Clinical characteristics of 1007 intensive care unitpatients with SARS-CoV-2 pneumonia

Глыбочко, П. В.; Fоmin, Victоr; Авдеев, С. Н.; Moiseev, Sergey; Yavorovskiy, Andrey; Brovko, Michail; Umbetova, Karina; Aliev, V.; Буланова, Е Л; Бондаренко, И. З.; Волкова, Ольга Сергіївна; Gaynitdinova, V. V.; Gneusheva, T. Yu.; Дубровин, К В; Капустина, Валентина; Kraeva, V. V.; Merzhoeva, Zamira M.; Нуралиева, Г. С.; Nogtev, Pavel; Panasyuk, V.; Политов, М Е; Popov, Alexander; Popova, Elena N.; Raspopina, N. A.; Royuk, Valery V.; Sorokin, Yu D; Trushenko, Natalia V.; Khalikova, E.Yu.; Tsareva, Natalia A.; Чикина, С. Ю.; Chichkova, N.; Akulkina, Larisa; Bulanov, Nikolai; Ermolova, L.; Zykova, Anastasiia; Kitbalian, A.; Moiseev, A.; Потапов, П. П.; Tao, E.; Sholomova, Victoria; Shchepalina, A.; Yakovleva, Alexandra

doi:10.32756/0869-5490-2020-2-21-29

Cited by 41 publications

(19 citation statements)

References 34 publications

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“…Another study from the USA showed that the proportion of DM among patients hospitalized due to COVID-19 constituted 31.8 %, which was substantially higher than that among non-hospitalized patients with mild disease course (5.4 %) [ 24 ]. A study conducted in Russian Federation on a large cohort of patients presenting with acute respiratory distress syndrome secondary to COVID-19 revealed the underlying DM in 25 % of cases [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study

Dyusupova

Faizova

Yurkovskaya

et al. 2021

Heliyon

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Background Diabetes mellitus (DM) is associated with higher risk of developing infectious disease and COVID-19 is not the exception. There is a need to generate more data on clinical characteristics and risks of COVID19 patients presenting with DM. In this retrospective study we aimed to report on demographic features, clinical data, and outcomes of COVID-19 patients with DM in comparison with age- and sex-matched patients without DM. Methods This was a retrospective study that relied on the nationwide data on all COVID-19 patients who were diagnosed from 14 March to 18 April, 2020. Overall, there were 31 cases with DM for which we randomly matched 4 patients without DM by age and sex. Results COVID-19 patients with associated DM had less beneficial outcomes and more severe disease course both at hospital admission and final diagnosis, as compared with the age and sex- matched non-DM patients. Diabetics were more predisposed to impaired breathing (29.0 % versus 4.9 % in controls), nausea/vomiting (6.5 % versus 0 % in controls) and weakness/lethargy (45.2 % versus 26.0 % in controls). Finally, 48.4 % of diabetics showed the signs of pneumonia on CT scans versus 20.3 % of non-diabetics (p = 0.001), and 32.3 % of DM patients were admitted to intensive care units as compared with just 5.7 % of non-DM patients (p<0.001). Conclusion There is a need to envisage early status monitoring and supportive care in this vulnerable category of patients to enable better prognosis.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study

Dyusupova

Faizova

Yurkovskaya

et al. 2021

Heliyon

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“…Сеченова, куда были включены 1007 больных COVID-19. Авторы показали, что острый респираторный дистресс-синдром, вызванный SARS-CoV-2, чаще развивается у лиц старше 40 лет при наличии сердечно-сосудистых заболеваний, сахарного диабета 2-го типа и/или ожирения [15].…”

Section: Discussionunclassified

COVID-19 in solid organ transplant recipients: initial report from national multicenter observational study «ROKKOR-recipient»

