Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China

Abstract

This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. Methods: The clinical records, laboratory findings and radiological assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. Results: The age and underlying diseases (hypertension, diabetes, etc.) were the most important risk factors for death of COVID-19 pneumonia. Bacterial infections may play an important role in promoting the death of patients. Malnutrition was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT, CRP, cTnI, D-dimer, LDH and lactate levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts. Conclusions: The clinical characteristics of 25 death cases with COVID-19 we summarized, which would be helpful to identify critically ill patients of COVID-19 early and reduce their mortality.

Etiology and Antimicrobial Resistance of Secondary Bacterial Infections in Patients Hospitalized With COVID-19 in Wuhan, China: A Retrospective Analysis

“…Respiratory failure or multiple organ failure is the direct cause of death in patients with COVID-19, and SBIs play an important role in this process [16]. Among the 1495 patients with COVID-19, the incidence of SBIs was 6.8%.…”

Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands

“…D-dimer has a very high sensitivity for thrombotic disease, but its specificity is poor. Various studies in patients with COVID-19 have consistently shown a very strong association between increased D-dimer levels and severe disease/poor prognosis (Table 1) (7,11,(13)(14)(15)(16)(17).…”

Blood Biomarkers Dynamic Detection, Especially Eosinophils has Certain Value in the Clinical Diagnosis, Severity Classification and Prognosis Judgment of COVID-19

“…reported similar ndings, indicating the potential critical condition and serious disturbance of internal environment in those severe infected cases [15]. Li et al found that some death cases of COVID-19 have superimposed bacterial pneumonia [16]. Bacterial infection leads to signi cant increased leucocyte count and neutrophil count.…”