Clinical characteristics of allergic rhinitis patients in 13 metropolitan cities of China

Zheng, Ming; Wang, Xiangdong; Wang, Meng; She, Wenyu; Cheng, Long; Lu, Mei‐Ping; Xing, Zhimin; Ma, Furong; Zhu, Li; Chen, Lei; Lin, Xiaoping; Jiang, Xuejun; Zhu, Dongdong; Xu, Geng; Wen, Wang; Kong, Weijia; Chen, Jianjun; Tao, Zezhang; Xu, Yu; Wang, Dehui; Liu, Shixi; Wang, Shenqing; Jiang, Weihong; Sun, Jingwu; Zhao, Changqing; Suo, Limin; Zhang, Hua; Zhang, Luo

doi:10.1111/all.14561

Cited by 23 publications

(16 citation statements)

References 6 publications

(6 reference statements)

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“…One of the first case series published in China on 40 COVID-19 inpatients reported that the main symptom was dyspnoea (55%) while diarrhoea was described in 3% of cases only; the median age of subjects was 49 years [ 1 ]. Other Chinese studies reported different percentage of gastrointestinal symptoms [ 20 , 21 ]: Zhang et al reported fever (91%), cough (75%), fatigue (75%) and gastrointestinal symptoms (39%) as the most common clinical manifestations in 140 hospitalized COVID -19 patients while Wang et al found a gastrointestinal onset rate of 10.1% in a group of 138 hospitalized patients with a median age of 56 years. Cheung et al, in their meta-analysis of 60 studies involving 4,243 COVID-19 patients from six countries, found digestive symptoms in 17.6% of the patients with specific rates of anorexia (26.8%), diarrhoea (12.5%), nausea/vomiting (10.2%) and abdominal pain/discomfort (9.2%).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 inpatients with gastrointestinal onset: sex and care needs’ differences in the district of Ferrara, Italy

et al. 2021

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Background COVID-19 is characterized by interstitial pneumonia, but a presentation of the disease with digestive symptoms only may occur. This work was aimed at evaluating: (1) the prevalence of presentation with digestive symptoms only in our cohort of COVID-19 inpatients; (2) differences between patients with and without gastrointestinal onset; (3) differences among males and females with gastrointestinal presentation; (4) outcomes of the groups of subjects with and without gastrointestinal onset. Method We retrospectively divided the patients hospitalized with COVID-19 into two groups: (1) the one with digestive symptoms (DSG) and (2) the other without digestive symptoms (NDSG). We compared the subjects of DSG with those of NDSG and males with females in the DSG group only, in terms of demographics (age, sex), inflammation and organ damage indexes, length of stay, in-hospital and 100-day mortality. Results The prevalence of gastrointestinal symptoms at presentation was 12.5%. The DSG group showed a prevalence of females, and these tended to a shorter hospital stay; DSG patients were younger and with a higher load of comorbidities, but no differences concerning inflammation and organ damage indexes, need for intensification of care, in-hospital and 100-day mortality were detected. Among DSG patients, males were younger than females, more comorbid, with higher serum CRP and showed a longer length of hospital stay. Survival functions of DSG patients, in general, are more favourable than those of NDSG if adjusted for sex, age and comorbidities. Conclusions (1) The prevalence of gastrointestinal presentation among hospitalized COVID-19 patients was 12.5%; (2) DSG patients were on average younger, more comorbid and with a prevalence of females, with a shorter hospital stay; (3) in the DSG group, males had a higher Charlson Comorbidity Score and needed a longer hospital stay; (4) DSG subjects seem to survive longer than those of the NDSG group.

