Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China

Abstract

Coronavirus disease 2019 (COVID-19) broke out in December 2019. Due its high morbility and mortality, it is necessary to summarize the clinical characteristics of COVID-19 patients to provide more theoretical basis for future treatment. In the current study, we conducted a retrospective analysis of the clinical characteristics of COVID-19 patients and explored the risk factors for the severity of illness. A total of 101 COVID-19 patients hospitalized in Leishenshan Hospital (Wuhan, China) was classified into three sub-types: moderate ( n = 47), severe ( n = 36), and critical ( n = 18); their clinical data were collected from the Electronic Medical Record. We showed that among the 101 COVID-19 patients, the median age was 62 years (IQR 51–74); 50 (49.5%) patients were accompanied by hypertension, while 25 (24.8%) and 22 (21.8%) patients suffered from diabetes and heart diseases, respectively, with complications. All patients were from Wuhan who had a definite history of exposure to the epidemic area. Multivariate logistic regression analysis revealed that older age, diabetes, chronic liver disease, percentage of neutrophils (N%) > 75%, CRP > 4 mg/L, D-dimer > 0.55 mg/L, IL-2R > 710 U/mL, IL-8 > 62 pg/mL, and IL-10 > 9.1 pg/mL were independent variables associated with severe COVID-19. In conclusion, we have identified the independent risk factors for the severity of COVID-19 pneumonia, including older age, diabetes, chronic liver disease, higher levels of N%, CRP, D-dimer, IL-2R, IL-8, and IL-10, providing evidence for more accurate risk prediction.

Elevated Levels of Pleiotropic Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are Critically Involved With the Severity and Mortality of COVID-19: An Updated Longitudinal Meta-Analysis and Systematic Review on 147 Studies

“…We conducted this meta-analysis on overall 31 909 COVID-19 patients from 147 studies. 2 , 4 - 7 , 9 - 18 , 24 …”

SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity

“…M1 was not found to significantly better fit than M2 (Table S6; χ 2 test: score=12.46, d.f.=9, P=0. 19), but M2 significantly better fitted the data than M3 (Table S6; χ 2 test: score=15.49, d.f.=1, P=8.31×10 −5 ) and M4 (Table S6; χ 2 test: score=106.12, d.f.=1, P<2.2×10 −16 ). According to the M2 model (Table S7, and Fig.…”

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID- 19), was first reported in Wuhan, Hubei, China, in late December 2019 [2]. SARS-CoV-2 is a positive-sense ssRNA virus in the family Coronaviridae [3].…”

“…Several host factors correlated with COVID-19 severity have been identified, including patient age [13][14][15], patient gender [15][16][17][18], pre-existing medical conditions such as diabetes and chronic liver disease [15,19], levels of CD4 + and CD8+ T cell counts, levels of IL-6 and IL-8 [20], and genotypes of human leucocyte antigen genes [21]. A number of viral genetic factors associated with the increase in COVID-19 severity have also been characterized.…”

COVID-19: The Impact on Cardiovascular System

“…Cardiovascular disease (CVD) has an important role in COVID-19, not only as a risk factor but also as a predictor of mortality. Preexisting CVD was noted in previous studies with a variable prevalence from 2% to 40%, although new reports suggest that the prevalence of CVD in COVID-19 tends to be higher than in the general population, especially in severe and critical cases [69,70]. A recent meta-analysis including 6270 COVID-19 patients found that 41.1% had associated comorbidities such as hypertension (20.9%), diabetes (9.96%), and CVD (4.8%).…”