Clinical characteristics and outcome of tumor-associated acute pancreatitis: a single-center cohort study

Xiong, Yangyang; Zhao, Yongqiang; Han, Xiao; Chen, Guorong; Windsor, John A.; Wu, Dong; Qian, Jiaming

doi:10.21037/atm-20-7196

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…In fact, about one percent of AP cases are caused by PDAC [ 9 , 77 ]. The reported prevalence of AP prior to pancreatic cancer ranges between 1.4% and 6%, and most cases of PDAC-induced AP follow a mild disease course [ 75 , 78 , 79 ].…”

Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning

confidence: 99%

“…A Chinese study evaluating clinical predictors of underlying malignancy at the time of AP diagnosis found unexplained dilation of the main pancreatic to be highly suggestive of tumor presence (OR 417.83; 95% CI: 80.40–2171.42). Interestingly, mild AP course was found to be a predictor of PDAC, but in contrast, severe pancreatitis was not associated with new PDAC diagnosis [ 77 , 79 ]. Therefore, presence of PDAC predictors in patients with unexplained AP should elevate clinicians’ index of suspicion to aggressively evaluate and diagnose cancer early utilizing a combination of imaging and endoscopic modalities.…”

Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning

confidence: 99%

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The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review

2021

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with poor prognosis, leading to significant cancer-related mortality and an overall five-year survival rate of about nine percent. Acute and chronic pancreatitis have been associated with PDAC through common risk factors based on multiple epidemiological studies. Acute pancreatitis (AP) might be one of the earliest manifestations of PDAC, but evolving chronic pancreatitis (CP) following recurrent bouts of AP has been proposed as a risk factor for cancer development in the setting of persistent inflammation and ongoing exposure to carcinogens. This review aims to highlight the evidence supporting the relationship between acute and chronic pancreatitis with PDAC.

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Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning

confidence: 99%

Section: Pancreatitis As An Initial Symptom Of Pancreatic Cancermentioning

confidence: 99%

The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review

2021

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“…Furthermore, the time from initial AP to tumor diagnosis seemed to be delayed as Omid et al described [8] and there were more episodes compared to the non-tumor group. The factors that interfere with an early diagnosis and cause recurrent attacks include that a mild course [7], ineffective imaging screening to distinguish between inflammatory edema and tumorous mass [23] and not very valuable information associated with tumor-induced AP owing to low sensitivity. Both age and recurrent attacks were the independent predictors.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristic and pathogenesis of tumor-induced acute pancreatitis: a predictive model

et al. 2022

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Background:The aim of our study was to investigate the clinical characteristics and pathogenesis of tumor-induced acute pancreatitis (AP), and to develop a reliable prediction model of the clinical features to guide the diagnosis and treatment.Methods: Patients with AP between January 2013 and December 2021 were enrolled in the study and were subdivided into the tumor group and the non-tumor group. The tumor group was subdivided into three groups based on the primary sites. Characteristic parameters, laboratory and imaging results were compared between groups. Least absolute shrinkage and selection operator regression model, XGBoost and random forest model were used to select the predictors associated with tumor-induced AP. Logistic regression analysis was used to validate the performance of the selected predictors and a nomogram was established to provide individualized probability of a tumor origin for AP.Results: A total amount of 8970 patients were admitted for AP during the study period, and 8637 AP patients were enrolled in the study. Of these, 100 cases (1.16%) were tumor-induced AP. The tumor group was significantly older than the non-tumor group (t = 6.050, p = 0.000). Mild AP was observed in 90 cases, moderate AP in 9 cases and severe AP in one case. Tumors respectively originated from distal bile duct (14 cases), ampulla (13 cases) and pancreas (73 cases). The median time from initial AP to tumor diagnosis was 8.57 weeks and the median number of episode was 2 in the tumor group, which significantly surpassed the non-tumor group (p = 0.000). Age, white blood cell count, percentage of neutrophils, pancreatic or bile duct dilation and recurrent attacks were selected independent predictors for tumor origin. A nomogram model based on these factors was established. Conclusion:For patients with agnogenic AP, elderly man, recurrent attacks, pancreatic or bile duct dilatation and continuous no significant increase of inflammatory markers prompt to further screening of pancreatic biliary and ampulla.

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“…Most cases of AP caused by PDAC have a mild clinical course, which may result in limited diagnostics towards a potential malignancy. Mild AP turned out to be a predictor of PDAC, while severe AP was not associated with PDAC [67,68]. Therefore, in patients with mild AP without an identifiable cause, a possible underlying PDAC may be suspected.…”

Section: Acute Pancreatitismentioning

confidence: 96%

Gaps and Opportunities in the Diagnosis and Treatment of Pancreatic Cancer

Caban,

Małecka-Wojciesko

2023

Cancers

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Pancreatic cancer is one of the leading causes off cancer-related deaths globally. In Europe, this type of cancer has the lowest survival rate of all cancers. A majority of patients have unresectable or even metastatic disease. In addition, actual therapeutic options are not curative, and surgical treatment is associated with high post-operative morbidity and a lack of uniform translation of surgical success into long-term survival. Moreover, there is no screening for the general population which is recommended, and the overall poor prognosis in pancreatic cancer is related to late clinical detection. Therefore, early diagnosis and early treatment of pancreatic cancer are particularly critical. In this review, we summarize the most significant gaps and opportunities in the diagnosis and treatment of pancreatic cancer to emphasize need for improvement of early detection and the therapeutic efficacy of the available treatment for this cancer. Novel, inclusive, and intentional research is needed to produce improvements in pancreatic cancer in mm the world.

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Clinical characteristics and outcome of tumor-associated acute pancreatitis: a single-center cohort study

Cited by 6 publications

References 23 publications

The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review

The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review

Clinical characteristic and pathogenesis of tumor-induced acute pancreatitis: a predictive model

Gaps and Opportunities in the Diagnosis and Treatment of Pancreatic Cancer

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