Clinical characteristics and prevalence of biofilm producing Enterococcus spp. from January 2017 until December 2017 in Hospital Sungai Buloh

Abstract

Methods and materials: This is an unmatched case-control study where the children of either sex, aged 0-59 months with the history of cough or difficult breathing and radiologic pneumonia were enrolled. The children who were assessed for sepsis (n = 123) at admission were the study population. Children those without sepsis (n = 82) were the controls. Comparison was made between children with clinically defined sepsis and without sepsis.Results: Bacterial growth on blood culture was found in 19% patients, however, 7% patients did not show any bacterial growth. Among them 8% of bacterial isolates was coagulase-negative staphylococci which is followed by Acinetobacter species (2.4%). Only 1.7% cases were infected with Streptococcus pneumonia, Haemophylus influenza, Salmonella typhi and Klebsiella. In contrast with that, children without sepsis presented 2.4% growth of Salmonella typhi, 1.2% of Klebsiella and no growth of Streptococcus pneumonia and Haemophylus influenza was obtained. Species of E. coli (0.8%) and Enterococcus (0.8%) were also obtained in the cultures. Among them 100% sensitivity was obtained for imipenem, 87% for meropenem, 84% for ceftazidime, 77% for ciprofloxacin, 71% for both netilmicin and amikacin and 52% for gentamicin. The mortality rate (odds ratio [OR] = 3.02, 95% confidence interval [CI], 1.11-8.64, p < 0.027) is high among the children with sepsis.Conclusion: Laboratory characteristics in these children will help to have early diagnosis and treatment that will help to reduce mortality.