2018
DOI: 10.1371/journal.pone.0209352
|View full text |Cite
|
Sign up to set email alerts
|

Clinical characteristics and outcomes of primary sclerosing cholangitis and ulcerative colitis in Japanese patients

Abstract: BackgroundIn Western countries, most patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). The number of patients with UC in East Asia has increased markedly over the past two decades. However, current clinical features of PSC and of PSC associated with UC (PSC-UC) have not yet been clarified in East Asia, particularly in Japan. We aimed to reveal the clinical courses and associations with UC in Japanese patients with PSC from the mutual viewpoint of PSC and UC.MethodsWe r… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
20
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 24 publications
(21 citation statements)
references
References 40 publications
1
20
0
Order By: Relevance
“…Part of the significance of diagnosing and treating IBD associated with PSC comes from the fact that patients with IBD are at an increased risk of developing colorectal cancer (CRC). CRC has been identified as a significant prognostic factor for PSC [ 13 ], although it remains to be determined whether the coexistence of IBD has an impact on the prognosis of PSC [ 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…Part of the significance of diagnosing and treating IBD associated with PSC comes from the fact that patients with IBD are at an increased risk of developing colorectal cancer (CRC). CRC has been identified as a significant prognostic factor for PSC [ 13 ], although it remains to be determined whether the coexistence of IBD has an impact on the prognosis of PSC [ 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…UC is a well-recognized complication of PSC. The current comorbidity rate of UC for patients with PSC in Japan ranges from approximately 20% to 55%, which is lower than the range of 30% to 80% for Western cohorts [ 1 4 ]. Although UC is also recognized as a risk factor for the development of dysplasia or cancer [ 5 8 ], we rarely encounter a patient with PSC-related UC and concurrent colon cancer requiring both LT and colectomy, as in the current case.…”
Section: Discussionmentioning
confidence: 99%
“…Primary sclerosing cholangitis (PSC) is one of the most common indications for liver transplantation (LT) and is a well-known complication of ulcerative colitis (UC) because of the associated autoimmune characteristics [ 1 4 ]. UC is a well-recognized risk factor for colon cancer [ 5 8 ]; therefore, we occasionally encounter a complicated situation in which a patient with PSC develops concurrent UC-related colon cancer.…”
Section: Introductionmentioning
confidence: 99%
“…PSC is usually diagnosed by MRI imaging of the biliary tree to identify cholestasis and/or strictures ( 69 , 91 , 92 ). Up to 80% of PSC patients also present with inflammatory bowel disease (IBD), indicating a general gastrointestinal inflammatory phenotype ( 93 ). Taken alongside the fact that PSC is more common in men and has less strong HLA associations, the lack of known autoantibodies calls into question whether the disease is strictly autoimmune, or whether it is autoinflammatory in nature ( 94 ).…”
Section: Autoantigens and Autoantibodiesmentioning
confidence: 99%