Clinical Characteristics in Patients with Rheumatoid Arthritis: Differences between Genders

Intriago, María; Maldonado, Génessis; Cárdenas, Jenny; Ríos, Carlos

doi:10.1155/2019/8103812

Cited by 45 publications

(49 citation statements)

References 26 publications

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“…Polyarthritis was the presenting symptom in all the cases mostly with EMS (63.3%) and deformity (16.66%), which was very similar to a study done in Kolkata, India. [ 16 ] The mean duration was 32.7 months at presentation which is in accordance with a study done in Kathmandu, Nepal. [ 17 ] The joint inflammation and muscle atrophy due to the disease reduces the range of motion of joints.…”

Section: Discussionsupporting

confidence: 86%

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A cross-sectional study of association of serostatus and extra-articular manifestations in patients with rheumatoid arthritis in a teaching hospital

Kumar

Das

Misra

2020

J Family Med Prim Care

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Background: Rheumatoid arthritis (RA) is an autoimmune disease, which mistakenly attacks the joints and induces the inflammatory changes that thicken the joints (the synovium) resulting in swelling and pain in and around the joints. It causes pain, joint deformity, and also affects the quality of life. The joint is affected symmetrically. It also can affect body systems, such as the cardiovascular, respiratory systems, or other systems, which manifest as extra-articular manifestations. Extra-articular manifestations of RA are documented less in India hence this study was undertaken to correlate RA with extra-articular manifestations as well as its relationship with serostatus in patients with extra-articular manifestations. Materials and Methods: Sixty patients (age between 18–60 years) attending Medicine/Rheumatology outpatient department were included in the study (12 months) who fulfilled the 2010 RA classification criteria laid down by American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) for RA. All the subjects underwent a thorough history, clinical examination, and laboratory investigations. The relevant data were analyzed with appropriate statistical methods after 12 months’ duration. Results: Nearly 68.33% of the subjects were found to have extra-articular manifestations mostly in the age group of 31–40 years with prevalence higher in the female. In the seropositive patients, early morning stiffness (EMS) constitutes 63.82% of the total extra-articular manifestations in the patients followed by anemia (38.29%) and peripheral neuropathy (34.04%). On the other hand, in the seronegative cases, EMS (61.53%) followed by anemia (23.07), peripheral neuropathy (15.38%), and keratoconjunctivitis sicca (15.38%). Extra-articular manifestations in seropositive patients have a statistically significant relationship with the increase in the duration of the disease. Conclusion: Extra-articular manifestations need to be looked carefully as it is associated with more severe disease. Seropositivity and extra-articular manifestations both usually indicate that the RA is more severe and may affect the quality of life.

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Section: Discussionsupporting

confidence: 86%

“…[ 14 ] Females had a higher incidence than males in the study, which was in accordance with two similar studies done in India. [ 15 16 ] It was found that nearly 85% of females had an insidious onset.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of association of serostatus and extra-articular manifestations in patients with rheumatoid arthritis in a teaching hospital

Kumar

Das

Misra

2020

J Family Med Prim Care

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“…It has been reported that females have a more aggressive RA disease with increased activity of the disease and disability. [ 31 ] Owing to these findings, periodontitis severity in different gender among the RA and OA groups was compared in this study. No significant difference was found between the mean CAL values in males and females of both the groups.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and severity of periodontitis in patients with established rheumatoid arthritis and osteoarthritis

