Clinical Characteristics of 20,662 Patients with COVID-19 in mainland China: A Systemic Review and Meta-analysis

Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic and has been widely reported; however, a comprehensive systemic review and meta-analysis has not been conducted. We systematically investigated the clinical characteristics of COVID-19 in mainland China to guide diagnosis and treatment. We searched the PubMed, Embase, Scopus, Web of Science, Cochrane Library, bioRxiv, medRxiv, and SSRN databases for studies related to COVID-19 published or preprinted in English or Chinese from January 1 to March 15, 2020. Clinical studies on COVID-19 performed in mainland China were included. We collected primary outcomes including signs and symptoms, chest CT imaging, laboratory tests, and treatments. Study selection, data extraction, and risk of bias assessment were performed by two independent reviewers.Qualitative and quantitative synthesis was conducted, and random-effects models were applied to pooled estimates. This study is registered with PROSPERO (number CRD42020171606). Of the 3624 records identified, 147 studies (20,662 patients) were analyzed. The mean age of patients with COVID-19 was 49.40 years, 53.45% were male, and 38.52% had at least one comorbidity. Fever and cough were the most common symptoms, followed by fatigue, expectoration, and shortness of breath. Most patients with COVID-19 had abnormal chest CT findings with ground glass opacity (70.70%) or consolidation (29.91%). Laboratory findings shown lymphopenia, increased lactate dehydrogenase, increased infection-related indicators, and fibrinolytic hyperactivity. Antiviral therapy, antibiotic therapy, and corticosteroids were administered to 89.75%, 79.13%, and 35.64% of patients, respectively. Most All rights reserved. No reuse allowed without permission.

Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis

“…When compared with adults, most pediatric patients presented with mild or moderate clinical syndromes, and only a few were admitted to the ICU, which was much less than that of adults. As reported by Tang et al (22), almost 26-32% of adult patients were committed to the ICU. Fever and cough were the dominant symptoms in pediatric patients, of which the frequencies were lower compared with adults (55.49-78.49%).…”

Systematic Review and Meta-analysis of the Effectiveness and Safety of Hydroxychloroquine in COVID-19

“…Furthermore, the major population comprised in this study was non-Hispanic black men whose median age was over 65 years [10]. Numerous reports have indicated that the average age of COVID-19 patients was about 50 years, and the gender distribution was nearly equal [33][34][35].…”

“…Furthermore, the major population comprised in this study was non-Hispanic black men whose median age was over 65 years [10]. Numerous reports have indicated that the average age of COVID-19 patients was about 50 years, and the gender distribution was nearly equal [33–35]. However, the mortality risk for COVID-19 varies by age, older people might be related to multiple comorbidities and at a higher risk of COVID-19 -related hospitalization than young people [36–38].…”

Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system

“…Elderly (70 years) patients are prone to develop the most complicated infections as confirmed in a recent meta-analysis collecting the results of 147 studies on 20,662 Chinese patients in which the mean patient age was 49 years and 53% of patients were male [ 31 ]. A significant prevalence of cardiovascular comorbidities was also described in this large Chinese cohort, including systemic hypertension (21%), diabetes mellitus (12%), cardiovascular (9%) and cerebrovascular diseases (6%) [ 31 ]. In another large report of 1099 patients with confirmed COVID-19, systemic arterial hypertension and diabetes mellitus were recorded in 23.7% and 16.2% respectively [ 32 ].…”