Clinical Characteristics and Risk Factors for the Recurrence of Benign Paroxysmal Positional Vertigo

Zhu, Cui Ting; Zhao, Xiaohui; Ju, Yang; Chen, Mei Mei

doi:10.3389/fneur.2019.01190

Cited by 40 publications

(54 citation statements)

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“…Some studies have investigated associations between vascular risk factors and BPPV, such as hypertension, DM, and hyperlipidemia, but the results were controversial (4,19). In addition, vascular comorbidities may also be risk factors for BPPV recurrence (8,9). However, our analysis showed that migraine and high TC level were risk factors for BPPV occurrence, while HTN, DM, hyperlipidemia, and stroke were not.…”

Section: Discussionmentioning

confidence: 62%

“…This relationship may be related to estrogen deficiency in postmenopausal women, as estrogen may promote the development of osteoporosis and even BPPV (18). In addition, women BPPV patients have a higher risk of recurrence than men (9,31). Therefore, further research between estrogen levels and BPPV may help early diagnosis and prevention of BPPV.…”

Section: Discussionmentioning

confidence: 99%

“…Although canalith repositioning maneuver is an effective treatment for BPPV, nearly 50% of patients experienced at least one recurrence in 2 years after treatment (8). Many of the risk factors investigated in this meta-analysis, such as hypertension and migraine, may also be risk factors for BPPV recurrence, which may help improve the treatment and prognosis of this disease (9).…”

Section: Introductionmentioning

confidence: 88%

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Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

et al. 2020

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Background and Purpose: The lifetime prevalence of benign paroxysmal positional vertigo (BPPV) is high, especially in the elderly. Patients with BPPV are more susceptible to ischemic stroke, dementia, and fractures, severely reducing quality of life of patients. Many studies have analyzed risk factors for the occurrence of BPPV. However, the results of these studies are not identical. We performed this meta-analysis to determine potential risk factors associated with the occurrence of BPPV. Methods: PubMed, EMBASE, and the Cochrane Library (January 2000 through March 2020) were systematically searched for eligible studies analyzing risk factors for the occurrence of BPPV. Reference lists of eligible studies were also reviewed. We selected observational studies in English with a control group and sufficient data. Pooled odds ratios (ORs) or the mean differences (MDs) and 95% confidence intervals (CIs) were calculated to measure the impacts of all potential risk factors. Heterogeneity among studies was evaluated using the Q-test and I 2 statistics. We used the randomeffect model or the fixed-effect model according to the heterogeneity among the included studies. Results: We eventually included 19 studies published between 2006 and 2019, including 2,618 patients with BPPV and 11,668 participants without BPPV in total. In this meta-analysis, the occurrence of BPPV was significantly associated with female gender (OR = 1.18; 95% CI, 1.05-1.32; P = 0.004), serum vitamin D level (MD = −2.12; 95% CI, −3.85 to −0.38; P = 0.02), osteoporosis (OR = 2.49; 95% CI, 1.39-4.46; P = 0.002), migraine (OR = 4.40; 95% CI, 2.67-7.25; P < 0.00001), head trauma (OR = 3.42; 95% CI, 1.21-9.70; P = 0.02), and total cholesterol level (MD = 0.32; 95% CI, 0.02-0.62; P = 0.03). Conclusion: Female gender, vitamin D deficiency, osteoporosis, migraine, head trauma, and high TC level were risk factors for the occurrence of BPPV. However, the effects of other risk factors on BPPV occurrence need further investigations.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

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Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

et al. 2020

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“…The morbidity of BPPV in male and female is 1:1.5-2, which is usually high after 40 years old and increases with age (4). In addition, some studies have found that age does not increase the recurrence rate of BPPV (10).We found the recurrence of females was 3.79 fold which signi cantly higher than male but the female -to-male ratio was 1.82 to 1 in total patients. In theory, with the increase of age, the function of human organs gradually decline.…”

