Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational study

Cosentino, Federica; Moscatt, Vittoria; Marino, Andrea; Pampaloni, Alessio; Scuderi, Daniele; Ceccarelli, Manuela; Benanti, F.; Gussio, Maria; Larocca, Licia; Boscia, Vincenzo; Vinci, G; Zagami, Aldo; Onorante, Anna; Lupo, Gaetano; Torrisi, Salvatore; Grasso, Silvana; Bruno, Roberto; Iacobello, Carmelo; Bonfante, Salvatore; Guarneri, L.; Franco, Antonella Di; Vecchio, R; Rosolini, Maria Di; Pulvirenti, Alfredo; Larnè, Damiano; Nunnari, Giuseppe; Celesia, Benedetto Maurizio; Cacopardo, Bruno

doi:10.3892/br.2022.1517

Cited by 24 publications

(18 citation statements)

References 33 publications

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“…Sputum production in patients with COVID-19 is rarely observed (<1%) and is an important indicator for differentiating between viral and bacterial pneumonia. Sputum production in severe cases is often caused by secondary bacterial infection (20,21). Diarrhea was more frequently observed in severe COVID-19 cases than in non-severe cases while nausea was more frequent in non-severe cases as compared to severe cases.…”

Section: Discussionmentioning

confidence: 98%

Clinical characteristics among patients with COVID‑19: A single‑center retrospective study

et al. 2022

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Section: Discussionmentioning

confidence: 98%

Clinical characteristics among patients with COVID‑19: A single‑center retrospective study

et al. 2022

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“…Overall, although the patient that we presented had no relevant immunosuppression diseases [ 33 , 49 , 50 , 51 ], except for cancer diagnosis, she presumably died due to disseminated intravascular coagulation (CID)-like syndrome caused by septic shock. Despite the SARS-CoV2 infection, the patients did not have any lung involvement; however, we could not definitely rule out viral effects such as hyperinflammation and hypercoagulopathy [ 52 , 53 , 54 ]. Therefore, it is hard to define whether the antibiotic therapy had sufficient time to be effective, or whether the multi-organ failure, caused by bacterial and viral co-infection, led to the exitus before or notwithstanding the opportune therapy [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium striatum Bacteremia during SARS-CoV2 Infection: Case Report, Literature Review, and Clinical Considerations

Marino

Campanella

Stracquadanio

et al. 2022

Infectious Disease Reports

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Bacterial infections, especially those in hospital settings, represent a major complication of COVID-19 patients, complicating management and worsening clinical outcomes. Corynebacterium striatum is a non-diphtheric actinobacterium that has been reported as being the causative agent of several different infections, affecting both immunocompetent and immunocompromised patients. Recently, C. striatum has been recognized as a nosocomial pathogen that is responsible for severe infection in critical patients, as well as in fragile and immunocompromised subjects. C. striatum has been described as the etiological agent of bacteremia, central line infections, and endocarditis. We report a case of a 91-year-old woman who was hospitalized due to SARS-CoV-2 infection, who developed C. striatum bacteremia and died despite antimicrobial therapy and clinical efforts. Furthermore, we discuss C. striatum diagnosis and treatment based on evidence from the scientific literature.

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“…Older individuals are at an increased risk for complications and death due to COVID-19 [ 3 , 14 , 15 , 16 , 17 ]. This increased risk may be associated with several changes that come with age such as decreased mucociliary clearance of the respiratory tract, hormonal changes such as a reduction in the testosterone levels in older men, and immunological changes that may affect the patient’s ability to clear the virus [ 4 , 5 , 6 , 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 in Older Individuals Requiring Hospitalization

Ιωάννου

Spentzouri²,

Konidaki³

et al. 2022

Infectious Disease Reports

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Older individuals have an increased risk for severe coronavirus disease 2019 (COVID-19) and a higher risk for complications and death. The aim of this study was to investigate the clinical characteristics of older patients admitted with COVID-19 and describe their outcomes. This was a retrospective cohort study of patients older than 65 years admitted to the COVID-19 Department of the University Hospital of Heraklion. Data recorded and evaluated included age, gender, Infectious Diseases Society of America (IDSA) severity score, Charlson comorbidity index (CCI), high-flow nasal oxygen (HFNO) use, admission to the Intensive Care Unit (ICU), laboratory exams, treatment administered, and outcome. In total, 224 patients were evaluated in the present study. The median age was 75 years and 105 (46.9%) were female. In 50 patients (22.7%), HFNO was used and 23 (10.3%) were admitted to the ICU. Mortality was 13.4% (30 patients). Patients that died had higher age, were more likely to be male, had an IDSA severity score of 3, had prior HFNO use, had been admitted to the ICU, and were also more likely to have a higher white blood cell (WBC) count, CRP, ferritin, procalcitonin, d-dimers, and troponin. A multivariate logistic regression analysis identified age and the need for HFNO use to be independently positively associated with mortality. To conclude, COVID-19 carries significant mortality in hospitalized older patients, which increases with age, while the need for HFNO also increased the likelihood of worse outcomes. Clinicians caring for patients with COVID-19 should bear in mind these two factors. Future studies could elaborate on the effect of new variants on the dynamics of mortality in older patients.

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Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational study

Cited by 24 publications

References 33 publications

Clinical characteristics among patients with COVID‑19: A single‑center retrospective study

Clinical characteristics among patients with COVID‑19: A single‑center retrospective study

Corynebacterium striatum Bacteremia during SARS-CoV2 Infection: Case Report, Literature Review, and Clinical Considerations

COVID-19 in Older Individuals Requiring Hospitalization

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