Clinical characteristics and prognosis of polymyositis and dermatomyositis associated with malignancy: a 25-year retrospective study

Motomura, K.; Yamashita, Hiroyuki; Yamada, Shûzô; Takahashi, Yuko; Kaneko, Hiroshi

doi:10.1007/s00296-019-04428-z

Cited by 29 publications

(29 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, the mortality rate of CAM patients was 26.5%, which is significantly higher than non‐CAM patients (8.8%). This result was consistent with previous studies 11,17,20 . The main cause of death for CAM patients in this study was malignancy, so it may be reasonable to suggest that patients with initial risk factors be screened for malignancy in clinical practice.…”

Section: Discussionsupporting

confidence: 93%

Risk factors for cancer‐associated myositis: A large‐scale multicenter cohort study

Jia

Sun

et al. 2020

Int J of Rheum Dis

View full text Add to dashboard Cite

Aim: The aim of this study was to identify the risk factors and prognosis of patients with cancer-associated myositis (CAM). Method: Four hundred and eighty-seven patients with dermatomyositis (DM), clinical amyopathic dermatomyositis (CADM) and polymyositis (PM) from 3 clinical centers were enrolled retrospectively in this study. Clinical and laboratory data of CAM and non-CAM patients were compared. Logistic regression analysis was used to identify risk factors of CAM. Results: Out of the 487 patients with DM/CADM/PM, 7.0% (34/487) of patients were classified as CAM. Older age (53.91 ± 13.32 vs. 48.76 ± 14.34 years), heliotrope rash (61.8% vs. 41.9%), shawl sign (41.2% vs. 22.1%), V sign (58.8% vs. 38.6%) were observed significantly more commonly in patients with CAM than those without CAM (all P < .05). Fever (17.7% vs. 37.8%), arthralgia/arthritis (23.5% vs. 45.7%), interstitial lung disease (ILD, 38.2% vs 68.9%) were significantly less common in the CAM group than the non-CAM group. Age at onset (odds ratio [OR] 1.036, 95% CI 1.001-1.072, P = .042), shawl sign (OR 2.748, 95% CI 1.107-6.822, P = .029), anti-transition initiation factor (TIF)-1γ antibody (OR 4.012, 95% CI 1.268-12.687, P = .018) were identified as the initial risk factors for the onset of CAM, and ILD was identified as a protective factor for CAM (OR 0.292, 95% CI 0.115-0.739, P = .009). All-cause mortality was significantly higher in CAM patients compared with non-CAM patients (P = .001). Conclusion: The mortality of patients with CAM was higher than DM/CADM/PM patients without cancer. Malignancy should be screened in DM/CADM/PM patients especially with risk factors, including older age, shawl sign, anti-TIF-1γ antibody, and lack of ILD.

show abstract

Section: Discussionsupporting

confidence: 93%

Risk factors for cancer‐associated myositis: A large‐scale multicenter cohort study

Jia

Sun

et al. 2020

Int J of Rheum Dis

View full text Add to dashboard Cite

show abstract

“…Zinner syndrome is therefore rarely diagnosed at a younger age. 2 In this case, pelvic cystic structures in the male fetus were of an appropriate size to be observed during a routine obstetric scan. Coexisting unilateral renal agenesis was also strongly suggestive of the fetus having Zinner syndrome, which was eventually confirmed after birth.…”

Section: Prenatal Detection Of Zinner Syndromementioning

confidence: 72%

“…1 This rare syndrome is usually clinically silent until the age when the individual becomes sexually or reproductively active. 1,2 Diagnosis before infancy is very infrequent, much less prenatal detection. 3 Here we report a case of prenatally detected Zinner syndrome.…”

Section: Prenatal Detection Of Zinner Syndromementioning

confidence: 99%

“…In contrast, in the case of younger patients, multi-cystic dysplastic kidney (MCDK), not agenesis, was the more frequently associated renal malformation. 2 Different renal malformations based on the patient age group are considered in that renal agenesis may result from a former dysplastic kidney, most of which involute with time. Indeed, in the follow-up study on infants with prenatally diagnosed MCDK, persistent SVC was the most frequently encountered finding among the malformations of the ipsilateral internal genitalia, even if the MCDK had involuted.…”