Disale

Zope

Suragimath

et al. 2020

J Family Med Prim Care

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Introduction: Periodontitis is associated with many chronic health conditions including diabetes, cardiovascular disease, and rheumatoid arthritis (RA). RA and periodontitis have similarities in inflammatory mechanism, morphology, and histopathology. Osteoarthritis (OA) is a chronic, multifactorial degenerative disease characterized by the deterioration of cartilage in joints. Objective: The aim of this study was to evaluate the prevalence and severity of periodontal disease in patients with established RA and OA. Materials and Methods: A total of 200 patients reporting to the Department of Orthopaedics, KIMSDU, Karad were included in the study. Patients were divided into two groups: Group 1 that included 100 patients with established RA diagnosed according to American College of Rheumatology (ACR) classification 1987 criteria and Group 2 that comprised 100 patients diagnosed with OA. Demographic profile, medical and dental history, oral hygiene practices, and smoking status of study participants were recorded. Periodontal status of the patients were evaluated using the simplified oral hygiene index (OHI-S), Loe and Silness gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL). On the basis of the CAL score periodontitis severity was defined as slight, moderate, and severe. Rheumatoid Factor (RF) and C-reactive protein (CRP) were considered as a serological marker in RA. Serological tests were performed to measure RF and CRP. Periodontal parameters and serological tests were correlated. Results: This study reported 45% severe periodontitis prevalence in RA compared to OA group, which was 33%. Severity of periodontitis is significantly greater in RF positive RA group with mean CAL 5.38 mm compared to RF negative RA group with mean CAL 2.81 mm ( P = 0.001). There was moderate positive correlation found between RF titer and severity of periodontitis (r = 0.311). Conclusion: The severity of periodontitis was significantly higher among the patients with established RA as compared to patients with OA. RF positive patients had higher periodontal disease compared to RF negative patients. There was an increase in the mean clinical attachment loss with increase in RF titer.

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“…Aurrecoechea et al25 found that women had worse QoL than men. This is not surprising, as women tend to experience more pain,26 show higher disease activity,27 and have higher rates of disability,28 all of which influence QoL. Wallenius et al29 reported that a higher level of education was associated with better QoL, which could illustrate the role of patient knowledge and understanding about their condition in their ability to cope with it.…”

Section: Discussionmentioning

confidence: 99%

<p>Quality of life in Ecuadorian patients with established rheumatoid arthritis</p>

Intriago

Maldonado

Cárdenas

et al. 2019

OARRR

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Purpose To evaluate quality of life in patients with established rheumatoid arthritis (RA) and identify the factors that negatively affect it. Methods This was a cross-sectional study with patients with established RA from a rheumatology center in Ecuador. The RA Quality of Life (RAQoL) questionnaire was used to assess QoL and the Health Assessment Questionnaire — disability index (HAQ-DI) questionnaire for functional capacity. In addition, demographics, clinical characteristics, and markers of disease activity were included. Data were analyzed using SPSS 22. Results Of 186 patients, 89.8% were women, with a mean age of 51 years, 86.6% had symmetrical polyarticular involvement, 40.3% erosions, 46.8% morning stiffness, 46.8% xerophthalmia, and 39.2% fatigue. Depression was the most frequent comorbidity — 42.5%. The mean HAQ-DI score was 0.8, and 26.9% had functional disability. The mean RAQoL score was 7.2. Xerophthalmia, xerostomia, fatigue, morning stiffness, and depression were related to higher scores in the RAQoL ( p <0.05). The mean RAQoL was higher in patients with more disease activity and comorbidities ( p <0.05). Likewise, patients with functional disability had a mean RAQoL score of 15.6 versus 4.1 in patients without disability ( p <0.05). There were positive correlations between RAQoL and ESR, CRP, painful-joint count, swollen-joint count, VAS of pain, and physician assessment ( p <0.05). Conclusion QoL is severely affected in patients with RA. Depression, fatigue, morning stiffness, pain, high disease activity, and disability have a negative effect on QoL in RA. Likewise, patients with more comorbidities and extraarticular manifestations show worse QoL.

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Clinical Characteristics in Patients with Rheumatoid Arthritis: Differences between Genders

Cited by 45 publications

References 26 publications

A cross-sectional study of association of serostatus and extra-articular manifestations in patients with rheumatoid arthritis in a teaching hospital

A cross-sectional study of association of serostatus and extra-articular manifestations in patients with rheumatoid arthritis in a teaching hospital

Prevalence and severity of periodontitis in patients with established rheumatoid arthritis and osteoarthritis

<p>Quality of life in Ecuadorian patients with established rheumatoid arthritis</p>

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