisher syndrome in East Asian region

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