Clinical characteristics of children with omicron SARS-CoV-2 infection in Changchun, China from march to april 2022: A retrospective study

Li, Yanchun; Ma, Zhenqiang; Zhong, Hua-ying; You, Hailong

doi:10.3389/fped.2022.990944

Cited by 10 publications

(7 citation statements)

References 31 publications

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“…In China, the ght against Omicron has lasted nearly a whole year, and on December 8, 2022, the epidemic prevention and control policy was o cially optimized by releasing the zero-COVID approaches and lifting mandatory quarantine measures. As expected, the sudden arrival of Omicron has fueled a surge in coronavirus-infected cases across China, affecting all age groups, including children [2,3]. In spite of stronger transmission and immune escape abilities, Omicron infection is associated with shorter recovery time and lower fatality rate [4].…”

Section: Introducitonmentioning

confidence: 97%

Impact of Omicron Infection on Childhood Health: The China Long-COVID Study

Zhou,

Li,

et al. 2023

Preprint

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Purpose The aim of this prospective study was to assess the dynamic changes of persisting symptoms among children aged 6–18 years during 1–2 months after the Omicron infection based on the modification of SBQ-LC in Tongzhou cohort, Beijing. Methods This study includes 4 serial surveys performed on January 7–9, January 14–16, January 21–23 and February 12–14, respectively. The prediction of age and survey for eight domains in the Rasch 0-100 linear score was undertaken by generalized additive mixed model. Results Total 1536 children (median age: 13 years, boys: 49.9%) had completed information across 4 surveys. Information on 51 symptoms was collected, with each scored on a 4-point rating scale. Generally, the distribution of age with all domains followed the N-shaped geometry, and that of survey followed the inverse J-shaped geometry. The Rasch linear score hit the lowest level among children aged 6–8 years, and reached the peak among children aged 12–13 years. The scores of all domains sharply declined from the first to the third survey, and remained stable between the third and the fourth survey. At the fourth survey, 95.05% and 51.37% of children still had one or more problems relating to breathing and mental health, respectively, and the percentage of rest six domains was reduced to less than 20%. Conclusions Our findings indicate the multifaceted impact of Omicron infection on childhood health, especially among children aged 12–13 years. Moreover, breathing and mental health related problems still persisted during 1-to-2-month Omicron infection period.

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Section: Introducitonmentioning

confidence: 97%

Impact of Omicron Infection on Childhood Health: The China Long-COVID Study

Zhou,

Li,

et al. 2023

Preprint

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“…During this wave, a surge of hospitalized patients has strained healthcare systems, although mortality rates have been relatively lower [ 5 , 6 ]. Particularly noteworthy is the significant rise in hospitalizations of children infected with the Omicron variant during this period [ 5 , 6 , 9 , 10 ]. While severe illness from COVID-19 is rare in pediatric patients, most cases in children present milder symptoms compared to infected adults, such as fever, cough, rhinorrhea, diarrhea, nausea/vomiting, or an asymptomatic state [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Critically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China

