Clinical characteristics and outcomes of 56 patients with pneumonia caused by carbapenem-resistant Klebsiella pneumoniae

Chen, I-Ren; Huang, Po‐Han; Wu, Ping; Wang, Fu‐Der; Lin, Yi-Tsung

doi:10.1016/j.jgar.2021.03.028

Cited by 6 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, carbapenemase-producing K. pneumoniae was isolated in 1996, [ 22 ] and the strain is becoming a highly threatening pathogen, especially in a nosocomial setting. [ 23 ] Treatment options are extremely limited for these resistant strains, and infected patients have a higher mortality than those with a nonresistant strain. [ 24 ] At our institute, screening for such resistance was not routinely performed, so it is unknown whether these potentially resistant strains affect disease progression.…”

Section: Discussionmentioning

confidence: 99%

Radiological patterns and prognosis in elderly patients with acute Klebsiella pneumoniae pneumonia: A retrospective study

et al. 2022

View full text Add to dashboard Cite

Although Klebsiella pneumoniae pneumonia is an insidious threat among the elderly, the role of radiological features has not been elucidated. We aimed to evaluate thin-section chest computed tomography (CT) features and assess its associations with disease prognosis in elderly patients with acute K. pneumoniae pneumonia. We retrospectively included elderly patients, admitted for acute K. pneumoniae pneumonia, and investigated thin-section CT findings to determine whether bronchopneumonia or lobar pneumonia was present. The association between the radiological pattern of pneumonia and in-hospital mortality was analyzed. Eighty-six patients with acute K. pneumoniae pneumonia were included, and among them, the bronchopneumonia pattern was observed in 70 (81%) patients. Twenty-five (29%) patients died in hospital, and they had a greater incidence of lobar pneumonia pattern (40% in nonsurvivors vs 10% in survivors; P = .008), low albumin level (2.7 g/dL, range, 1.6–3.8 in nonsurvivors vs 3.0 g/dL, range, 1.7–4.2 in survivors; P = .026) and higher levels of aspartate aminotransferase (30 U/L, range, 11–186 in nonsurvivors vs 23 U/L, range, 11–102 in survivors, P = .017) and C-reactive protein (8.0 mg/dL, range, 0.9–26.5 in nonsurvivors vs 4.7 mg/dL, range, 0.0–24.0 in survivors; P = .047) on admission. Multivariate analysis showed that lobar pneumonia pattern was independently associated with increased in-hospital mortality (adjusted hazard ratio, 3.906; 95% CI, 1.513–10.079; P = .005). In elderly patients with acute K. pneumoniae pneumonia, the lobar pneumonia pattern may be less commonly observed, and this pattern could relate to poor prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Radiological patterns and prognosis in elderly patients with acute Klebsiella pneumoniae pneumonia: A retrospective study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The clinical impact of CRE infections was diverse among patients from different regions. The 30-day all-cause mortality rate was higher in South America (28%) than in China (12-19.7%), the United States (23%), or Taiwan (23.2%) [26][27][28]. Despite there are geographic variations in the prognostic impact of CRE infections among general population, CRE infections lead to more signi cant impact among ICU patients.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and clinical impact of carbapenem-resistant Enterobacterales coinfections among hospitalized patients with Clostridioides difficile infection

Lee

Chiu²,

Lee

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction: The risk factors and clinical impact of carbapenem-resistant Enterobacterales (CRE) coinfection among hospitalized patients with Clostridioides difficile infection (CDI) were analyzed in this study.Materials and methods: A clinical study was performed at the medical wards of Tainan Hospital, Ministry of Health and Welfare in southern Taiwan. Patients with CDI between January 2013 and April 2020 were included.Results: Among 238 patients included for analysis, 22 (9.2%) patients developed CRE coinfections within 14 days before or after the onset of CDI. CDI patients with CRE coinfection had longer hospitalization stays (103.0 ± 97.0 days vs. 42.5 ± 109.6 days, P = 0.01) than those without CRE coinfection. In the multivariate analysis, age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.01-1.10, P = 0.02) was independently associated with CRE coinfection. In contrast, underlying old stroke (OR 0.15, 95% CI 0.03-0.70, P = 0.02) was negatively linked to CRE coinfection.Conclusion: Among patients with CDI, CRE coinfections were associated with prolonged hospitalization for CDI. Age was an independent risk factor for CRE coinfection among patients with CDI.

show abstract

“…The 30-day all-cause mortality rate was higher in South America (28%) than in China (12-19.7%), the United States (23%), or Taiwan (23.2%). [26][27][28] Despite there are geographic variations in the prognostic impact of CRE infections among general population, CRE infections lead to more significant impact among ICU patients. Among patients in the respiratory ICU, CRKP infections resulted in the in-hospital mortality rate up to 42.1%.…”

Section: Discussionmentioning

confidence: 99%

“…25 Moreover, CRE infections have resulted in substantial morbidity and mortality among hospitalized patients worldwide. [26][27][28] In the era of the increasing incidence of CRE infections, the clinical impact of the coexistence of CRE infections among hospitalized patients with CDI was not clear. The objective of this study is to investigate the risk factors and clinical impact of CRE infections among hospitalized patients with CDI.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors and Clinical Impact of Carbapenem-Resistant Enterobacterales Coinfections Among Hospitalized Patients with Clostridioides difficile Infection

Lee¹,

Chiu²,

Lee³

et al. 2022

IDR

View full text Add to dashboard Cite

The risk factors and clinical impact of carbapenem-resistant Enterobacterales (CRE) coinfection among hospitalized patients with Clostridioides difficile infection (CDI) were analyzed in this study. Materials and Methods: A clinical study was performed at the medical wards of Tainan Hospital, Ministry of Health and Welfare in southern Taiwan. Patients with CDI between January 2013 and April 2020 were included. Results: Among 238 patients included for analysis, 22 (9.2%) patients developed CRE coinfections within 14 days before or after the onset of CDI. CDI patients with CRE coinfection had longer hospitalization stays (103.0 ± 97.0 days vs 42.5 ± 109.6 days, P = 0.01) than those without CRE coinfection. In the multivariate analysis, age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.01-1.10, P = 0.02) was independently associated with CRE coinfection. In contrast, underlying old stroke (OR 0.15, 95% CI 0.03-0.70, P = 0.02) was negatively linked to CRE coinfection. Conclusion: Among patients with CDI, CRE coinfections were associated with prolonged hospitalization for CDI. Age was an independent risk factor for CRE coinfection among patients with CDI.

show abstract

Clinical characteristics and outcomes of 56 patients with pneumonia caused by carbapenem-resistant Klebsiella pneumoniae

Cited by 6 publications

References 17 publications

Radiological patterns and prognosis in elderly patients with acute Klebsiella pneumoniae pneumonia: A retrospective study

Radiological patterns and prognosis in elderly patients with acute Klebsiella pneumoniae pneumonia: A retrospective study

Risk factors and clinical impact of carbapenem-resistant Enterobacterales coinfections among hospitalized patients with Clostridioides difficile infection

Risk Factors and Clinical Impact of Carbapenem-Resistant Enterobacterales Coinfections Among Hospitalized Patients with Clostridioides difficile Infection

Contact Info

Product

Resources

About