“…In rare cases, the breakpoints are located outside the above three regions, which form the atypical fusion transcripts, such as e19a2, e1a2, e8a2, e6a2, e12a2, e13a3, e14a3 and e1a3, and so on 47 . Among these rare transcript types, the frequency of e14a3 in overall CML patients was described in the range from 0.2% to 0.3% according to previous large sample studies 17–19 . Although three important recommended methods (cytogenetics, FISH and RT‐PCR) have been applied for the initial CML diagnosis, absence an of a commercial RT‐PCR kit with customized primers might have resulted in the omission of a number of detections in the past.…”