Clinical characteristics and in‐hospital mortality of patients with COVID‐19 in Chile: A prospective cohort study

Abstract

Aims of this study To describe the Latin American population affected by COVID‐19, and to determine relevant risk factors for in‐hospital mortality. Methods We prospectively registered relevant clinical, laboratory, and radiological data of adult patients with COVID‐19, admitted within the first 100 days of the pandemic from a single teaching hospital in Santiago, Chile. The primary outcome was in‐hospital mortality. Secondary outcomes included the need for respiratory support and pharmacological treatment, among others. We combined the chronic disease burden and the severity of illness at admission with predefined clinically relevant risk factors. Cox regression models were used to identify risk factors for in‐hospital mortality. Results We enrolled 395 adult patients, their median age was 61 years; 62.8% of patients were male and 40.1% had a Modified Charlson Comorbidity Index (MCCI) ≥5. Their median Sequential Organ Failure Assessment (SOFA) score was 3; 34.9% used a high‐flow nasal cannula and 17.5% required invasive mechanical ventilation. The in‐hospital mortality rate was 14.7%. In the multivariate analysis, were significant risk factors for in‐hospital mortality: MCCI ≥5 (HR 4.39, P < .001), PaO 2 /FiO 2 ratio ≤200 (HR 1.92, P = .037), and advanced chronic respiratory disease ( HR 3.24, P = .001); pre‐specified combinations of these risk factors in four categories was associated with the outcome in a graded manner. Conclusions and clinical implications The relationship between multiple prognostic factors has been scarcely reported in Latin American patients with COVID‐19. By combining different clinically relevant risk factors, we can identify COVID‐19 patients with high‐, medium‐ and low‐risk of in‐hospital mortality.

Charlson comorbidity index, neutrophil-to-lymphocyte ratio and undertreatment with renin-angiotensin-aldosterone system inhibitors predict in-hospital mortality of hospitalized COVID-19 patients during the omicron dominant period

“…The overall in-hospital mortality rate detected in our series of COVID-19 patients was higher than that observed in previous studies which included younger patients ( 16 , 17 ) and similar to that observed in other studies which enrolled geriatric patients with several comorbid conditions ( 18 , 19 ).…”

COVID-19 Vaccination and Mortality Reduction: A Prospective Cohort Study in Venezuela

“…However, no signi cant differences were observed upon calculation of the Charlson Comorbidity Index for each group. The most prevalent symptoms and signs, including dyspnea, fever, dry cough, tachypnea, and decreased oxygen saturation, were consistent with previous studies [39][40][41][42][43][44][45][46][47][48][49][50]. Unvaccinated patients had a higher prevalence of dyspnea, increased respiratory rate, and lower oxygen saturation values, corroborating ndings from similar studies [51][52][53][54][55].…”

Spatial Variability of COVID-19 Hospitalization in the Silesian Region, Poland

“…Additionally, in the second year of observation, the percent of in-hospital mortality remained at a high level, close to 20% which was typical for the colder months of the previous year. It was confirmed that the in-hospital mortality rate observed in Silesian voivodeship was higher than the values reported by other authors [ 19 , 20 ]. It is worth mentioning that the development of population immunity is a long-term process.…”