Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry

Mayosi, Bongani M.; Wiysonge, Charles Shey; Ntsekhe, Mpiko; Volmink, Jimmy; Gumedze, Freedom; Maartens, Gary; Aje, Akinyemi; Thomas, Baby; Thomas, Kandathil; Awotedu, A A; Thembela, Bongani; Mntla, Pindile; Maritz, Frans; Blackett, Kathleen Ngu; Nkouonlack, Duquesne C.; Burch, Vanessa; Rebe, Kevin; Parish, Andy; Sliwa, Karen; Vezi, Brian; Alam, Nowshad; Brown, Basil; Gould, Trevor; Visser, Tim; Shey, Muki; Magula, Nombulelo; Commerford, Patrick

doi:10.1186/1471-2334-6-2

Cited by 110 publications

(111 citation statements)

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“…23 There is a clear need, therefore, to develop African-specific prevention programs that optimize the detection and management of hypertension in addition to targeting those most at risk of developing peripartum cardiomyopathy 19 and HIVrelated cardiomyopathy. 18 These data also reaffirm that valvular disorders play a pivotal role in the development of HF in Africa, with 8% of de novo HF cases attributable to primary valve disease (mostly chronic rheumatic heart disease) and Ϸ25% of most forms of HF having concurrent valve dysfunction. Significantly, not a single case of acute rheumatic fever, a previously common diagnosis in the region, 24 was documented, most probably reflecting less overcrowding, better sanitation, and access to antibiotic therapy in children and young adults.…”

Section: Discussionsupporting

confidence: 49%

Predominance of Heart Failure in the Heart of Soweto Study Cohort

et al. 2008

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Section: Discussionsupporting

confidence: 49%

Predominance of Heart Failure in the Heart of Soweto Study Cohort

et al. 2008

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“…Z kolei gruźlica jest przyczyną gromadzenia się znacznych ilości płynu w osierdziu u > 90% pacjentów zakażonych HIV i u 50-70% osób niezakażonych HIV w krajach rozwijających się, gdzie gruźlica jest zakażeniem endemicznym [77]. Choroba może wystąpić w każdym wieku, częściej dotyczy męż-czyzn [140]. Często obserwowanym objawem jest przewlekły ucisk na serce przypominający przewlekłą niewydolność serca [79,93].…”

Section: Gruźlicze Zapalenie Osierdziaunclassified

2015 ESC Guidelines for the diagnosis and management of pericardial diseases

Adler

Charron²,

Imazio³

et al. 2015

Kardiol Pol

193

293

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“…30 In Africa, the majority of pericardial disease in HIV infected patients is caused by TB. 31,32 The incidence of pericarditis has also been decreasing since the introduction of HAART.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Abnormalities in Patients With Hiv Infection: A Bolt in Blue

Arya¹,

Deshmukh²,

Mundada³

2015

jemds

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One of the consistent findings among various studies on HIV has been simultaneous multiorgan dysfunction. Cardiovascular disorders are now most common cause of mortality worldwide. With more effective and widespread treatment of HIV in resourcerich settings, morbidity and mortality from non-AIDS-related events have surpassed those from AIDS-related events with cardiovascular diseases emerging as an important cause of death in HIV-infected patients relative to the decreasing incidence of opportunistic disease. Various studies have reported a 1.5-fold increase in the rate of cardiovascular events in HIV-infected individuals compared to control populations. MATERIAL AND METHODSThe aim of the study was to the find the prevalence and types of different cardiovascular abnormalities in HIV positive patients and assess their association with CD4 counts. Consecutive 82 patients, HIV positive patients fulfilling the inclusion criteria and giving informed consent were included in the study. All patients were subjected to history taking and a detailed physical examination. Blood counts, renal function tests, lipid profile and CD4 counts were estimated and patients were subjected to 12-lead ECG, chest X-ray and 2D/Colour Doppler Echocardiogram. RESULTSOf the 82 patients studied 47.46% had evidence of cardiovascular involvement, out of which 12% had clinical features of heart failure while electrocardiographic changes were seen in 35% of patients in the form of sinus tachycardia (27%), QTc prolongation (10%) and left sided chamber enlargements (6%). Echocardiographic abnormalities were noted in 39 patients (47.56%) including fractional shortening associated with systolic dysfunction (26.8%). The mean CD4 count in patients with echocardiographic abnormalities was found to be 58.87±29.80, whereas in patients without echocardiographic abnormalities it was 136.53±38.80 (p<0.0001). CONCLUSIONHigh frequencies of cardiac abnormalities, both symptomatic and asymptomatic were detected in the HIV/AIDS patients in our study. Furthermore, the study concluded that a careful initial and periodic cardiac evaluation to detect early involvement of the cardiovascular system in the HIV disease is recommended. Since the HIV-infected population is relatively young and actual cardiovascular events are infrequent, more long terms studies are needed.

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Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry

Abstract: Background: The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical

Cited by 110 publications

References 19 publications

Predominance of Heart Failure in the Heart of Soweto Study Cohort

Predominance of Heart Failure in the Heart of Soweto Study Cohort

2015 ESC Guidelines for the diagnosis and management of pericardial diseases

Cardiovascular Abnormalities in Patients With Hiv Infection: A Bolt in Blue

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