Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study

Qiao, Shi Zhang; Zhang, Xiaoyi; Jiang, Fan; Zhang, Xuanzhe; Bimu, Chibu; Feng, Jing; Yan, Shuicheng; Guan, Yongjun; Xu, Dongxue; He, Guangzhen; Chen, Chen; Xiong, Xingcheng; Liu, Lei; Li, Hanjun; Jiang, Tao; Peng, Zhiyong; Wang, Weixing

doi:10.2337/figshare.12210008.v1

Cited by 17 publications

(21 citation statements)

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“…Data from China confirmed not only that diabetes is a risk factor for the progression and progress of COVID-19 infections ( 13 ) but also that among inpatients with diabetes and COVID-19 infection, nonsurvivors were older, mostly male, and more likely to have hypertension and cardiovascular disease ( 14 ). Similarly, those at risk for diabetic foot disease are older, 1.5 times more likely to be male, and typically have other comorbidities, especially cardiovascular and renal disease ( 1 , 2 , 4 , 15 ).…”

Section: Discussionmentioning

confidence: 91%

Saving the Diabetic Foot During the COVID-19 Pandemic: A Tale of Two Cities

et al. 2020

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Of all the late complications of diabetes, those involving the foot have traditionally required more face-to-face patient visits to clinics to treat wounds by debridement, offloading, and many other treatment modalities. The advent of the coronavirus disease 2019 (COVID-19) pandemic has resulted not only in the closing of most outpatient clinics for face-to-face consultations but also in the inability to perform most laboratory and imaging investigations. This has resulted in a paradigm shift in the delivery of care for those with diabetic foot ulcers. The approaches to this challenge in two centers with an interest in diabetic foot disease, including virtual consultations using physician-to-patient and physician–to–home nurse telemedicine as well as home podiatry visits, are described in this review and are illustrated by several case vignettes. The outcomes from these two centers suggest that we may be witnessing new possibilities in models of care for the diabetic foot.

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Section: Discussionmentioning

confidence: 91%

Saving the Diabetic Foot During the COVID-19 Pandemic: A Tale of Two Cities

et al. 2020

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“…Thirty-nine studies compared the D-dimer levels between a total of 5759 severe and 2063 non-severe patients . Sixteen studies compared the D-dimer levels between a total of 2783 surviving and 697 non-surviving patients [39,[55][56][57][58][59][60][61][62][63][64][65][66][67][68][69]. All the studies except for one were performed outside China [64].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis

Güngör

Atıcı

Baycan

et al. 2021

The American Journal of Emergency Medicine

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Background In this systematic review and meta-analysis, we aimed to investigate the correlation of D-dimer levels measured on admission with disease severity and the risk of death in patients with coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods We performed a comprehensive literature search from several databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in abstracting data and assessing validity. Quality assessment was performed using the Newcastle-Ottawa quality assessment scale (NOS). D-dimer levels were pooled and compared between severe/non-severe and surviving/non-surviving patient groups. Weighted mean difference (WMD), risk ratios (RRs) and 95% confidence intervals (CIs) were analyzed. Results Thirty-nine studies reported on D-dimer levels in 5750 non-severe and 2063 severe patients and 16 studies reported on D-dimer levels in 2783 surviving and 697 non-surviving cases. D-dimer levels were significantly higher in patients with severe clinical status (WMD: 0.45 mg/L, 95% CI: 0.34–0.56; p < 0.0001). Non-surviving patients had significantly higher D-dimer levels compared to surviving patients (WMD: 5.32 mg/L, 95% CI: 3.90–6.73; p < 0.0001). D-dimer levels above the upper limit of normal (ULN) was associated with higher risk of severity (RR: 1.58, 95% CI: 1.25–2.00; p < 0.0001) and mortality (RR: 1.82, 95% CI: 1.40–2.37; p < 0.0001). Conclusion Increased levels of D-dimer levels measured on admission are significantly correlated with the severity of COVID-19 pneumonia and may predict mortality in hospitalized patients.

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“…As of 15 August 2020, there have been 23 035 total cases in Australia, with 379 deaths 3 . Elderly patients and those with co‐morbidities including diabetes, hypertension and asthma are at increased risk for poor outcomes 4 . Clinical characteristics and outcomes have been varied in previously published cohorts internationally, 5–7 but have not been studied in an Australian cohort to date.…”

Section: Introductionmentioning

confidence: 99%

Demographics, clinical characteristics and outcomes among 197 patients with COVID‐19 in the Gold Coast area

O'Brolchain

Ulett

et al. 2021

Internal Medicine Journal

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Background Clinical characteristics and outcomes of coronavirus disease 2019 (COVID‐19) patients have been varied internationally but have not been studied in an Australian cohort. Aim To describe characteristics and outcomes of approximately the first 200 documented COVID‐19 cases during the first outbreak in the Gold Coast. Methods Retrospective observational cohort study of COVID‐19 patients managed by Gold Coast Hospital and Health Service (GCHHS). Demographics, clinical characteristics and outcomes data were collected. Results One hundred and ninety‐seven patients were included (mean age 45 years); 52.3% were female and 9.1% were healthcare workers. Most were overseas travellers (53.8%), contacts of a local confirmed case (25.4%) or cruise ship passengers (17.3%). The commonest comorbidities were hypertension (14.2%) and asthma (11.2%). The commonest symptoms were cough (74.1%), fever (58.9%), sore throat (48.7%), headache (48.7%) and rhinorrhoea (46.2%). Sixty‐three patients were hospitalised and the rest admitted to a ‘virtual ward’. Of 63 hospitalised patients, 5 (7.9%) required intensive care unit (ICU) admission and 3 (4.8%) required intubation. No patients died. Due to low numbers of accurate exposure dates, the incubation period could not be reliably calculated for a significant proportion of the cohort. Average duration of symptoms was 14 days, time from first symptom to hospitalisation was 5.3 days and time from first symptom to ICU admission was 11.6 days. The majority (88%) experienced mild disease and achieved complete symptom resolution (97%). Nasopharyngeal swab polymerase chain reaction was the main diagnostic method (99%). Twenty‐four patients received anti‐viral pharmacotherapy, with 87.5% getting hydroxychloroquine. Conclusions The present study provides characteristics and outcomes of the first 197 patients with COVID‐19 in the Gold Coast.

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Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study

Cited by 17 publications

References 0 publications

Saving the Diabetic Foot During the COVID-19 Pandemic: A Tale of Two Cities

Saving the Diabetic Foot During the COVID-19 Pandemic: A Tale of Two Cities

Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis

Demographics, clinical characteristics and outcomes among 197 patients with COVID‐19 in the Gold Coast area

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