Clinical Characteristics And Outcomes Of Sepsis-Related Vs. Non-Sepsis-Related Acute Respiratory Distress Syndrome

許超群,; Sheu, Chau‐Chyun; Gong, Ming; Zhai, Rihong; Chen, F; Bajwa, EK; Pf, Clardy; Dc, Gallagher; Bt, Thompson; Dc, Christiani

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2592

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“…In a recent prospective cohort study including 2768 patients comparing the clinical characteristics and outcomes of sepsis-related versus nonsepsis-related ARDS, the authors report a mortality rate of 22.6% in the latter group. 24 In light of the fact that our patient sample includes patients with ARDS as well as those who were coded as RI and therefore less acutely ill, our findings appear to be consistent with the published literature in the nontrauma surgical patient population.…”

Section: Discussionsupporting

confidence: 87%

Mortality of Patients With Respiratory Insufficiency and Adult Respiratory Distress Syndrome After Surgery

Memtsoudis

Bombardieri

et al. 2011

J Intensive Care Med

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Section: Discussionsupporting

confidence: 87%

Mortality of Patients With Respiratory Insufficiency and Adult Respiratory Distress Syndrome After Surgery

Memtsoudis

Bombardieri

et al. 2011

J Intensive Care Med

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“…6,7 Sepsis-related ARDS has a higher overall disease severity, poorer recovery from lung injury, and higher mortality than non-sepsis-related ARDS. 8 As part of the therapy for the underlying disease, patients with ARDS invariably require mechanical ventilation to decrease the work of breathing and to improve oxygen transport. An improvement in Transfusion of blood products Reperfusion pulmonary edema oxygenation can be obtained in many ARDS patients by an increase in PEEP, a strategy that was originally suggested by Ashbaugh et al 1 Since it is difficult to measure changes in capillary and alveolar permeability at the bedside, diagnosis of ARDS is based on a combination of clinical, oxygenation, hemodynamic, and radiographic criteria.…”

Section: The Typical Ards Patientmentioning

confidence: 99%

What Is the Acute Respiratory Distress Syndrome?

Villar

2011

Respir Care

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It has been known for decades that shock and sepsis can cause a syndrome of acute respiratory failure with characteristics of non-cardiogenic pulmonary edema. Over the years, this syndrome has been given a number of names, including congestive atelectasis, traumatic wet lung, and shock lung. In 1967 the modern counterpart to this syndrome was described and subsequently called the "acute respiratory distress syndrome" (ARDS). This syndrome results from lung injury and inflammation. As with inflammation elsewhere, ARDS is accompanied by many cellular and molecular processes, some of them specific to the syndrome, others perpetuating the syndrome, and others inactivating the by-products of inflammation. Since no specific clinical sign or diagnostic test has yet been described that identifies ARDS, its diagnosis is based on a constellation of clinical, hemodynamic, and oxygenation criteria. Current ARDS treatment is mainly supportive, since these patients frequently have coexisting conditions. Although in 1994 a new standard ARDS definition was accepted, that definition failed to standardize the measurement of the oxygenation defect and does not recognize different severities of pulmonary dysfunction. Based on current evidence there is a need for a better definition and classification system that could help us to identify ARDS patients who would be most responsive to supportive therapies and those unlikely to benefit because of the severity of their disease process. This paper examines our current understanding of ARDS and discusses why the current definition may not be the most appropriate for research and clinical practice.

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Clinical Characteristics And Outcomes Of Sepsis-Related Vs. Non-Sepsis-Related Acute Respiratory Distress Syndrome

Cited by 2 publications

References 0 publications

Mortality of Patients With Respiratory Insufficiency and Adult Respiratory Distress Syndrome After Surgery

Mortality of Patients With Respiratory Insufficiency and Adult Respiratory Distress Syndrome After Surgery

What Is the Acute Respiratory Distress Syndrome?

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