Clinical characteristics of bladder cancer in patients with spinal cord injury: the experience from a single centre

Böthig, Ralf; Kurze, Ines; Fiebag, Kai; Kaufmann, Albert; Schöps, Wolfgang; Kadhum, Thura; Zellner, Michael; Golka, Klaus

doi:10.1007/s11255-017-1570-6

Cited by 37 publications

(21 citation statements)

References 51 publications

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“…The PRISMA flow diagram of the literature search and results is shown in Figure . After screening 637 abstracts, 15 studies published between 1981 and 2017 were included in a narrative synthesis (Tables –): 13 retrospective studies and 2 prospective studies.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: A systematic review

Ismail

Karsenty

Chartier‐Kastler

et al. 2017

Neurourology and Urodynamics

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Section: Resultsmentioning

confidence: 99%

“…However, this practice remains controversial due to lack of sensitivity and specificity . Moreover, cystoscopies in patients with a SCI above T6 may trigger autonomic dysreflexias and therefore should be performed by specialised urologists or under general anaesthesia …”

Section: Discussionmentioning

confidence: 99%

Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: A systematic review

Ismail

Karsenty

Chartier‐Kastler

et al. 2017

Neurourology and Urodynamics

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“…The urea concentration in urine is 20–100 times higher than that in blood in humans [ 20 , 21 ]. Interestingly, the risk of UBC for people with spinal cord injuries is 16–28 times higher than that for the general population [ 22 , 23 ], underscoring the important role of endogenous factors, including urea, in the bladder tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

SLC14A1 (UT-B) gene rearrangement in urothelial carcinoma of the bladder: a case report

Guo

Niu

et al. 2020

Diagn Pathol

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Background Bladder cancer (BC) is a common and deadly disease. Over the past decade, a number of genetic alterations have been reported in BC. Bladder urothelium expresses abundant urea transporter UT-B encoded by Slc14a1 gene at 18q12.3 locus, which plays an important role in preventing high concentrated urea-caused cell injury. Early genome-wide association studies (GWAS) showed that UT-B gene mutations are genetically linked to the urothelial bladder carcinoma (UBC). In this study, we examined whether Slc 14a1 gene has been changed in UBC, which has never been reported. Case presentation A 59-year-old male was admitted to a hospital with the complaint of gross hematuria for 6 days. Ultrasonography revealed a size of 2.8 × 1.7 cm mass lesion located on the rear wall and dome of the bladder. In cystoscopic examination, papillary tumoral lesions 3.0-cm in total diameter were seen on the left wall of the bladder and 2 cm to the left ureteric orifice. Transurethral resection of bladder tumor (TURBT) was performed. Histology showed high-grade non-muscle invasive UBC. Immunostaining was negative for Syn, CK7, CK20, Villin, and positive for HER2, BRCA1, GATA3. Using a fluorescence in situ hybridization (FISH), Slc14a1 gene rearrangement was identified by a pair of break-apart DNA probes. Conclusions We for the first time report a patient diagnosed with urothelial carcinoma accompanied with split Slc14a1 gene abnormality, a crucial gene in bladder.

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“…Mesane kanseri güncel epidemiyolojik bulgulara göre tüm dünyada en sık görülen kanserler arasında dokuzuncu sıradır (1). Mesane kanseri gelişiminde genetik yatkınlığın yanısıra sigara ve diğer tütün ürünlerinin kullanımı, içme suyundan yüksek arsenik maruziyeti, aromatik aminlere maruziyet, erkek cinsiyet ve omurilik hasarı sonrası nörojenik mesane oluşumu da suçlanmıştır (2,3).…”

Section: Introductionunclassified

Outcomes of Adjuvant Intravesical Mitomycin-C Treatment in Non-Muscle Invaziv High-Grade Bladder Cancer: Singe center experience

Cakici¹,

Hamidi²

2019

Acta Oncol Tur.

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Kas invazyonu yapmamış yüksek dereceli mesane kanserlerinin tedavisinde adjuvan intravesikal mitomisin-c tedavisinin sonuçlarını bildirmek YÖNTEM ve GEREÇLER: Kliniğimizde Ocak 2012 ile Aralık 2018 tarihleri arasında mesane kanseri nedeniyle endoskopik tedavi uygulanmış hastaların patolojileri geriye dönük olarak değerlendirildi. Kas invazyonu yapmamış ve yüksek dereceli ürotelyal tümörü olan hastaların hastane başvuru kayıtları incelenerek adjuvan intravezikal mitomisin-c tedavisi almış olan hastaların bilgileri çalışmaya dahil edildi. Hastaların demografik verileri, sistoskopi bulguları, patolojik bulgular ve poliklinik başvuru kayıtları incelenerek analize dahil edildi. BULGULAR: Toplam 54 hasta istatistiksel analize dahil edildi. Bu hastalar içinde 50 hastada patolojik evre T1 saptanırken 4 hastada patolojik evre Ta saptandı. Hiçbir hastada karsinoma in situ varlığı tespit edilmedi. Ortalama tümör boyutu 1.4 cm olarak bulundu. Adjuvan tedavi başlanması için endoskopik tedavi sonrasındaki bekleme süresi ortalama 2 (1-4) haftaydı. Ortalama takip süresi 21 ay olarak saptandı. Takiplerde evre ilerlemesi hastaların 14'ünde (%26) görülürken yüksek dereceli nüks 22 hastada (%41), düşük dereceli nüks 4 hastada (%7) görüldü. Nüks görülen 22 hastanın 6'sında aynı zamanda ilerleme de görüldü. TARTIŞMA ve SONUÇ: Kas invazyonu yapmamış yüksek dereceli mesane kanseri daha ileri evreye ilerleme ve nüks ihtimali yüksek bir kanser türüdür. Kılavuzlarda ilk önerilen adjuvan tedavi seçeneği intravezikal Bacillus-Calmette-Guérin suşu uygulamasıdır. Bizim sonuçlarımıza göre mitomycin-c tedavisi de adjuvan intravezikal tedavi için başarılı bir alternatif olarak değerlendirilebilir.

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Clinical characteristics of bladder cancer in patients with spinal cord injury: the experience from a single centre

Abstract: The significantly younger age at onset and the frequency of invasive tumours at diagnosis indicate that spinal cord injury influences bladder cancer risk and prognosis as well. Early detection of bladder cancer in patients with spinal cord injury remains a challenge.

Cited by 37 publications

References 51 publications

Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: A systematic review

Prevalence, management, and prognosis of bladder cancer in patients with neurogenic bladder: A systematic review

SLC14A1 (UT-B) gene rearrangement in urothelial carcinoma of the bladder: a case report

Outcomes of Adjuvant Intravesical Mitomycin-C Treatment in Non-Muscle Invaziv High-Grade Bladder Cancer: Singe center experience

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