Clinical characteristics of and outcomes for patients with COVID-19 and comorbid lung diseases primarily hospitalized in a conventional pulmonology unit: A retrospective study

Riou, Marianne; Marcot, Christophe; Canuet, Matthieu; Renaud-Picard, B.; Chatron, Eva; Porzio, Michele; Degot, T.; Hirschi, Sandrine; Metz-Favre, C.; Kassegne, L.; Ederlé, Carole; Khayath, N.; Labani, Aïssam; Leyendecker, Pierre; Blay, F. De; Kessler, Romain

doi:10.1016/j.resmer.2020.100801

Cited by 12 publications

(10 citation statements)

References 44 publications

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“…TBEV seroreactive patients from Serbia are considerably younger (35 years (95% CI: 18–50.6) when compared to TBE patients from central Europe, where the average age was reported to be 50 years (range 0–88) [ 34 ]. The probable reason for this difference is the bias in our study caused by targeted enrollment of persons who recovered from viral CNS infections as persons of older ages have higher possibilities for the development of sequelae and lethal outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…It should also be noted that although we found anti-TBEV antibodies in enrolled convalescents, we do not know the specific etiology of their viral CNS infection, as TBEV exposure could happen even after their hospital discharge. On the other hand, the study from central Europe evaluated patients with confirmed TBE diagnosis and inclusion was not dependent on disease outcome (survived/non-survived) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis

et al. 2022

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The tick-borne encephalitis virus (TBEV) causes a life-threatening disease named Tick-borne encephalitis (TBE). The clinical symptoms associated with TBE range from non-specific to severe inflammation of the central nervous system and are very similar to the clinical presentation of other viral meningitis/encephalitis. In consequence, TBE is often misclassified by clinical physicians, mainly in the non-identified high-risk areas where none or only a few TBE cases have been reported. Considering this situation, we hypothesized that among persons from northern Serbia who recovered from viral meningitis or encephalitis, there would be evidence of TBEV infection. To test this hypothesis, in this observational study, we evaluated the seroreactivity against TBEV antigens in patients from northern Serbia who were hospitalized due to viral meningitis and/or viral encephalitis of unknown etiology. Three cases of seroreactivity to TBEV antigens were discovered among convalescent patients who recovered from viral meningitis and/or encephalitis and accepted to participate in the study (n = 15). The clinical and laboratory findings of these patients overlap with that of seronegative convalescent patients. Although TBE has been a notifiable disease in Serbia since 2004, there is no active TBE surveillance program for the serologic or molecular screening of TBEV infection in humans in the country. This study highlights the necessity to increase the awareness of TBE among physicians and perform active and systematic screening of TBEV antibodies among patients with viral meningitis and/or encephalitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis

et al. 2022

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“…Nevertheless, Körper et al did not report the link of body weight with nAbs level in CCP donors [ 22 ]. Additionally, no correlation with anti-SARS-CoV-2 Abs level was found in the persons with chronic liver disease, chronic lung disease or diabetes [ 52 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

Grujic

Bujandric

Budakov-Obradović

et al. 2021

IJERPH

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Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals (n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals (p = 0.034), older age groups (p < 0.001), existence of hypertension (p = 0.008), and severe COVID-19 (p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity.

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“…Additionally, as expected, pre‐existing pulmonary disease increases mortality and morbidity rates after COVID‐19 infection as shown herein and by others. 41 , 42 , 43 Furthermore, male sex was an independent factor associated with increased 30‐day mortality rates. 44 , 45 We also found that male sex was positively associated with all‐cause mortality and overall COVID‐19 infection.…”

Section: Discussionmentioning

confidence: 91%

COVID‐19 infection and its consequences among surgical oncology patients: A systematic analysis, meta‐analysis and meta‐regression

Kamal

Baudo

Shmushkevich

et al. 2022

Journal of Surgical Oncology

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We conducted this meta‐analysis to address the outcomes in cancer patients after oncologic surgery during COVID‐19 pandemic. The primary endpoint was the COVID‐19–related mortality rate. Higher body mass index was significantly and negatively associated with higher all‐cause mortality and in‐hospital COVID‐19 infection rates. Male sex, preoperative respiratory disease, and smoking history were positively and significantly associated with increased all‐cause mortality rates. Furthermore, male sex was positively and significantly associated with the COVID‐19 infection rate.

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Clinical characteristics of and outcomes for patients with COVID-19 and comorbid lung diseases primarily hospitalized in a conventional pulmonology unit: A retrospective study

Cited by 12 publications

References 44 publications

Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis

Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

COVID‐19 infection and its consequences among surgical oncology patients: A systematic analysis, meta‐analysis and meta‐regression

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