Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Yu, Xiaoyan; Liang, Xiaoxiang; Kong, Wen

doi:10.3892/ol.2022.13573

Cited by 8 publications

(3 citation statements)

References 118 publications

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“…13 There have been rare reports of GIST metastasizing to the ovary. [14][15][16][17] From our study, we found a case of metastasis of GIST to the left ovary. This was in a 54-year-old woman.…”

Section: Discussionmentioning

confidence: 65%

Gross architecture of ovarian specimens from a southwest Nigerian tertiary healthcare facility

Olaofe,

Okongwu,

Ewoye

et al. 2024

Int J Reprod Contracept Obstet Gynecol

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Background: The aim of our study is to describe the gross morphology of ovarian specimens and to see if some entities can be distinguished based on their gross morphology. Methods: We did a cross-sectional study of all ovarian specimen received by the department of morbid anatomy and forensic medicine of Obafemi Awolowo university teaching hospitals complex (OAUTHC), Ile-Ife, Nigeria from January 1, 2018, to December 31, 2022 (Five-year period). OAUTHC is situated in the southwestern part of Nigeria. Results: We examined 225 right ovarian specimens. Non- neoplastic lesions were the most common lesions of the right ovary accounting for 52 cases followed by malignant tumour accounting for 25 cases. We examined 233 specimens of the left ovary of which 133 were normal. Eighteen (72%) of malignant tumors of the left ovary had cystic cut surfaces. The spectrum of lesions of both ovaries has different average widest diameters with significant overlap in their distribution. Metastatic carcinoma is seen to involve both ovaries and found to mainly have a solid cut surface. We found that the average widest diameter of a normal left ovary is 3.6 cm while that of a normal right ovary is 4.9 cm. Conclusions: The ovarian lesions have different widest diameters and are usually larger than that of a normal ovary. Benign ovarian tumours are generally larger than their malignant counterparts but cannot be distinguished based on size alone. Metastatic carcinoma involved both ovaries and had a predominantly solid-cut surface. The normal left ovaries were smaller than the normal right ovaries.

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Section: Discussionmentioning

confidence: 65%

Gross architecture of ovarian specimens from a southwest Nigerian tertiary healthcare facility

Olaofe,

Okongwu,

Ewoye

et al. 2024

Int J Reprod Contracept Obstet Gynecol

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“…Extragastrointestinal stromal tumor (eGIST) is extremely rare. Metastasis is common in advanced GIST which usually metastasized to liver (50-65%) and peritoneum (20-43%), and less frequently to lymph node (< 6%), bone (< 6%) and lung (< 2%), with other sites relatively rare [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers

Chen

Yang

et al. 2023

Mol Cancer

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Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human health and economy globally. Curative surgical resections and tyrosine kinase inhibitors (TKIs) are the main managements for localized GISTs and recurrent/metastatic GISTs, respectively. Despite multi-lines of TKIs treatments prolonged the survival time of recurrent/metastatic GISTs by delaying the relapse and metastasis of the tumor, drug resistance developed quickly and inevitably, and became the huge obstacle for stopping disease progression. Immunotherapy, which is typically represented by immune checkpoint inhibitors (ICIs), has achieved great success in several solid tumors by reactivating the host immune system, and been proposed as an alternative choice for GIST treatment. Substantial efforts have been devoted to the research of immunology and immunotherapy for GIST, and great achievements have been made. Generally, the intratumoral immune cell level and the immune-related gene expressions are influenced by metastasis status, anatomical locations, driver gene mutations of the tumor, and modulated by imatinib therapy. Systemic inflammatory biomarkers are regarded as prognostic indicators of GIST and closely associated with its clinicopathological features. The efficacy of immunotherapy strategies for GIST has been widely explored in pre-clinical cell and mouse models and clinical experiments in human, and some patients did benefit from ICIs. This review comprehensively summarizes the up-to-date advancements of immunology, immunotherapy and research models for GIST, and provides new insights and perspectives for future studies.

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“…Частина СПШКТ має доброякісний характер. Можливе метастазування СПШКТ у печінку і очеревину, рідше до м'яких тканин або до кісток, та до легень [9,10]. Казуїстикою є метастазування у лімфатичні вузли (за винятком дитячих СПШКТ та при синдромі Карні-Стратакіса) [6,11].…”

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Gastrointestinal Stromal Tumors. Course Prediction and Diagnostic Algorithms

Ilyina-Stognienko,

Khimich

2024

CAOS

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The purpose of the review is to compare modern algorithms for predicting the course of GIST.Material and methods. An information search was conducted using the PubMed, OVID, EMBASE, SRC BOLD databases using keywords that corresponded to the MESH terms «gastro-i ntestinal stromal tumors» AND «prognosis» AND «diagnosis». The search depth is 10 years. From the total array of 66 publications, 20, most relevant to the search subject, were selected. Information analysis was carried out in accordance with the PRISMA criteria.The results. A comparison of various medical imaging methods and models for predicting clinical outcomes in GIST was carried out. The main prognostic criteria are the size of the tumor, its localization and mitotic index. Criteria for assessing the response to treatment during MRI and PET were revised. The diﬀ erences, advantages, and limitations of various prognosticators are discussed Conclusions. Gastrointestinal stromal tumors are a rare pathology, which, however, often has a progressive course. Existing models for predicting the course of GIST do not take into account genetic variants. The use of a multidisciplinary approach has signiﬁ cant prospects in the selection of SPSHKT therapy.

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Clinical characteristics and prognosis of gastrointestinal stromal tumors with rare site metastasis (Review)

Cited by 8 publications

References 118 publications

Gross architecture of ovarian specimens from a southwest Nigerian tertiary healthcare facility

Gross architecture of ovarian specimens from a southwest Nigerian tertiary healthcare facility

Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers

Gastrointestinal Stromal Tumors. Course Prediction and Diagnostic Algorithms

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