Clinical Characteristics and Outcome of Familial Nonmedullary Thyroid Cancer: A Retrospective Controlled Study

Abstract

Our results suggest that FNMTC is not more aggressive than sporadic thyroid cancer within our studied population. After a similar therapeutic strategy, FNMTC and sporadic cases had comparable prognosis, including in families with three or more affected members.

ENDOCRINE TUMOURS: Familial nonmedullary thyroid carcinoma is a more aggressive disease: a systematic review and meta-analysis

“…Of these, 1165 studies were excluded after the first screening based on titles or abstracts. After further reviewing the full text of the remaining 53 articles, a total of 12 studies finally satisfied the eligibility criteria (11,12,13,14,15,16,18,19,20,21,33,34).…”

“…All were retrospective studies, including eight cohort studies (11,13,14,15,16,18,20,34) and four case-control studies (12,19,21,33), and all of them were hospital-based studies. The included studies were published between 2000 and 2014, and the number of patients ranged from 136 to 6015, for a total of 12 741 subjects across studies, including 1087 cases of FNMTC.…”

“…The included studies were published between 2000 and 2014, and the number of patients ranged from 136 to 6015, for a total of 12 741 subjects across studies, including 1087 cases of FNMTC. Of the 12 included studies, five studies were conducted in Asia (11,14,15,18,21), four in North America (13,16,19,20), two in Europe (33,34), and the remaining one included patients from Japan and USA (12). FNMTC was defined as patients with two or more first-degree relatives with NMTC in eight studies, while it was defined as occurring when at least one first-degree relative was affected with NMTC in the other four studies (13,14,15,18).…”

“…FNMTC was defined as patients with two or more first-degree relatives with NMTC in eight studies, while it was defined as occurring when at least one first-degree relative was affected with NMTC in the other four studies (13,14,15,18). Despite the variations in the diagnosis criteria of recurrence observed in the included studies, most of the authors defined recurrence based on a variable combination of results including clinical, radiographic, and nuclear medicine imaging studies; serum Tg level; and hisopathologic findings (11,12,13,15,18,19,21,34). However, there were three articles which did not provide the information about definition of recurrence (14,16,33).…”

“…Therefore, some of them recommended more aggressive initial treatment for patients with FNMTC, including total thyroidectomy (TT) and concomitant prophylactic central compartment node dissection (14,17). However, certain other studies did not confirm the difference in biological behaviors between FNMTC and SNMTC (18,19,20,21). In addition, results from several published reviews are conflicting, which have only listed major results of available studies and failed to draw conclusions based on quantitative statistical methods (9,22,23).…”