Clinical Characteristics and Risk Factors for Fatality and Severity in Patients with Coronavirus Disease in Korea: A Nationwide Population-Based Retrospective Study Using the Korean Health Insurance Review and Assessment Service (HIRA) Database

Lee, Seung-Geun; Park, Geun U; Moon, Yeo Rae; Sung, Kihoon

doi:10.3390/ijerph17228559

Cited by 27 publications

(38 citation statements)

References 27 publications

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“…In studies which reported BMI, we observed higher rates of obesity (BMI�30kg/m 2 ) in patients with severe disease (OR = 1.89, 95% CI: 1.44-2.46; I 2 = 0.0%) [20,21,23,26,30,35]. [26,28,35,38,45] showed no significant differences between patients with severe and non-severe disease.…”

Section: Demographic Characteristicsmentioning

confidence: 54%

Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis

et al. 2021

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Objective We aimed to systematically identify the possible risk factors responsible for severe cases. Methods We searched PubMed, Embase, Web of science and Cochrane Library for epidemiological studies of confirmed COVID-19, which include information about clinical characteristics and severity of patients’ disease. We analyzed the potential associations between clinical characteristics and severe cases. Results We identified a total of 41 eligible studies including 21060 patients with COVID-19. Severe cases were potentially associated with advanced age (Standard Mean Difference (SMD) = 1.73, 95% CI: 1.34–2.12), male gender (Odds Ratio (OR) = 1.51, 95% CI:1.33–1.71), obesity (OR = 1.89, 95% CI: 1.44–2.46), history of smoking (OR = 1.40, 95% CI:1.06–1.85), hypertension (OR = 2.42, 95% CI: 2.03–2.88), diabetes (OR = 2.40, 95% CI: 1.98–2.91), coronary heart disease (OR: 2.87, 95% CI: 2.22–3.71), chronic kidney disease (CKD) (OR = 2.97, 95% CI: 1.63–5.41), cerebrovascular disease (OR = 2.47, 95% CI: 1.54–3.97), chronic obstructive pulmonary disease (COPD) (OR = 2.88, 95% CI: 1.89–4.38), malignancy (OR = 2.60, 95% CI: 2.00–3.40), and chronic liver disease (OR = 1.51, 95% CI: 1.06–2.17). Acute respiratory distress syndrome (ARDS) (OR = 39.59, 95% CI: 19.99–78.41), shock (OR = 21.50, 95% CI: 10.49–44.06) and acute kidney injury (AKI) (OR = 8.84, 95% CI: 4.34–18.00) were most likely to prevent recovery. In summary, patients with severe conditions had a higher rate of comorbidities and complications than patients with non-severe conditions. Conclusion Patients who were male, with advanced age, obesity, a history of smoking, hypertension, diabetes, malignancy, coronary heart disease, hypertension, chronic liver disease, COPD, or CKD are more likely to develop severe COVID-19 symptoms. ARDS, shock and AKI were thought to be the main hinderances to recovery.

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Section: Demographic Characteristicsmentioning

confidence: 54%

Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis

et al. 2021

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“…All studies evaluated data from retrospective patient cohorts, except for four (9.3%) that collected the information prospectively [ 39 , 40 , 56 , 69 ]. Six (14.0%) studies reported population-based data [ 35 , 36 , 42 , 52 , 59 , 62 ], while the others were conducted in a hospital setting. Two (4.7%) studies also included COVID-19 patients based on high clinical or radiological suspicion [ 39 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…Most investigators reviewed patient records or used tuberculosis-related diagnostic codes in databases to identify patients having active tuberculosis ( Table 1 ). Fourteen (32.6%) studies reported human immunodeficiency virus (HIV) seroprevalence in their patient cohorts [ 36 , 37 , 42 , 48 – 50 , 58 – 60 , 62 , 64 , 67 , 69 , 71 ]. Of these, a single study from South Africa provided tuberculosis prevalence and outcome data based on HIV status [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

et al. 2021

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Objective The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. Methods We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. Results We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. Conclusion Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.

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“…Most studies to date have investigated risk factors associated with the severity of COVID-19. Older patients, male gender, patients had diabetes mellitus, chronic kidney disease, and CVD rate in comorbidities, previous history of pneumonia, dyspnea, headache and neurological symptoms, increase respiratory rates and pulse rate, anemia, malaria infection, neutrophilia, lymphcytopenia, higher glucose levels, HbA1c levels and creatinine levels, increase levels of CRP and d-dimer were associated with increased risks of severe COVID-19 and increase the risk of death from COVID-19 (8)(9)(10). However, little is…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics And Analysis Of Risk Factors For Disease Progression Of COVID-19 Among Patients Within Wad Medani Isolation Centers, Gezira State: A Retrospective Cohort Study From Sudan

Yousif¹,

Eljack²,

Amir³

et al. 2021

Preprint

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Background : (COVID-19) had a great impact on the world’s health systems since December 2019. A little is known about the clinical characteristics and risk factors associated with COVID-19 severity in Sudanese Patients; therefor it is necessary to summarize the clinical characteristics of patients with COVID-19 and to explore the risk factors associated with COVID-19 severity. Methods : A one-year retrospective cohort study (May 2020- May2021) was done at three isolation centers in Wad Medani. Sample contained all COVID-19 patients who are over 18 years old and were confirmed to be COVID-19 by nucleic acid testing or features Suggestive of Covid19 on Chest CT scan. Results : This study included 418 patients confirmed COVID-19 cases with a median age of 66.3±13years. 179 (64.2%) patients were men. Hypertension (n=195; 46.7%) and diabetes (n=187; 44.7%) were the most common comorbidities. The most common symptoms at COVID-19 onset were fever (n=303; 72.5%), cough (n=278; 66.5%) and dyspnea (n= 256; 61.2%). the overall mortality rate was 35.4% (n=148). The morality rate was 42.3% (n=118) among patients with severe disease. The Chi-square test and ANOVA analysis revealed that older age, anemia, neutrophilia and lymphcytopenia, higher glucose levels, HbA1c levels and creatinine levels were variables associated with severe COVID-19. In inflammatory markers, the levels of CRP and d-dimer were elevated in severe infection more than moderate and mild infections. Conclusion : Patients with these factors are more likely to deteriorate into severe infection and have higher mortality rate than those without these factors.

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Clinical Characteristics and Risk Factors for Fatality and Severity in Patients with Coronavirus Disease in Korea: A Nationwide Population-Based Retrospective Study Using the Korean Health Insurance Review and Assessment Service (HIRA) Database

Cited by 27 publications

References 27 publications

Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis

Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

Clinical Characteristics And Analysis Of Risk Factors For Disease Progression Of COVID-19 Among Patients Within Wad Medani Isolation Centers, Gezira State: A Retrospective Cohort Study From Sudan

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