2020
DOI: 10.1093/ofid/ofaa068
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Clinical Characteristics, Etiology, and Initial Management Strategy of Newly Diagnosed Periprosthetic Joint Infection: A Multicenter, Prospective Observational Cohort Study of 783 Patients

Abstract: Background Periprosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. Most observational studies of PJI are retrospective or single-center, and reported management approaches and outcomes vary widely. We hypothesized that there would be substantial heterogeneity in PJI management and that most PJIs would present as late acute infections occurring as a consequence of bloodstream infections. Methods … Show more

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Cited by 38 publications
(47 citation statements)
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“…Accurate knowledge of the microbiologic etiology of PJI is critical to choosing appropriate antimicrobials and has prognostic implications. Studies on this topic are based on cohort data from the 1990s to early 2000s, small sample sizes, or non-United States data (4)(5)(6).…”
Section: Introductionmentioning
confidence: 99%
“…Accurate knowledge of the microbiologic etiology of PJI is critical to choosing appropriate antimicrobials and has prognostic implications. Studies on this topic are based on cohort data from the 1990s to early 2000s, small sample sizes, or non-United States data (4)(5)(6).…”
Section: Introductionmentioning
confidence: 99%
“…Although multiple bacterial pathogens have been associated with PJIs, S. aureus is often reported as the most common cause, accounting for approximately 13-44 % of all PJIs (Aggarwal et al, 2014;Manning et al, 2020;Pulido et al, 2008;Tsai et al, 2019). Treatments for PJIs include long courses of antibiotics, debridement of infected tissue and implant removal and replacement (Pelt et al, 2014;Segawa et al, 1999).…”
Section: Introductionmentioning
confidence: 99%
“…Although multiple bacterial pathogens have been associated with PJIs, S. aureus is often reported as the most common cause, accounting for approximately 13-44 % of all PJIs ( Aggarwal et al, 2014 ; Manning et al, 2020 ; Pulido et al, 2008 ; Tsai et al, 2019 ). Treatments for PJIs include long courses of antibiotics, debridement of infected tissue and implant removal and replacement ( Pelt et al, 2014 ; Segawa et al, 1999 ).…”
Section: Introductionmentioning
confidence: 99%