Clinical characteristics and treatment outcomes of secondary ocular adnexal lymphoma

He, Weimin; Yang, Yu; Jin, Xin; Wang, Yujiao; Ma, Ruixin

doi:10.1111/ceo.14189

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…O cular adnexal lymphoma (OAL) is the most common malignant tumor of the eye in adults, with involvement of the conjunctiva, eyelids, orbit, and any soft tissues within the orbit. It accounts for approximately 8%-20% of ocular adnexal tumors [1][2] and 10.33%-49% of malignant eye tumors [3][4][5] . Ocular adnexal mucosa associated lymphoid tissue lymphoma (OAML) represents the most common pathological subtype of OAL [6][7] .…”

Section: Introductionmentioning

confidence: 99%

Guiding function of positron emission tomography-computed tomography examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma

Zhang,

Liu,

et al. 2024

Int J Ophthalmol

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AIM: To explore the role of positron emission tomography-computed tomography (PET-CT) examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma (OAML). METHODS: The general clinical data, postoperative PET-CT results, treatment regimens, and the prognosis of 21 histopathologically confirmed OAML patients between October 2017 and September 2021 were collected. Among the 21 patients, five patients underwent surgical treatment alone, 13 patients underwent surgical treatment combined with radiotherapy, and three patients underwent surgical treatment combined with chemotherapy. RESULTS: The follow-up period ranged from 8 to 79mo, with four cases of recurrence and no deaths. Through PET-CT examination, two patients exhibited both local ocular metabolic elevation and systemic metastasis, and one of these patients had cervical lymph node metastasis, while the other had submandibular and parotid gland metastasis. Nine patients showed only local ocular metabolic elevation, while 10 patients had no abnormal metabolic activity locally. CONCLUSION: PET-CT examination plays a crucial role in detecting residual lesions and recurrence following tumor resection, aiding in precise disease staging, and facilitating the development of personalized treatment plans, ultimately improving patient prognosis.

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Section: Introductionmentioning

confidence: 99%

Guiding function of positron emission tomography-computed tomography examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma

Zhang,

Liu,

et al. 2024

Int J Ophthalmol

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“…Low-grade malignant follicular lymphoma (FL) is the second most common primary subtype, but the most common subtype of secondary orbital lymphomas (Fig. 1, 2) [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Fine-Needle Aspiration Biopsy as a Diagnostic Modality for Orbital Adnexal Lymphoma

Dan,

Norin,

Dafgård Kopp

et al. 2023

Acta Cytologica

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Purpose To evaluate fine-needle aspiration biopsy (FNAB) as a diagnostic tool for lymphoproliferative orbital lesions in light of recent improvements in cytomorphological and immunologic analyses. Method Retrospective case series including all orbital FNABs with a lymphoproliferative outcome at Karolinska University Hospital, Stockholm, Sweden during the period 2005-2015. Results Of the 38 patients included, 31 (82%) were conclusively diagnosed as having lymphoma according to the first FNAB. Disease in 20 patients (65%) could be sub-classified. The diagnosis in seven patients (18%) was either inconclusive, suggestive of lymphoma, or reactive lymphatic infiltrate. These seven patients were re-investigated, and the initial suspected diagnosis of malignant lymphoma was confirmed in four. Two of the remaining three patients were initially diagnosed as having non-lymphoproliferative disease, however, this was later changed to a lympho¬proliferative diagnosis following re-investigation, while the results of both reFNAB and incisional biopsy were inconclusive in the third. Conclusion In the majority of the 38 patients, a definitive diagnosis of lymphoma could be made based on FNAB alone, using cytomorphological and immunological workup, and sub-classification was possible in 20 patients (65%). Primary low-grade malignant orbital lymphomas are traditionally treated with low-dose radiotherapy regardless of subtype, and incisional biopsy was not needed to initiate treatment. Our findings suggest that FNAB is a valid first option for the diagnosis of suspected orbital lymphomas due to the minimal risk of complications compared to incisional biopsy, and the fact that it can be performed as an outpatient procedure with no anesthesia.

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“…Primary lymphomas are biopsy-confirmed cases originating in the ocular and adnexal regions, while secondary lymphomas have spread to these tissues from other parts of the body or represent relapses of previously diagnosed systemic lymphomas. 19 The co-occurrence of IOL and OAL is highly uncommon. 20 Diagnosing IOL and OAL is challenging for both ophthalmologists and pathologists, as they can mimic steroid-resistant ocular inflammation, orbital cellulitis, and orbital pseudotumor.…”

mentioning

confidence: 99%

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

Rafizadeh,

Ghahvehchian,

Rajabi

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review the existing literature on patients with anaplastic large cell lymphoma (ALCL) affecting the globe and/or ocular adnexa, and to present a report documenting the clinical course of a patient with ALCL that involved their globe and ocular adnexa. Methods: PubMed, Scopus, and Google scholar were systematically searched for all cases of ALCL involving intraocular or adnexal ocular structures from inception to May 2023. Moreover, a new reported case added to the cases found in searches. Results: The review identified 1680 studies, with 8 meeting inclusion criteria. A total of 9 patients were included with a mean age of 29.7 years (median: 30.0, range: 1.3–48). Primary ALCL was present in 5/9 (55.6%) patients. The most common ophthalmic manifestations included periorbital swelling (5/8), chemosis (5.8), and decreased vision (5/7). Misdiagnoses were initially made in 3 patients, and the lag time to correct diagnosis from 3 weeks to 3 months. CD30 expression was positive in all cases, and 6/9 patients were positive for anaplastic lymphoma kinase, resulting in 6/9 patients being diagnosed with anaplastic lymphoma kinase-positive ALCL. In terms of management modalities, chemotherapy was administered in 8/9 patients, while radiation therapy was utilized in 4/9 patients, and 2 underwent autologous stem cell transplantation. Five (55.6%) patients succumbed to ALCL while 4 (44.4%) were alive and disease-free at the last follow-up. The median times from the initial presentation of ALCL to death, ophthalmic presentation to death, and diagnosis to death were 4.12 months (range: 1.1–168.0), 2.62 months (range: 1.1–144), and 4.00 months (range: 0.10–168), respectively. The median follow-up duration was 21.0 months (range: 1.1–168.0). Conclusions: ALCL involving the globe and ocular adnexa is a rare and highly malignant tumor that can mimic benign clinical conditions. Early biopsy and aggressive treatment with chemotherapy regimens such as CHOP and radiation therapy may be useful.

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Clinical characteristics and treatment outcomes of secondary ocular adnexal lymphoma

Cited by 3 publications

References 23 publications

Guiding function of positron emission tomography-computed tomography examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma

Guiding function of positron emission tomography-computed tomography examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma

Fine-Needle Aspiration Biopsy as a Diagnostic Modality for Orbital Adnexal Lymphoma

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

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