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Section: Discussionmentioning

confidence: 99%

COVID-19 inpatients with gastrointestinal onset: sex and care needs’ differences in the district of Ferrara, Italy

et al. 2021

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“…This “China Issue” of Allergy highlights the latest progress and contributions by Chinese scholars in improving our understanding of the COVID‐19 epidemiology and pathogenesis, and in the diagnosis of asthma and allergic diseases during the pandemic. Zheng et al reported the clinical characteristics of allergic rhinitis (AR) patients in 13 metropolitan cities of China and outlined the regional differences in the pathogenesis of AR in China 1 . Shi et al also showed that the production and release of cold‐inducible RNA‐binding protein (CIRP) was upregulated in the nasal epithelial cells and macrophages, contributing to edema formation in both eosinophilic and non‐eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) by inducing matrix metalloproteinases (MMPs) and vascular endothelial growth factor A (VEGF‐A) production in these cells 2 .…”

Section: Figurementioning

confidence: 99%

The inspirational journey of Chinese scholars in the field of allergy

Zhang

Akdiş

2021

Allergy

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“…Allergic rhinitis (AR) has developed into a global concern and affected 10% to 40% of the world population 1 . Numerous studies have indicated that the increased incidence of AR is associated with social stress and western lifestyle 2,3 .…”

Section: Introductionmentioning

confidence: 99%

“…Allergic rhinitis (AR) has developed into a global concern and affected 10% to 40% of the world population. 1 Numerous studies have indicated that the increased incidence of AR is associated with social stress and western lifestyle. 2 , 3 The misalignment between the endogenous biological clock and the individual's daily activities in modern society, such as artificial light during the long night, shift work, or travel across time zones, might influence and alter the process of allergy.…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythm disruption exacerbates Th2‐like immune response in murine allergic airway inflammation

Cheng

Xue

et al. 2021

Int Forum Allergy Rhinol

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Background Chronic jet lag (CJL)‐induced circadian rhythm disruption (CRD) is positively correlated with an increased risk of allergic diseases. However, little is known about the mechanism involved in allergic rhinitis (AR). Methods Aberrant light/dark cycles‐induced CRD mice were randomly divided into negative control (NC) group, AR group, CRD+NC group, and CRD+AR group (n = 8/group). After ovalbumin (OVA) challenge, nasal symptom scores were recorded. The expression of Occludin and ZO‐1 in both nasal mucosa and lung tissues was detected by reverse transcription–quantitative polymerase chain reaction (RT‐PCR) and immunohistochemical staining. The level of OVA–specific immunoglobulin E (sIgE) and T‐helper (Th)‐related cytokines in the plasma was measured by enzyme‐linked immunosorbent assay (ELISA), and the proportion of Th1, Th2, Th17, and regulatory T cell (Treg) in splenocytes was evaluated by flow cytometry. Results The nasal symptom score in the CRD+AR group was significantly higher than those in the AR group with respect to eosinophil infiltration, mast cell degranulation, and goblet cell hyperplasia. The expression of ZO‐1 and Occludin in the nasal mucosa and lung tissues in the CRD+AR group were significantly lower than those in the AR group. Furthermore, Th2 and Th17 cell counts from splenocytes and OVA‐sIgE, interleukin 4 (IL‐4), IL‐6, IL‐13, and IL‐17A levels in plasma were significantly increased in the CRD+AR group than in the AR group, whereas Th1 and Treg cell count and interferon γ (IFN‐γ) level were significantly decreased in the CRD+AR group. Conclusion CRD experimentally mimicked CJL in human activities, could exacerbate local and systemic allergic reactions in AR mice, partially through decreasing Occludin and ZO‐1 level in the respiratory mucosa and increasing Th2‐like immune response in splenocytes.

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Clinical characteristics of allergic rhinitis patients in 13 metropolitan cities of China

Cited by 23 publications

References 6 publications

COVID-19 inpatients with gastrointestinal onset: sex and care needs’ differences in the district of Ferrara, Italy

COVID-19 inpatients with gastrointestinal onset: sex and care needs’ differences in the district of Ferrara, Italy

The inspirational journey of Chinese scholars in the field of allergy

Circadian rhythm disruption exacerbates Th2‐like immune response in murine allergic airway inflammation

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