Section: Discussionmentioning

confidence: 40%

“…As we all know, age, gender, sex hormones, osteoporosis, hypertension, hyperlipidemia, diabetes and hyperuricemia are all considered as risk factors of BPPV (6)(7)(8)(9). According to previous study that cerebrovascular risk factors in uenced BPPV recurrence (10). The morbidity of BPPV in male and female is 1:1.5-2, which is usually high after 40 years old and increases with age (4).…”

Section: Discussionmentioning

confidence: 99%

Unhealthy lifestyle is an important risk factor for BPPV recurrence

Fu¹,

Zhang²,

Jin³

et al. 2020

Preprint

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Background: Benign paroxysmal positional vertigo (BPPV) is self-limiting and recurrent but the cost is considerable. The recurrence of BPPV increased significantly under the quarantine policy in Hangzhou. The unhealthy lifestyle risk factors of the recurrence of BPPV have not yet been investigated. So, the objective is to analyze the unhealthy lifestyle risk factors of recurrent BPPV.Methods: A retrospective observational study was conducted in the Department of Neurology in Tongde Hospital of Zhejiang Province from December 2018 to March 2020. The study included 186 patients aged 23–86 years. All patients received the definitive diagnosis and canalith repositioning maneuvers (CRM) treatment and finally accomplished follow-up for one year. Demographic variables, potential recurrence risk factors, neurological examination, cranial computed tomography and lifestyle were assessed.Data Analyses: The t-test or chi-squared test was first performed for group comparison, then logistic regression analysis was performed to investigate the recurrence risk factors in all of the patients.Results: The 1-year recurrence rates of BPPV patients after reposition maneuvers were 36.02%, is significantly higher than other study especially in the first quarter of 2020 (38.8% of patients with BPPV recurrence). Logistic regression analysis shows that BPPV patients who was poor physical activities and prolonged recumbent position time have more recurrence risks. Poor physical activities (odds ratio =5.690, 95% confidence interval: 1.650-19.618, p <0.006), prolonged recumbent position time (odds ratio = 1.651, 95% confidence interval: 1.370-2.003, p = 0.000), were risk factors for the recurrence of BPPV in patients.Conclusion: We conclude that poor physical activities and prolonged recumbent position time may be independent risk factors for the recurrence of BPPV patients, but aging, Ménière’s disease, sudden deafness migraine, hypertension, hyperlipemia, diabetes, CHD, POCI, mental factors, and mental labor do not increase the recurrence risk.

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Randomized Controlled Trial Assessing Vitamin D's Role in Reducing BPPV Recurrence in Older Adults

Chua,

Huang,

Koh

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveTo determine if the recurrence rates of BPPV in older adults were lower in the vitamin D‐treated group as compared to placebo groups.Study DesignDouble‐blinded randomized control placebo trial.SettingA single‐centre study.MethodsDouble‐blinded randomized controlled trial design with 12 months follow‐up. Vitamin D3 deplete participants were randomized into treatment (Group A) or placebo groups (Group B). Treatment group received 13 weeks of 2000 IU vitamin D3 followed by 1000 IU for the next 13 weeks. Patients who were replete were allocated to a control group (Group C) for observation and follow up. All groups had dietary interventions for vitamin D3 and calcium.ResultsResults showed an 87% reduction in recurrence rates of BPPV in the treatment group (Group A), with 0.75 fewer clinical episodes per 1 person‐year as compared to placebo (Group B). Time to first recurrence was also significantly longer in Group A. There was no statistically significant difference between Group A and C in both recurrence rates and dizziness handicap scores.ConclusionsThis clinical trial has laid the foundation to expand the investigation of vitamin D as standard of care treatment in BPPV patients in future phase IIb and III studies.SummaryA reduction in BPPV episodes in older adults has implications on fall risk, as dizziness from BPPV may cause falls. With fewer BPPV episodes and longer time to recurrence, seniors may have better postural stability and hence reduced risk of falls.Level of Evidence2.

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Clinical Characteristics and Risk Factors for the Recurrence of Benign Paroxysmal Positional Vertigo

Cited by 40 publications

References 32 publications

Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis

Unhealthy lifestyle is an important risk factor for BPPV recurrence

Randomized Controlled Trial Assessing Vitamin D's Role in Reducing BPPV Recurrence in Older Adults

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