Clinical Characteristics and Prognosis of 244 Cardiovascular Patients Suffering From Coronavirus Disease in Wuhan, China

Peng, Yudong; Meng, Kai; He, Meian; Zhu, Ruirui; Guan, Hongquan; Ke, Zihan; Leng, Liang; Wang, Xiang; Liu, Bende; Hu, Cao; Ji, Qingwei; Keerman, Mulatibieke; Cheng, Long; Wu, Tangchun; Huang, Kai; Zeng, Qiutang

doi:10.1161/jaha.120.016796

Cited by 59 publications

(77 citation statements)

References 26 publications

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“…25 For example, 88.2% of patients admitted to Wuhan Union Hospital between January and February 2020 who were not survivors of this illness had a BMI > 25 kg/m 2 . 26 Some explanations state that a higher than normal BMI increases susceptibility to respiratory infections due to the deterioration of lung mechanics and higher concentrations of pro-inflammatory molecules. 27 On the other hand, the excessive amount of adipose tissue in the abdominal area decreases diaphragmatic excursion and affects the ventilation of the base of the lung, which can lead to hypoxemia, clinical characteristics observed in this illness.…”

Section: Discussionmentioning

confidence: 99%

Changes in eating habits and lifestyles in Peruvian population during social isolation by the COVID-19 pandemic

Huancahuire-Vega

Newball-Noriega

Rojas-Humpire

et al. 2021

Preprint

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Background: The COVID 19 pandemic caused that some governments have implemented house confinement measures with probable consequences on lifestyle, particularly affecting eating habits, physical activity, sleep quality, and mental health. Objectives: The aim of this study was to assess the frequency of lifestyles, physical activity and sleep characteristics, as well as changes in eating habits in the Peruvian population during COVID-19 pandemic. Methods: A Cross-sectional descriptive study was performed. We analyzed adults from Peru between July to August 2020 based on an online self-administered questionnaire divided into sociodemographic, anthropometrics and COVID 19 diagnostic reported, lifestyle habits and frequency of consumption of foods. Findings: During confinement by COVID-19, 1176 participants were studied, 39% were student, 37.5% were workers and 46% were assert not to work. The population asserted gain weight (1 to 3 Kg) and 35.7% were overweight. The lifestyles habits showed that 54.8% affirmed to doing physical activity and a large proportion (37.2%) asserted sleep less. The Peruvian population presented a main feeding patter of breakfast (95.7%), lunch (97.5%), dinner (89.1%) and brunch (44.9%). Likewise, feeding habits before and during COVID-19 pandemic showed that vegetables (OR:1.56, CI95% 1.21 200), fruit (OR: 1.42, CI95% 1.10 1.81), legumes (OR:1.67, CI95% 1.23 2.28) and eggs (OR: 2.00, CI95% 1.52 2.65) presented significantly consumption increase during social isolation, while bakery products (OR: 0.74, CI95% 0.56 0.97), meat, snack, refreshment and fast-food decrease consumption. Other food no significant differences were presented. Conclusion: This study in a Peruvian population showed an important frequency of overweight and sleep disorders. There was a slight increase in physical activity despite the social isolation measures and an increase in health eating habits, nevertheless a majority reported gaining weight.

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Section: Discussionmentioning

confidence: 99%

Changes in eating habits and lifestyles in Peruvian population during social isolation by the COVID-19 pandemic

Huancahuire-Vega

Newball-Noriega

Rojas-Humpire

et al. 2021

Preprint

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“…According to recent reports in China and Singapore, 12.8% to 31.2% of COVID-19 patients had preexisting hypertension. 2,[17][18][19][20][21][22] These patients appeared to develop severe disease more frequently and were more susceptible to death. 2,19 Since a number of these patients used ARBs/ACEIs as antihypertensive drugs, which can increase the expression of ACE2, and because of the seemly paradoxical role of ACE2 during SARS-CoV-2 infection, we designed this retrospective study to determine whether the usage of ARBs/ACEIs are associated with SARS-CoV-2 infection and the clinical outcomes in COVID-19 patients with preexisting hypertension.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

