Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis

Eledrisi, Mohsen; Alkabbani, Haifaa; Aboawon, Malk; Ali, Amjad; Alabdulrazzak, Imad; Elhaj, Maab F; Ahmed, Ashraf Uddin; Alqahwachi, Hazim; Daghfal, Joanne; Beshyah, Salem A; Malik, Rayaz A.

doi:10.1016/j.diabres.2022.110041

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…In our initial evaluation, we examined age, BMI, glucose metabolism, and markers of bone turnover between patients with type diabetes and those with diabetic ketoacidosis. The data demonstrate differences in glucose and bone metabolism in DKA, sug-gesting that individuals prone to or affected by DKA are often younger, have lower BMI, exhibit poor glycemic control, and experience diminished pancreatic function [11][12][13]. Regarding bone turnover status, it was observed that the calcium level may decrease due to acidosis and negative nitrogen balance [14].…”

Section: Multilinementioning

confidence: 90%

The Evolution of the Bone Turnover Marker in Patients Following Recovery from Diabetic Ketoacidosis

Wen,

Xu,

Yuan

et al. 2024

Horm Metab Res

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The aim of the study was to investigate whether the biomarkers for bone turnover could rapidly recover during the period of diabetic ketoacidosis (DKA). Bone turnover biomarkers, including 25-hydroxyvitamin D3, N-terminal middle molecular fragment of osteocalcin (NMID), and β-C terminal cross-linking telopeptide of type 1 collagen were evaluated using in-patient data (n=627) from Shanghai Pudong Hospital from 2018–2022. The comparison was performed between type 2 diabetes (T2D only) (n=602) and DKA (n=25), in which we checked the bone turnover markers at pre-treatment and recovery. After matching by body mass index (BMI), we found that except for 25-OH-VitD3, the age difference, indices of glucose metabolism, and bone turnover were significant between the 2 groups (p<0.05). We found only a significant restoration of NMID (p<0.001). NMID and β-CTX, when compared with T2D, showed overt distinction between recovery and T2D (p<0.05). In addition, the investigations demonstrated a substantial difference between 25-OH-VitD3 in males and NMID in females, regardless of age (p<0.05). Multilinear regression analysis revealed that 2 hours postprandial plasma C-peptide was an independent predictor of the NMID in both pre-treatment (β=0.58, p=0.003) and recovery (β=0.447, p=0.025), although sex was significant in pre-treatment (β=–0.444, p=0.020). Finally, we found that only age variation affected DKA’s fasting plasma glucose level (p<0.05). The study revealed that the bone turnover of DKA is significantly different in pre-treatment and recovery; however, NMID might recover quickly if the patients received appropriate treatment. Importantly, pancreatic function plays a critical role in changing bone turnover biomarkers.

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Section: Multilinementioning

confidence: 90%

The Evolution of the Bone Turnover Marker in Patients Following Recovery from Diabetic Ketoacidosis

Wen,

Xu,

Yuan

et al. 2024

Horm Metab Res

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“…The competence of clinicians in monitoring DKA management constitutes a critical evaluation. A national cohort in Qatar ( n = 602 in T1D; n = 1011 in T2D) reported a lower admission to the intensive care unit (26.6.% vs. 38.0%), shorter hospital stays (2 days vs. 5 days), and lower inpatient mortality in T1D (1.0% vs. 7.4%) compared to T2D [ 124 ]. Correspondingly, another nationwide study in Japan ( n = 10,442 in T1D; n = 13,835 in T2D) showed a lower in-hospital mortality in T1D (0.9% vs. 4.3% in T2D) [ 125 ].…”

Section: Future Directions For Obesity Management In Type 1 Diabetesmentioning

confidence: 99%

The emergence of obesity in type 1 diabetes

Kueh,

Chew,

Al-Ozairi

et al. 2023

Int J Obes

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Obesity, a chronic low-grade inflammatory disease represented by multifactorial metabolic dysfunctions, is a significant global health threat for adults and children. The once-held belief that type 1 diabetes is a disease of people who are lean no longer holds. The mounting epidemiological data now establishes the connection between type 1 diabetes and the subsequent development of obesity, or vice versa. Beyond the consequences of the influx of an obesogenic environment, type 1 diabetes-specific biopsychosocial burden further exacerbates obesity. In the course of obesity management discussions, recurring challenges surfaced. The interplay between weight gain and escalating insulin dependence creates a vicious cycle from which patients struggle to break free. In the absence of weight management guidelines and regulatory approval for this population, healthcare professionals must navigate the delicate balance between benefits and risks. The gravity of this circumstance highlights the importance of bringing these topics to the forefront. In this Review, we discuss the changing trends and the biopsychosocial aspects of the intersection between type 1 diabetes and obesity. We highlight the evidence supporting the therapeutic means (i.e., exercise therapy, nutritional therapy, adjunct pharmacotherapy, and bariatric surgery) and directions for establishing a more robust and safer evidence-based approach.

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Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis

Cited by 2 publications

References 46 publications

The Evolution of the Bone Turnover Marker in Patients Following Recovery from Diabetic Ketoacidosis

The Evolution of the Bone Turnover Marker in Patients Following Recovery from Diabetic Ketoacidosis

The emergence of obesity in type 1 diabetes

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