Section: Prenatal Detection Of Zinner Syndromementioning

confidence: 99%

“…The majority of malignancies are diagnosed within a mean of 1 year of a diagnosis of DM/PM. 2 No patient has been reported with lymphoma before the clinical onset of DM/PM in children. 3 High inflammatory activity in patients with autoimmune disease is considered the major risk factor for developing lymphoma.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Paraneoplastic dermatomyositis with pediatric Hodgkin lymphoma: A case report

Suzuki

Koto

Tanaka

et al. 2020

Pediatrics International

View full text Add to dashboard Cite

Dermatomyositis (DM) and polymyositis (PM) are autoimmune myopathies and their association with malignancies is well known in adults. However, DM/PM is an uncommon complication of Hodgkin lymphoma (HL), especially in children. An 11-year-old girl presented with deteriorating symmetrical muscle weakness, proximal limb myalgia, and persistent fever, followed by axillary and cervical lymphadenopathy for 2 months. She had no family history of autoimmune disease nor malignancy. Axillary lymph node biopsy revealed mixed cellularity classic HL (Fig. S1); her creatine kinase (CK) level was normal at the time of biopsy. On admission, she could not move due to severe pain with generalized non-pitting edema. She had developed a heliotrope rash but not Gottron papules. She did not complain of dysphasia nor dyspnea. Hematological findings showed elevated levels of CK (5250 IU/L), aldolase (31.9 U/L), lactate dehydrogenase (762 IU/L), C-reactive protein (11.4 mg/dL), and soluble interleukin-2 receptor (2407 U/mL), with leukocytosis (25 9 10 9 /L) and microcytic anemia (hemoglobin 8.9 g/dL). Epstein-Barr virus titer showed the presence of a nuclear antigen (1 : 10) and viral capsid antigen IgG (1 : 40), while the viral DNA load was undetectable. 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) (Fig.1a) and magnetic resonance imaging (Fig. 1b) showed abnormal diffuse accumulation in the muscles of all extremities, along with a finding of supradiaphragmatic lymphadenopathy, including infiltration of the mediastinal lymph nodes externally (Fig.1c). There was no comorbid interstitial lung disease and no evidence of metastasis to the bone marrow; muscle biopsy was difficult to perform. Clinical findings in addition to myopathic changes on electromyography confirmed a clinical diagnosis of DM, according to Bohan and Peter criteria. Serology was negative for anti-transcriptional intermediary factor 1 c (anti-TIF1c), anti-melanoma differentiation-associated gene 5 (anti-MDA5), anti-histidyl transfer RNA [t-RNA] synthetase (anti-JO-1),

show abstract

Anti‐nuclear matrix protein 2 antibody‐positive amyopathic dermatomyositis presenting in a patient with prostate cancer: A case report

Shan,

Gupta,

Ortega‐Loayza

et al. 2024

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessageNuclear matrix protein (NXP‐2) positive amyopathic dermatomyositis (DM) may present without classic symptoms like muscle weakness, dysphagia, and edema, and mimic conditions like cutaneous lupus. Given DM's association with malignancy and interstitial lung disease, prompt and accurate diagnosis is important. Testing for myositis‐specific antibodies aids diagnosis in ambiguous cases.

show abstract

Clinical characteristics and prognosis of polymyositis and dermatomyositis associated with malignancy: a 25-year retrospective study

Cited by 29 publications

References 23 publications

Risk factors for cancer‐associated myositis: A large‐scale multicenter cohort study

Risk factors for cancer‐associated myositis: A large‐scale multicenter cohort study

Paraneoplastic dermatomyositis with pediatric Hodgkin lymphoma: A case report

Anti‐nuclear matrix protein 2 antibody‐positive amyopathic dermatomyositis presenting in a patient with prostate cancer: A case report

Contact Info

Product

Resources

About