Clinical characteristics and outcomes in polyarticular septic arthritis

Lieber, Sarah B.; Fowler, Mary Louise; Zhu, Clara; Moore, Andrew; Shmerling, Robert H.; Paz, Ziv

doi:10.1016/j.jbspin.2017.09.001

Cited by 21 publications

(13 citation statements)

References 14 publications

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“…Moreover, it is a rheumatologic emergency, since irreversible joint destruction and consequently loss of function of the joint can occur rapidly [ 24 , 25 , 41 ]. Septic arthritis has a mortality ranging from approximately 10% to, depending on the report, more than 50% in case of polyarticular disease [ 3 , 7 , 41 ]. Persisting joint damage occurs in more than 30% of the patients [ 41 ].…”

Section: Septic Arthritismentioning

confidence: 99%

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Neutrophils: Beneficial and Harmful Cells in Septic Arthritis

Boff

Crijns

Teixeira

et al. 2018

IJMS

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Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and cytokines and is accompanied by an influx of leukocytes. The recruitment of these inflammatory cells depends on gradients of chemoattractants including formylated peptides from the infectious agent or dying cells, host-derived leukotrienes, complement proteins and chemokines. Neutrophils are of major importance and play a dual role in the pathogenesis of septic arthritis. On the one hand, these leukocytes are indispensable in the first-line defense to kill invading pathogens in the early stage of disease. However, on the other hand, neutrophils act as mediators of tissue destruction. Since the elimination of inflammatory neutrophils from the site of inflammation is a prerequisite for resolution of the acute inflammatory response, the prolonged stay of these leukocytes at the inflammatory site can lead to irreversible damage to the infected joint, which is known as an important complication in septic arthritis patients. Thus, timely reduction of the recruitment of inflammatory neutrophils to infected joints may be an efficient therapy to reduce tissue damage in septic arthritis.

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Section: Septic Arthritismentioning

confidence: 99%

“…Bacteria, viruses, fungi and protozoa may invade joints and cause injury. However, Gram-positive bacteria, especially Staphylococcus aureus ( S. aureus ), are the most prevalent microorganisms causing septic arthritis [ 3 ]. In addition, S. aureus is responsible for the most severe cases of septic arthritis.…”

Section: Introductionmentioning

confidence: 99%

Neutrophils: Beneficial and Harmful Cells in Septic Arthritis

Boff

Crijns

Teixeira

et al. 2018

IJMS

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“…From the previous studies, the presence of skin fragility, prior arthritis, diabetes, and poor immune function may increase the risk of septic arthritis occurrence. [5][6][7] The clinical manifestation of our patient was four days history of fluctuating fever and severe progressive pain of the left knee that had begun after three years recurring history of desquamated itchy redness of the entire body skin. The three years clinical history of erythroderma, presented a non intact skin, as a site of entry for skin normal flora into the underlying soft tissue.…”

Section: Discussionmentioning

confidence: 88%

A Case of Deep Vein Thrombosis Associated with Methicillin Sensitive Staphylococcal aureus Genu Septic Arthritis

Effendy¹,

Octora²,

Kusumaningrum³

2020

Infectious Disease Reports

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Septic arthritis caused by bacteria Gram positive Staphylococcus aureus (S. aureus) infection has been widely reported from Europe and the United States. This case presentation reported the first Staphylococcal septic arthritis, preceded by systemic erythroderma skin lesions from aregional hospital in Surabaya, Indonesia. Radiology imaging was used for confirming the defect. Joint fluid aspirate from the affected knee joint lesion was sent for joint fluid analysis and microbiology culture. The analysis showed infiltration of neutrophil inflammatory cells. S. aureus was isolated on culture and demonstrated catalase positive and coagulase positive reactions. Antimicrobial susceptibility testing was performed to determine the appropriate selection of antibiotics. Clindamycin was used for treatment and the complicated occurrence of deep vein thrombosis was treated with anticoagulant. Awareness of this disease and its progression to its complication deep vein thrombosis is required to understand the burden of this disease.

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“…However, nowadays, it represents around 1% of all cases 15 and is 4 times more common in females 16,17 . In people with intravenous drug use and immunosuppressed patients, Pseudomonas is often found 18, and even enterobacteria have been detected as etiological agents of the infection 7,19 . Something to consider is that in approximately half of the cases, the etiological agent might not be identified 20 .…”

Section: Most Common Etiological Agentsmentioning

confidence: 99%

Septic arthritis significance: A path toward awareness

Gonzalez-Chapa¹,

Peña‐Martínez²,

Vílchez-Cavazos³

et al. 2021

RMU

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Septic arthritis is considered the fastest joint destructive disease and a medical emergency. The most common etiological agents are bacteria; Staphylococcus aureus is the main cause of infection. The etiological agent and the host immune response might determine the clinical presentation and the evolution of the disease. Depending on these factors, septic arthritis might be responsible for many complications, including even death. Understanding the immunopathogenesis responsible for the clinical presentation and creating awareness of its importance may help in the medical education, research approaches, and attention of physicians treating this disease. Evidence indicates that bacteria-specific factors such as adhesins, amino acids, toxins, and superantigens are responsible for joint colonization. However, a dual role with a "double-edged sword effect" of the immune system might be responsible for septic arthritis's severe consequences. Due to immune system redundancy, there might not be a specific component responsible for the disastrous complications. However, cells as neutrophils, macrophages, T helper cells, and their cytokines might be playing an important role. Physical complications have been well studied. However, little research has been done regarding the possible psychological effects on these patients due to the morbidities, which clearly affect the outcome of the patients. This report aims to review the available literature on joint infections focusing on the most common etiological agents, the immune response, and the impact this disease can create in the patients.

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Clinical characteristics and outcomes in polyarticular septic arthritis

Cited by 21 publications

References 14 publications

Neutrophils: Beneficial and Harmful Cells in Septic Arthritis

Neutrophils: Beneficial and Harmful Cells in Septic Arthritis

A Case of Deep Vein Thrombosis Associated with Methicillin Sensitive Staphylococcal aureus Genu Septic Arthritis

Septic arthritis significance: A path toward awareness

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