Clinical Characteristics, Activity Levels and Mental Health Problems in Children with Long Coronavirus Disease: A Survey of 510 Children

Buonsenso, Danilo; Pujol, Ferran Espuny; Munblit, Daniel; Pata, Davide; Mcfarland, Sammie; Simpson, Frances

doi:10.2217/fmb-2021-0285

Cited by 74 publications

(64 citation statements)

References 21 publications

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“…The effect of COVID infection on language problems within neurocognitive functions in children and adolescents has been less studied. Parents of children and adolescents with SARS-CoV-2 infection reported different language/speech dysfunctions including word repetition (12.1%) (32), trouble finding the right words (32), speech disturbances (1.3%) (27), and trouble forming words (0.4%) (37). In line with these findings, in a meta-analysis study, speech disturbances were declared as 0.4% in children and adolescents with SARS-CoV-2 infection (15).…”

Section: Language Functionsmentioning

confidence: 64%

Persistent Neurocognitive Problems Related to COVID-19 in Children and Adolescents

Mutlu¹,

Taşpolat²

2022

csmedj

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused persistent multisystemic symptoms. Data on the long-term effects of coronavirus disease-2019 (COVID-19) in children and adolescents are scarce. Persistent neurocognitive symptoms are important for the functionality of children in daily life. This review assessed the literature regarding the frequency, pathology, risk factors, and prognosis of the long-term neurocognitive effects of COVID-19 in the pediatric population. This review demonstrated that children and adolescents had various persistent neurocognitive problems related to COVID-19. The heterogeneity of studies prevents from drawing firm conclusions, as there were differences between study populations and designs in terms of disease severity and time of assessment. Because the pandemic is a recent event, long-term follow-ups to establish how long cognitive impairment persists after COVID-19 recovery are still impossible.

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Section: Language Functionsmentioning

confidence: 64%

Persistent Neurocognitive Problems Related to COVID-19 in Children and Adolescents

Mutlu¹,

Taşpolat²

2022

csmedj

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“… 18 Therefore, it is plausible to assume that symptoms compatible with long‐COVID may persist for an extended period of time in some patients. 19 , 20 Any persistent medical problems in children and adolescents, who are suffering from long‐COVID, should be identified after the acute phase of the infection and adequately managed to assure complete resolution. 19 …”

Section: Discussionmentioning

confidence: 99%

‘Long COVID’: Symptom persistence in children hospitalised for COVID‐19

Asadi‐Pooya

Nemati

2022

J Paediatrics Child Health

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AimWe aimed to describe the long‐term outcome with respect to symptom persistence amongst children hospitalised for COVID‐19.MethodsThis was a follow‐up study of 58 children and adolescents hospitalised with COVID‐19. For all patients, the data were collected in a phone call to the family in December 2021 (9 months after the initial study and more than 13 months after their admission to hospital). We inquired about their current health status and obtained information, if the responding parent consented orally to participate and answer the questions.ResultsFifty‐one children and adolescents were studied. Only five patients (10%) had persistent symptoms compatible with long‐COVID; the reported symptoms include fatigue in four (8%), weakness in three (6%), exercise intolerance in two (4%) and shortness of breath in two (4%) patients. Four patients (7.8%), who did not have any symptoms of long‐COVID in phase 1 of the study, reported new‐onset symptoms or complaints that are potentially compatible with the diagnosis of long‐COVID (weakness, myalgia, excess sputum, cough, fatigue) in the current phase.ConclusionsSymptom persistence of long‐COVID is infrequent amongst children hospitalised for COVID‐19. Most of the symptoms of long‐COVID will resolve with the passage of time and the residual symptoms are often mild and tolerable. The scientific community should carefully and clearly define long‐COVID and its natural course in order to facilitate and harmonise future studies.

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“…Despite the subjective nature of the symptoms frequently described in children with PCS, Buonsenso et al (35) support that mental, muscoskeletal, and cardiovascular manifestations are considered the most PCS characteristic conditions of PCS in children. A recent meta-analysis showed that the incidence of PCS can approximately reach 30% of hospitalized COVID-19 children (36).…”

Section: Incidence Of Pcs In Childrenmentioning

confidence: 99%

Post‑COVID‑19 syndrome in children (Review)

Filippatos

Tatsi²,

Michos

2022

Exp Ther Med

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The persistence of symptoms for a long time after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is now familiar as post-COVID syndrome (PCS). To the best of our knowledge, the risk of long-term clinical outcomes in children after SARS-CoV-2 infection is still unclear. Unlike in adults, current evidence suggests a lower prevalence of persistent symptoms in children. However, since several studies are characterized by great heterogeneity, it is difficult to accurately estimate the exact incidence of PCS in children. The presence and course of recovery depend on risk factors that are more common in adults than children. Proposed pathophysiological mechanisms in PCS in children include age-dependent immune responses, angiotensin-converting enzyme 2 expression, blood-brain barrier development or social issues affecting children behavior, such as school closure and social isolation. However, further longitudinal studies are required for unanswered issues to be clarified. The aim of the present review is to describe the long-term symptoms per biological system in children, potential risk factors and the role of the immune system in the presence of PCS.

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Clinical Characteristics, Activity Levels and Mental Health Problems in Children with Long Coronavirus Disease: A Survey of 510 Children

Cited by 74 publications

References 21 publications

Persistent Neurocognitive Problems Related to COVID-19 in Children and Adolescents

Persistent Neurocognitive Problems Related to COVID-19 in Children and Adolescents

‘Long COVID’: Symptom persistence in children hospitalised for COVID‐19

Post‑COVID‑19 syndrome in children (Review)

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