Clinical characteristics of adult patients with influenza-like illness hospitalized in general ward during Influenza A H1N1 pandemic 2009/2010

Pečavar, Blaž; Nadrah, Kristina; Papst, Lea; Čeč, V.; Kotar, Tadeja; Matičič, Mojca; Meglic̆-Volkar, Jelka; Vidmar, Ludvik; Beović, Bojana

doi:10.1007/s00508-011-0054-4

Cited by 6 publications

(8 citation statements)

References 15 publications

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“…This rate is remarkably increased compared to the general population with ILI, where 36% of patients in a pediatric and 34% in an adult emergency room were proven positive during the pandemic [11], [12]. Pecavar et al used a similar study period and case definition of ILI compared to Colombo's data in italian CF patients [11], [41]. Although local differences, like a higher amount of circulating virus in the Italian centers, is a possible reason for the difference, these data suggest that CF patients may have an increased susceptibility to the Influenza A(H1N1)pdm09 virus, at least during the pandemic period.…”

Section: Discussionmentioning

confidence: 95%

“…However, Colombo et al specifically referred to CF patients with ILI and 68/127 (53%) patients were tested positive for Influenza A(H1N1)pdm09 [41]. This rate is remarkably increased compared to the general population with ILI, where 36% of patients in a pediatric and 34% in an adult emergency room were proven positive during the pandemic [11], [12]. Pecavar et al used a similar study period and case definition of ILI compared to Colombo's data in italian CF patients [11], [41].…”

Section: Discussionmentioning

confidence: 99%

“…Incidence rates of Influenza A(H1N1)pdm09 in adults and children with influenza-like illnesses (ILI) were reported to be 33% and 36%, respectively during the pandemic [11] , [12] . Contrary to expectations during the pandemic, Influenza A(H1N1)pdm09 caused only relatively mild disease in the general population.…”

Section: Introductionmentioning

confidence: 99%

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Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Renk

Regamey²,

Hartl

2014

PLoS ONE

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BackgroundTo systematically assess the literature published on the clinical impact of Influenza A(H1N1)pdm09 on cystic fibrosis (CF) patients.MethodsAn online search in PUBMED database was conducted. Original articles on CF patients with Influenza A(H1N1)pdm09 infection were included. We analyzed incidence, symptoms, clinical course and treatment.ResultsFour surveys with a total of 202 CF patients infected by Influenza A(H1N1)pdm09 were included. The meta-analysis showed that hospitalisation rates were higher in CF patients compared to the general population. While general disease symptoms were comparable, the clinical course was more severe and case fatality rate (CFR) was higher in CF patients compared to asthmatics and the general population.ConclusionsEvidence so far suggests that CF patients infected with Influenza A(H1N1)pdm09 show increased morbidity and a higher CFR compared to patients with other chronic respiratory diseases and healthy controls. Particularly, CF patients with advanced stage disease seem to be more susceptible to severe lung disease. Accordingly, early antiviral and antibiotic treatment strategies are essential in CF patients. Preventive measures, including vaccination as well as hygiene measures during the influenza season, should be reinforced and improved in CF patients.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Renk

Regamey²,

Hartl

2014

PLoS ONE

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“…Asthma is the most common underlying disease in patients with influenza admitted to healthcare facilities, both in adults (7.6%‐46%) and in children (8.3%‐42%). Children with asthma accounted for a significantly larger proportion of those hospitalized with pandemic H1N1 than with seasonal influenza .…”

Section: Global Burden Of Influenza In Patients With Asthmamentioning

confidence: 99%

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

Schwarze

Openshaw

Jha

et al. 2018

Allergy

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To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma.

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“…Studies marked in bold used high-sensitivity assays. Study Study population Cardiac troponin assay and relative cut-off Diagnosis of influenza Results Greaves et al., 2003 [ 9 ] 152 patients with Influenza (mean age, 39 years; 49% women) CS-cTnT (<10 ng/L) and CS-cTnI (<100 ng/L) Hemagglutination inhibition assay No patient displayed elevation of either cTn above the URL Ison et al., 2005 [ 10 ] 30 patients with Influenza (mean age, 21 years; 70% women) CS-cTnI (<50 ng/L) Lateral-flow immunoassay No patient displayed elevation of either cTn above the URL Brown et al., 2011 [ 12 ] 48 patients with Influenza A H1N1 virus infection (mean age, 41 years; 70% women) CS-cTnI (400 ng/L) rRT-PCR cTnI values 4-fold higher in patients with acute respiratory distress syndrome Pečavar et al., 2011 [ 11 ] 196 patients with influenza-like illness, 66 of whom (33.7%) positive for Influenza A H1N1 (age range, 17–100 years; 49% women) Unspecified rRT-PCR cTn values 11% higher in patients with Influenza A H1N1 infection Chacko et al., 2012 [ 13 ] 37 patients with complications of Influenza A H1N1 virus infection (mean age, 39 ± 13 years; 68% women) CS-cTnI (<1500 ng/L) rRT-PCR cTn values exceeding the diagnostic cut-off in 46% of patients and associated with 9-dolf higher risk of death Song et al., 2012 [ 14 ] 71 patients with Influenza A H1N1 virus infection (age range, 29–84 years; 56% women) CS-cTnI (unspecified cut-off) Unspecified cTn values similar in patients with or without cardiovascular complications Fagnoul et al. 2013 [ 15 ] 39 patients with Influenza A H1N1 virus infection (mean age, 48 ± 17 years; 52% women) HS-cTnI (unspecified cut-off) rRT-PCR cTn values increase in parallel with the severity of cardiac dysfunction Han et al., 2015 [ 16 ] 40 patients with Influenza A H7N9 infection (60 ± 15 years; 45 women) Unspecified cTnI assay (<13 ng/L) rRT-PCR cTn values higher during infection and also higher in patients ...…”

Section: Evidence From Clinical Studiesmentioning

confidence: 99%

Cardiac troponin elevation in patients with influenza virus infections

Lippi

Sanchís-Gomar

2021

Biomedical Journal

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The association between acute infections and cardiac injury, including myocarditis and acute myocardial infarction, is now well established. We have performed a systematic literature review for analyzing the results of epidemiological studies that measured cardiac troponins (cTn) in patients with Influenza virus infections. Overall, 14 articles were finally identified and analyzed. Taken together, the results of the scientific literature suggest that cTn elevation is a relatively rare phenomenon in patients with Influenza virus infection, with frequency generally comprised between 0 and 33%, more likely in elderly patients with significant comorbidities. In patients with modest cTn elevations, this phenomenon is apparently self-limited, transient and reversible, and especially involves patients with Influenza A (especially H1N1). In the minority of patients exhibiting an abrupt appearance of cardiovascular symptoms and concomitant elevation of cTn values, the relative increase of this biomarker reflects the presence of an underlying cardiac injury, that can be either myocarditis or an acute ischemic episode. Enhanced cTn values can also be more frequently observed in Influenza patients with complicated disease, in those developing acute respiratory distress syndrome and cardiac dysfunction, as well as in those at higher risk of death. cTn measurement shall be considered a valuable option in all patients developing acute cardiovascular symptoms during Influenza virus infections, as well as in those bearing cardiac or extra-cardiac comorbidities who bear a higher risk of complications.

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Clinical characteristics of adult patients with influenza-like illness hospitalized in general ward during Influenza A H1N1 pandemic 2009/2010

Cited by 6 publications

References 15 publications

Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Influenza A(H1N1)pdm09 and Cystic Fibrosis Lung Disease: A Systematic Meta-Analysis

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

Cardiac troponin elevation in patients with influenza virus infections

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