Gautier

Шевченко

Цирульникова

et al. 2020

RJTAO

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We herein present our initial report from «ROKKOR-recipient», a national multicenter observational study. The prevalence, risk factors, clinical manifestations and outcomes of the novel coronavirus disease 2019 (COVID-19) in solid organ transplant recipients receiving immunosuppressive therapy were investigated. The study enrolled 251 COVID-19 patients (220 kidney recipients, 7 liver recipients, 1 liver-kidney recipient, and 23 heart recipients). The subjects came from 20 regions in Russia. The symptoms, clinical presentation, imaging and lab test results, therapy and outcomes of COVID-19 were described. It was established that solid organ transplant recipients with COVID-19 have a higher risk of developing adverse events. Predictors of adverse events include associated cardiovascular diseases, pulmonary diseases, diabetes, and kidney failure. Symptoms of the disease include dyspnea, rash and catarrhal signs, as well as initial low blood oxygen saturation (SpO2 <92%), leukocytosis (white blood cell count >10 × 109/L), elevated creatinine levels (>130 μmol/L) and a marked decrease in glomerular filtration rate, requiring hemodialysis. Performing organ transplant surgery in COVID-19 does not increase the risk of adverse events but could save the lives of waitlisted terminally ill patients.

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“…Сходные данные получены и в нашем ретроспективном исследовании на основании анализа более 1 тыс. пациентов с SARS-CoV-2-пневмонией, которым потребовались респираторная поддержка и госпитализация в отделение реанимации и интенсивной терапии (ОРИТ) лечебных учреждений Российской Федерации [8]. Более 90% этих пациентов в возрасте старше 40 лет, а у 70% имелись различные сопутствующие заболевания, в том числе артериальная гипертония (АГ), ишемическая болезнь сердца (ИБС), фибрилляция предсердий (ФП), инсульт в анамнезе и др.…”

Section: сведения об авторахunclassified

Risk factors for the early development of septic shock in patients with severe COVID-19

Glybochko

Fоmin

Avdeev

et al. 2020

Terapevticheskii arkhiv

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Aim. In a retrospective study, we evaluated factors associated with the early development of septic shock in patients with severe COVID-19. Materials and methods. We collected medical records of the intensive care unit patients submitted by the local COVID-19 hospitals across Russia to the Federal Center for the Critical Care at the Sechenov First Moscow State Medical University (Sechenov University). Septic shock in crticially ill patients requiring mechanical ventilation was defined as a need in vasopressors to maintain blood pressure. Results. We studied 1078 patients with severe COVID-19 who were admitted to the intensive care units for respiratory support. There were 611 males and 467 females. The mean age was 61.013.7 years. Five hundred twenty five medical records (48.7%) were received from the Moscow hospitals, 159 (14.7%) from the Moscow region, and 394 (36.5%) from the hospitals located in 58 regions of the Russian Federation. In 613 (56.9%) patients, diagnosis of SARS-CoV-2 infection was confirmed by PCR, and in the other cases it was established on the basis of the clinical picture and the results of the chest CT scan. Septic shock developed in 214 (19.9%) of 1078 patients. In the logistic regression model, the risk of septic shock in patients older than 50 years was higher than in patients of a younger age (OR 2.34; 95% CI 1.533.67; p0.0001). In patients with more severe SARS-CoV-2 infection, there was an increase in the prevalence of cardiovascular diseases, including coronary heart disease and atrial fibrillation, type 2 diabetes and malignant tumors. The risk of septic shock in patients with three or more concomitant diseases was higher than in patients without any concomitant chronic diseases (OR 1.76; 95% CI 1.762.70). Conclusion. The risk of septic shock in patients with acute respiratory distress syndrome induced by SARS-CoV-2 is higher in patients older than 50 years with concomitant diseases, although a severe course of the disease is also possible in younger patients without any concomitant disorders.

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Clinical characteristics of 1007 intensive care unitpatients with SARS-CoV-2 pneumonia

Abstract: Федеральный дистанционный консультативный центр анестезиологии и реаниматологии на базе Первого МГМУ им. И.М. Сеченова

Cited by 41 publications

References 34 publications

Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study

Clinical characteristics and risk factors for disease severity and mortality of COVID-19 patients with diabetes mellitus in Kazakhstan: A nationwide study

COVID-19 in solid organ transplant recipients: initial report from national multicenter observational study «ROKKOR-recipient»

Risk factors for the early development of septic shock in patients with severe COVID-19

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