Lin,

Jiang,

Zhang

et al. 2024

BMC Pediatr

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Background SARS-CoV-2 infection is described as asymptomatic, mild, or moderate disease in most children. SARS-CoV-2 infection related death in children and adolescents is rare according to the current reports. COVID-19 cases increased significantly in China during the omicron surge, clinical data regarding pediatric critical patients infected with the omicron variant is limited. In this study, we aim to provide an overview of the clinical characteristics and outcomes of critically ill children admitted to a national children’s medical center in Guangdong Province, China, during the outbreak of the omicron variant infection. Methods We conducted a retrospective study from November 25, 2022, to February 8, 2023, which included 63 critically ill children, under the age of 18, diagnosed with SARS-CoV-2 infection. The patients were referred from medical institutions of Guangdong province. The medical records of these patients were analyzed and summarized. Results The median age of patients was 2 years (Interquartile Range, IQR: 1.0–8.0), sex-ratio (male/female) was 1.52. 12 (19%) patients (age ≥ 3 years) were vaccinated. The median length of hospital stay was 14 days (IQR: 6.5–23) in 63 cases, and duration of fever was 5 days (IQR: 3-8.5), pediatric intensive care unit (PICU) stay was 8 days (IQR 4.0–14.0) in 57 cases. 30 (48%) cases had clear contact history with family members who were infected with SARS-CoV-2. Three children who tested positive for SARS-CoV-2 infection did not show any abnormalities on chest imaging examination. Out of the total patients, 33 (52%) had a bacterial co-infection, with Staphylococcus aureus being the most commonly detected bacterial pathogen. Our cohort exhibited respiratory and nervous system involvement as the primary features. Furthermore, fifty (79%) patients required mechanical ventilation, with a median duration of 7 days (IQR 3.75–13.0). Among these patients, 35 (56%) developed respiratory failure, 16 (25%) patients experienced a deteriorating progression of symptoms and ultimately succumbed to the illness, septic shock was the most common condition among these patients (15 cases), followed by multiple organ failure in 12 cases, and encephalopathy identified in 7 cases. Conclusion We present a case series of critically ill children infected with the SARS-CoV-2 omicron variant. While there is evidence suggesting that Omicron may cause less severe symptoms, it is important to continue striving for measures that can minimize the pathogenic impact of SARS-CoV-2 infection in children.

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“…Omicron rapidly replaced Delta as the dominant variant worldwide since November/December 2021 [ 2 ]. Omicron has shown significantly reduced pathogenicity compared to previous strains [ 3 ], with 90% of infected children experiencing mild symptoms [ 4 ]. The main symptoms include upper respiratory tract infections, fever, sore throat, cough, and wheezing [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Timing of general anesthesia for pediatric patients recovering from COVID-19: a prospective cohort study

Zhao,

Liu,

Zhang

et al. 2024

BMC Anesthesiol

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Objective To explore the timing of general anesthesia for pediatric patients who have recovered from novel coronavirus infection and summarize anesthesia-related complications. Methods We summarized the perioperative management of children under 14 years of age who underwent general anesthesia in our hospital according to national epidemic prevention and control requirements. We compared the incidence of postoperative pulmonary complications within 2 weeks (Group A), 3–4 weeks (Group B), and 5–6 weeks (Group C) after COVID-19 recovery. Results There were differences among the three groups in terms of decreased blood oxygen saturation (< 94%), secretions, and coughing during the PACU period. The risk of low blood oxygen saturation during PACU decreased as the time of COVID-19 recovery extended in the three groups. Compared to Group A, the risk of low blood oxygen saturation was lower in Group B. The presence of respiratory symptoms and a body temperature above 40℃ increased the risk of decreased blood oxygen saturation. The proportion of children aged 11–14 years and children with high fever experiencing decreased blood oxygen saturation during PACU was higher in Groups A and B. Among the three groups, children with respiratory symptoms and longer illness duration had a higher proportion of decreased blood oxygen saturation during PACU. Conclusion Pediatric patients who have recovered from COVID-19 for more than 2 weeks have a lower risk of postoperative complications after general anesthesia. For children with respiratory system symptoms or high fever, there is a higher risk of transient blood oxygen saturation decrease during PACU. For older children, those with high fever, respiratory system symptoms, or longer illness duration, it is recommended to appropriately extend the time from COVID-19 recovery to surgery.

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Clinical characteristics of children with omicron SARS-CoV-2 infection in Changchun, China from march to april 2022: A retrospective study

Cited by 10 publications

References 31 publications

Impact of Omicron Infection on Childhood Health: The China Long-COVID Study

Impact of Omicron Infection on Childhood Health: The China Long-COVID Study

Critically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China

Timing of general anesthesia for pediatric patients recovering from COVID-19: a prospective cohort study

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