Clinical Characteristics and Outcomes of Patients With Heart Failure and Methamphetamine Abuse

Thomas, Isac C.; Nishimura, Marin; Ma, Janet; Dickson, Stephen; Alshawabkeh, Laith; Adler, Eric; Maisel, Alan S.; Criqui, Michael H.; Greenberg, Barry

doi:10.1016/j.cardfail.2019.10.002

Cited by 32 publications

(45 citation statements)

References 17 publications

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“…However, patients with methamphetamine-associated cardiomyopathy were less likely to have atrial fibrillation versus those with cardiomyopathy due to other causes (adjusting for comorbidities). 94 This inverse association between atrial fibrillation and methamphetamine use in cardiomyopathy patients was corroborated by a large Veterans Administration study. Patients with methamphetamine-associated cardiomyopathy, however, were ≈10-years younger.…”

Section: Substituted Amphetamines and Atrial Arrhythmiasmentioning

confidence: 81%

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Dominic

Ahmad

Awwab

et al. 2022

Circ: Arrhythmia and Electrophysiology

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Nonmedical use of prescription and nonprescription drugs is a worldwide epidemic, rapidly growing in magnitude with deaths because of overdose and chronic use. A vast majority of these drugs are stimulants that have various effects on the cardiovascular system including the cardiac rhythm. Drugs, like cocaine and methamphetamine, have measured effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias. Substituted amphetamines and cocaine affect the expression and activation kinetics of multiple ion channels and calcium signaling proteins resulting in EKG changes, and atrial and ventricular brady and tachyarrhythmias. Preexisting conditions cause substrate changes in the heart, which decrease the threshold for such drug-induced cardiac arrhythmias. The treatment of cardiac arrhythmias in patients who take drugs of abuse may be specialized and will require an understanding of the unique underlying mechanisms and necessitates a multidisciplinary approach. The use of primary or secondary prevention defibrillators in drug abusers with chronic systolic heart failure is both sensitive and controversial. This review provides a broad overview of cardiac arrhythmias associated with stimulant substance abuse and their management.

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Section: Substituted Amphetamines and Atrial Arrhythmiasmentioning

confidence: 81%

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Dominic

Ahmad

Awwab

et al. 2022

Circ: Arrhythmia and Electrophysiology

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“…Furthermore, the damage to physical health from MA abuse is reflected in the increasing deterioration of physical function, cardiorespiratory and cardiovascular function, and all of its related physical indicators. Long-term use of MA has deleterious effects on motor function and muscles (10), causes excessive pulmonary stress (11), increases vascular damage, leads to persistent vascular dysfunction, and accelerates atherosclerosis (12)(13)(14). Finally, among psychological conditions, depression and anxiety are the most common disorders (15), and depression has been recognized as a hallmark of MA withdrawal symptoms (16), which may be because of abnormalities in monoamine neurotransmitter pathways, such as dopamine, serotonin, and norepinephrine, as a result of MA abuse (17,18).…”

Section: Introductionmentioning

confidence: 99%

Effects of moderate-intensity exercise on social health and physical and mental health of methamphetamine-dependent individuals: A randomized controlled trial

Zhu

Liang

et al. 2022

Front. Psychiatry

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ObjectiveMethamphetamine (MA)-dependent individuals’ health problems are widespread and need to be solved urgently. Exercise is considered a potential treatment for MA dependents. The study aimed to determine the effects of a 12-week aerobic exercise on the social, physical, and mental health of MA-dependent individuals.Materials and methodsSixty MA-dependent individuals were randomly assigned into two groups. Subjects in the exercise group (n = 30) received an exercise intervention five days a week for 60 min each for 12 weeks. Subjects in the control group (n = 30) received regular corrective rehabilitation without exercise in the same setting. Outcome measures, including questionnaires [quality of life scale for drug addiction (QOL-DA), self-rating anxiety scale (SAS), self-rating depression scale (SDS), and Pittsburgh sleep quality index (PSQI)] and physical fitness, were arranged the day before the start of the intervention and the day after the end of the intervention. Two-factor repeated measures ANOVA was used to compare the treatment differences between the two groups.ResultsAfter 12 weeks of the intervention period, social health was significantly improved in the exercise group (P < 0.01), and there was a statistically significant difference in mental health scores between exercise group and control group, with a greater impact in exercise group.(Psychology: P < 0.01; SAS: P < 0.01; SDS: P < 0.01; PSQI: P < 0.01), physical health improved in the exercise group, physiology (P < 0.01), symptom (P < 0.01), heart rate (P < 0.01), systolic blood pressure (P < 0.01), systolic blood pressure (P < 0.01), vital capacity (P < 0.05), grip (P < 0.01), vertical jump (P < 0.001), sit and reach (P < 0.01), 50-meter run (P < 0.01), and reaction time (P < 0.01).ConclusionAerobic exercise intervention is an effective treatment for MA-dependent individuals, and the 12-week intervention improved the social, physical, and mental health of MA-dependent individuals. We recommend that future studies focus more on drug-dependent individuals’ overall health status rather than just relapse.Clinical trial registration: [https://www.chictr.org.cn/hvshowproject.aspx?id=131048], identifier [ChiCTR2200055348].

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Section: Introductionmentioning

confidence: 99%

“…In addition, a 12-fold increase in the number of annual hospitalizations due to heart failure (HF) secondary to methamphetamine use from 2002 to 2014 (547 to 6625, +1111%; P<0.0001) was observed [5]. The prevalence of heart failure due to methamphetamine increased from 2.5 cases per 1000 in 2010 to 7.4 cases per 1000 in 2014 (P<0.0001) [5]. Thomas et al found that in patients using marijuana and methamphetamine concomitantly, there was approximately a 20-fold increase in the diagnosis of methamphetamine-associated heart failure [5].…”

Section: Introductionmentioning

confidence: 99%

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Case Report Highlighting Cardiovascular Effects of Concomitant Use of Methamphetamine and Marijuana

Fontana¹,

Panahi²,

Udeani³

et al. 2022

Cureus

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We present the case of a 51-year-old male admitted for cardiovascular complications in the face of concomitant chronic methamphetamine and cannabis use. Upon further assessment, the patient exhibited cardiotoxicity, including acute to chronic congestive heart failure (CHF) exacerbation, hypercoagulable state, and electrolyte abnormalities. Cardiotoxicity secondary to chronic methamphetamine use has been established. However, marijuana's cardiovascular effects have not been well established. Even less information exists about the simultaneous use of methamphetamine and cannabis. With increasing interest in the use of marijuana for medical purposes, it is imperative to study any corresponding toxicity and adverse effect profile. The worldwide pattern of drug co-administration also brings the importance of this topic to light. This case report serves to provide insight into this information gap.

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Clinical Characteristics and Outcomes of Patients With Heart Failure and Methamphetamine Abuse

Cited by 32 publications

References 17 publications

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Stimulant Drugs of Abuse and Cardiac Arrhythmias

Effects of moderate-intensity exercise on social health and physical and mental health of methamphetamine-dependent individuals: A randomized controlled trial

Case Report Highlighting Cardiovascular Effects of Concomitant Use of Methamphetamine and Marijuana

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