Yang

Tan

Zhou

et al. 2020

Preprint

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With the capability of inducing elevated expression of ACE2, the cellular receptor for SARS-CoV-2, angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (ARBs/ACEIs) treatment may have a controversial role in both facilitating virus infection and reducing pathogenic inflammation. We aimed to evaluate the correlation of ARBs/ACEIs usage with the pathogenesis of COVID-19 in a retrospective, single-center study. 126 COVID-19 patients with preexisting hypertension at Hubei Provincial Hospital of TraditionalChinese Medicine (HPHTCM) in Wuhan from January 5 to February 22, 2020 were retrospectively allocated to ARBs/ACEIs group (n=43) and non-ARBs/ACEIs group (n=83) according to their antihypertensive medication. 125 age-and sex-matched COVID-19 patients without hypertension were randomly selected as non-hypertension controls. In addition, the medication history of 1942 hypertension patients that were admitted to HPHTCM from November 1 to December 31, 2019 before COVID-19 outbreak were also reviewed for external comparison. Epidemiological, demographic, clinical and laboratory data were collected, analyzed and compared between these groups. The frequency of ARBs/ACEIs usage in hypertension patients with or without COVID-19 were comparable.Among COVID-19 patients with hypertension, those received either ARBs/ACEIs or non-ARBs/ACEIs had comparable blood pressure. However, ARBs/ACEIs group had significantly lower concentrations of CRP (p=0.049) and procalcitonin (PCT, p=0.008).Furthermore, much lower proportion of critical patients (9.3% vs 22.9%; p=0.061), and a lower death rate (4.7% vs 13.3%; p=0.216) were observed in ARBs/ACEIs group than non-ARBs/ACEIs group, although these differences failed to reach statistical significance.All rights reserved. No reuse allowed without permission.(which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.Our findings thus support the use of ARBs/ACEIs in COVID-19 patients with preexisting hypertension.

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“…In the same vein, in a retrospective cohort of 124 patients in France, Simonnet et al found that obesity prevalence was high among patients admitted to the ICU (5). Although obesity is not as prevalent in China as in the Middle East, Peng et al obtained similar results in a retrospective analysis of 112 patients with COVID-19, who were admitted to Wuhan Union Hospital in Wuhan, China (6). When patients were divided into two groups according to the severity of the disease (critical and general), researchers observed that the BMI of the critical group was significantly higher than that of the general group (25.…”

Section: Discussionmentioning

confidence: 87%

COVID-19: Impact of Obesity and Diabetes in Disease Severity

Al-Sabah

Al‐Haddad

Youha

et al. 2020

Preprint

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Background: The Coronavirus disease 2019 (COVID19) pandemic is straining the healthcare system, particularly for patients with severe outcomes who require admittance to the intensive care unit (ICU). This study aimed to investigate the potential associations of obesity and diabetes with COVID19 severe outcomes, assessed as ICU admittance. Subjects: Demographic and patient characteristics from a retrospective cohort of 1158 patients hospitalized with COVID19 in a single center in Kuwait, along with their medical history, were analyzed. Univariate and multivariate analyses were performed to explore the associations between different variables and ICU admittance. Results: From the 1158 hospitalized patients, 271 (23.4%) had diabetes, 236 (20.4%) had hypertension and 104 (9%) required admittance into the ICU. From patients with available measurements, 157 (21.6%) had body mass index (BMI)≥25 kg/m2. Univariate analysis showed that overweight (BMI=25.0~29.9 kg/m2), obesity class I (BMI=30~34.9 kg/m2) and morbid obesity (BMI≥40 kg/m2) associated with ICU admittance (odds ratio (OR) [95% confidence intervals (CI)]: 2.45 [1.26~4.74] p value=0.008; OR [95% CI]: 3.51 [1.60~7.69] p value=0.002; and OR [95% CI]: 5.18 [1.50~17.85] p value=0.009], respectively). Patients with diabetes were more likely to be admitted to ICU (OR [95% CI]: 9.38 [5.49~16.02]). Two models for multivariate regression analysis were used, assessing either BMI or diabetes on ICU outcomes. In the BMI model, class I obesity and morbid obesity were associated with ICU admittance (adjusted OR (AOR) [95% CI]: 2.7 [1.17~6.20] p value=0.019 and AOR [95% CI]: 3.95 [1.00~15.20] p value=0.046, respectively). In the diabetes model, diabetes was associated with higher ICU admittance (AOR [95% CI]: 5.49 [3.13~9.65] p value<0.001) whereas hypertension had a protective effect on ICU admittance (AOR [95% CI]: 0.51 (0.28−0.91). Conclusions: In our cohort, overweight, obesity and diabetes in patients with COVID19 were associated with ICU admittance, putting these patients at higher risk of poor outcomes.

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Clinical Characteristics and Prognosis of 244 Cardiovascular Patients Suffering From Coronavirus Disease in Wuhan, China

Cited by 59 publications

References 26 publications

Changes in eating habits and lifestyles in Peruvian population during social isolation by the COVID-19 pandemic

Changes in eating habits and lifestyles in Peruvian population during social isolation by the COVID-19 pandemic

Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

COVID-19: Impact of Obesity and Diabetes in Disease Severity

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