Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland

Takato, Tsuyoshi; Kawata, Ryo; Noro, Keiki; Higashino, Masaaki; Nishikawa, Shuji; Haginomori, Shin‐Ichi; Kurisu, Yoshitaka; Kuwabara, Hiroko; Hirose, Yoshinobu

doi:10.1007/s00405-019-05604-4

Cited by 21 publications

(21 citation statements)

References 15 publications

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“…2 Additionally, SC arises in the minor salivary glands more frequently than ACC, and some authors have suggested that most previously-diagnosed ACC of the minor salivary glands may in fact represent SC. 2,15 In comparison to ACC, studies suggest that SC tends to present with a significantly higher T stage, 5 concordant with a trend towards worse disease free survival (DFS). 4 In one study of SC, 22% of patients undergoing neck dissection were found to have regional lymph node involvement, three patients had a local recurrence, and one patient died from metastatic disease-demonstrating that SC may be more aggressive than ACC.…”

Section: Discussionmentioning

confidence: 96%

“…12 The literature is rich with histologic comparisons of ACC and SC, as they closely resemble one another. 5,15 In fact, since the recognition of SC in 2010, 11 pathologists have re-classified many cases of previously diagnosed ACC as SC. 3,16 Globular PAS staining (indicative of mucin production) differentiates SC from ACC, in which staining is more granular.…”

Section: Discussionmentioning

confidence: 99%

“…2 The ETV6-NTRK3 (t(12;15)(p13;25)) fusion gene (shared with breast secretory carcinoma) has proven virtually pathognomonic for SC, with its prevalence estimated between 95% and 98%. [2][3][4] Although SC and ACC are both generally low-grade in clinicopathologic behavior with relatively favorable prognosis, 5 high-grade cases of SC have been reported, and some small studies have suggested that SC's have higher rates of metastasis and regional lymph node involvement than ACC. 4 Since the first report of SC, the disease has been increasingly recognized in the literature and in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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A case of metachronous bilateral secretory carcinoma

et al. 2021

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Secretory carcinoma (SC) was first recognized as a distinct salivary malignancy in 2010. In the nine years since its recognition, there have been multiple reports of SC of the major and minor salivary glands, as well one case of tongue base involvement. Here we present the first reported case of bilateral SC. The first tumor, diagnosed before the recognition of SC, was classified as mucoepidermoid carcinoma. After the contralateral parotid tumor was diagnosed as SC in 2016, the two histologies were compared, and the mucoepidermoid carcinoma was reclassified as SC. In this report, we describe our patient’s clinical course and review the SC literature, with a focus on pathologic diagnosis and clinical prognosis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case of metachronous bilateral secretory carcinoma

et al. 2021

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“…Most MASC lesions are comprised of multiple cell types, but a few tumor cells are rich in cytoplasm, vesicles, or vacuoles. In contrast, no MASC cells contain zymogen granules, which is a typical characteristic of AciCC[ 17 ]. A certain number of tumor cells appear transparent due to the presence of mucous components as the lumen, microcapsule, and large capsules are filled with eosinophilic homogeneous or vesicular secretions[ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Parotid mammary analogue secretory carcinoma: A case report and review of literature

Min

Tao

et al. 2021

WJCC

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BACKGROUND Mammary analogue secretory carcinoma (MASC) is a rare low-grade malignant salivary gland tumor. The morphological and immunohistochemical features of MASC closely resemble those of breast secretory carcinoma. The key characteristics of the lesion are a lack of pain and slow growth. There is no obvious specificity in the clinical manifestations and imaging features. The diagnosis of the disease mainly depends on the detection of the MASC-specific ETV6-NTRK3 fusion gene. CASE SUMMARY This report describes a rare case of a 32-year-old male patient who presented with a gradually growing lesion that was initially diagnosed as breast-like secretory carcinoma of the right parotid gland. Imaging and histological investigations were used to overcome the diagnostic difficulties. The lesion was managed with right parotidectomy, facial nerve preservation, biological patch implantation to restore the resulting defect, and postoperative radiotherapy. On postoperative follow-up, the patient reported a mild facial deformity with no complications, signs of facial paralysis, or Frey’s syndrome. CONCLUSION The imaging and histological diagnostic challenges for MASC are discussed.

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“…In addition to breast, secretory cancer can also occur in other organs which containing secretory glands, such as parotid gland, salivary gland, sweat gland, lacrimal gland and thyroid [12][13][14][15][16][17]. Secretory carcinoma occurs in other organs shows the same combinative structures of cribriform patterns, solid patterns, and microcystic patterns, and extracellular secretion positive for Alcian blue or PAS.…”

Section: Discussionmentioning

confidence: 99%

Secretory Carcinoma of the Breast With Multiple Distant Metastases in Brain and Unfavorable Prognosis: a Case Report and Literature Review

Tang

Zhong

Jiang

et al. 2021

Preprint

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Background: Secretory carcinoma of the breast is one of the rarest entities accounting for less than 0.15% of all infiltrating breast carcinomas. It has characteristic histopathological and molecular features and more favorable prognosis. In this case report, we describe a local advanced secretory carcinoma of the breast with chemo-resisted for neoadjuvant chemotherapy and unfavorable prognosis.Case Presentation: A hard, painless and palpably bossed mass about 12 cm in diameter occupied most of the left breast of a 39-year-old woman and fixation to the overlying skin. Breast ultrasonography and magnetic resonance imaging (MRI) scan gave the same grading as BI-RADS IV. A needle biopsy was performed and pathological diagnosis was secretory carcinoma. Neoadjuvant chemotherapy (NAC) was then performed, after which ultrasonography and MRI scan revealed the tumor was partial response for EC therapy while progressive disease after the DC therapy. The tumor showed chemo-resisted for neoadjuvant chemotherapy. Left breast mastectomy and axillary lymphadenectomy were subsequently performed. Tumor cells were triple-negative and positive for S-100 and periodic acid-Schiff (PAS) staining. Fluorescence in-situ hybridization (FISH) analysis indicated the fusion arrangement of ETV6-NTRK3 gene. The patient underwent multiple distant metastases in brain, and died of these metastases 19 months after initial diagnosis.Conclusion: Secretory carcinomas of breast have been described as a low-grade histologic subtype with a favorable prognosis. This case showed chemo-resisted for neoadjuvant chemotherapy, multiple distant metastases, and final an unfavorable prognosis. Further research is needed to better understanding of its behavior and treatment of this rare tumor.

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Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland

Cited by 21 publications

References 15 publications

A case of metachronous bilateral secretory carcinoma

A case of metachronous bilateral secretory carcinoma

Parotid mammary analogue secretory carcinoma: A case report and review of literature

Secretory Carcinoma of the Breast With Multiple Distant Metastases in Brain and Unfavorable Prognosis: a Case Report and Literature Review

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